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|Conjugated Estrogens Tablets

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Conjugated Estrogens

Generic Name: Conjugated Estrogens Tablets (CON-ju-gate-ed ESS-tro-jenz)
Brand Name: Premarin

Conjugated Estrogens increases the chances of getting cancer of the uterus. Report any unusual vaginal bleeding right away while using Conjugated Estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider should check any unusual vaginal bleeding to find out the cause.

Do not use Conjugated Estrogens with or without progestins (eg, medroxyprogesterone) to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins, may increase your risk of dementia, based on a study of women 65 years of age or older. You and your health care provider should talk regularly about whether you still need treatment with Conjugated Estrogens.

Conjugated Estrogens is used for:

Treating symptoms of advanced breast cancer in selected men and women; treating or preventing a variety of symptoms due to menopause (hot flashes, vaginal itching, burning, dryness); preventing osteoporosis (brittle bones) after menopause; replacing estrogen after failure of the ovaries; and treating advanced prostate cancer in men. Conjugated Estrogens may be used for certain conditions, as determined by your doctor, which may not be listed in the professional package insert. If you have questions about how Conjugated Estrogens is being used, contact your doctor.

Conjugated Estrogens is a mixture of female estrogen hormones. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.It works for advanced prostate cancer by antagonizing male hormones.

Do NOT use Conjugated Estrogens if:

you are allergic to any ingredient in Conjugated Estrogens
you are pregnant or suspect you may be pregnant
you have known, suspected, or a history of breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
you have abnormal vaginal bleeding of unknown cause
you have impaired liver function or liver disease, or the blood disease porphyria
you have recently (within the last year) had a stroke or heart attack
you have blood clots or circulation disorders

Contact your doctor or health care provider right away if any of these apply to you.

Before using Conjugated Estrogens:

Some medical conditions may interact with Conjugated Estrogens. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines or other substances
if you have an abnormal mammogram
if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood
if you use tobacco, you are going to have surgery, or you will be on bed rest
if you have a family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer

Some MEDICINES MAY INTERACT with Conjugated Estrogens. Tell your health care provider if you are taking any other medicines, especially any of the following:

Hydantoins (eg, phenytoin) and rifampin because the effectiveness of this medication may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Conjugated Estrogens may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Conjugated Estrogens:

Use Conjugated Estrogens as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Conjugated Estrogens with food or immediately after a meal to prevent stomach upset.
Conjugated Estrogens comes with an additional patient leaflet. Read it carefully.
Take Conjugated Estrogens at the same time each day.
Discuss with your doctor stopping Conjugated Estrogens 4 to 6 weeks before surgery.
If you miss a dose of Conjugated Estrogens, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Conjugated Estrogens.

Important safety information:

Conjugated Estrogens may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Conjugated Estrogens. Using Conjugated Estrogens alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Smoking while taking Conjugated Estrogens may increase your risk of blood clots (especially in women older than 35 years of age).
Before using Conjugated Estrogens, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
You should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately.
Your doctor should reevaluate you every 3 to 6 months to determine whether or not you need to continue taking Conjugated Estrogens.
If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
Non-drug therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor of pharmacist for more details.
Diabetes patients - Conjugated Estrogens may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
Conjugated Estrogens may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
If you wear contact lenses and you develop problems with them, contact your doctor.
If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Conjugated Estrogens.
Conjugated Estrogens may affect certain lab test results. Make sure laboratory personnel and your doctors know you use Conjugated Estrogens.
LAB TESTS, including a lipid profile, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
Use Conjugated Estrogens with caution in CHILDREN. Their growth pattern should be monitored as Conjugated Estrogens might stunt their growth.
PREGNANCY and LACTATION: Do not use Conjugated Estrogens if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Conjugated Estrogens is excreted in breast milk. If you are or will be breast-feeding while you are taking Conjugated Estrogens, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Conjugated Estrogens:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; dizziness; fainting; mental/mood changes; pain or tenderness in the upper abdomen; pain in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include excessive vaginal bleeding 2 to 7 days following overdose, nausea and vomiting.

Proper storage of Conjugated Estrogens:

Store Conjugated Estrogens at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Do not store in the bathroom. Keep Conjugated Estrogens out of the reach of children and away from pets.

General information:

If you have any questions about Conjugated Estrogens, please talk with your doctor, pharmacist, or other health care provider.
Conjugated Estrogens is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Conjugated Estrogens. Additionally, your doctor may have prescribed Conjugated Estrogens for a use not mentioned above. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

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