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|Chromium Chromium

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Chromium

Pronouncation: (KROE-mee-uhm)
Class: Trace Metal

Trade Names:
Chromic Chloride
- Injection 4 mcg/mL (as 20.5 mcg chromic chloride hexahydrate)
- Injection 20 mcg/mL (as 102.5 mcg chromic chloride hexahydrate)

Trade Names:
Chromium Chloride
- Injection 4 mcg/mL (as 20.5 mcg chromic chloride hexahydrate)

Trade Names:
Chroma-Pak
- Injection 4 mcg/mL (as 20.5 mcg chromic chloride hexahydrate)
- Injection 20 mcg/mL (as 102.5 mcg chromic chloride hexahydrate)

Mechanism of Action

Pharmacology

Helps maintain normal glucose metabolism and peripheral nerve function.

Pharmacokinetics

Absorption

Typical blood levels range from 1 to 5 mcg/L.

Elimination

Primarily via the kidney.

Indications and Usage

Use as a supplement to IV solutions given for total parenteral nutrition (TPN) to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Contraindications

Direct IM or IV injection.

Dosage and Administration

Trace Metal for TPN
Adults

TPN Additive 10 to 15 mcg/day. Metabolically stable adults with intestinal fluid loss may require 20 mcg/day.

Children

TPN Additive 0.14 to 0.20 mcg/kg/day.

General Advice

For admixture in TPN solution only. Not for intradermal, SC, IM, or direct IV administration.
Do not administer if particulate matter, cloudiness, or discoloration are noted.
Discard any unused solution in the single-dose vial. Do not save for future use.

Storage/Stability

Store vials at controlled room temperature (59° to 86°F).

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

None known.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established (see Route/Dosage).

Renal Function

Dosage may need to be adjusted or omitted.

General

Use only in conjunction with a pharmacy-directed admixture program using aseptic technique in a laminar flow environment.

Overdosage

Symptoms

Nausea, vomiting, GI ulcers, renal and hepatic damage, convulsions, coma.

Patient Information

Explain name, action, and potential side effects of drug.
Advise patient, family, or caregiver that medication will be added to TPN solution.
Advise patient to report pain, redness, warmth, or swelling of TPN access site.
Advise patient that follow-up visits and lab tests will be required to monitor therapy and to keep appointments.

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