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|Caspofungin Acetate |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Caspofungin AcetatePronouncation: (KASS-poe-FUN-jin ASS-eh-tate)Class: Echinocandins, Antifungal agent Trade Names: Mechanism of ActionPharmacologyInhibits synthesis of β-(1,3)-D-glucan, an integral component of fungal cell wall. PharmacokineticsDistributionAbout 97% protein bound (albumin). MetabolismSlowly metabolized by hydrolysis and N-acetylation and undergoes spontaneous chemical degradation. EliminationThe t ½ is 9 to 11 hr (beta phase) and 40 to 50 hr (gamma phase). 35% is excreted in feces and 41% in urine (about 1.4% as unchanged drug). Renal Cl is about 0.15 mL/min. Total Cl is 12 mL/min. Not dialyzable. Special PopulationsRenal Function ImpairmentAUC is increased 30% to 49% in those with Ccr up to 49 mL/min. Hepatic Function ImpairmentMild (Child-Pugh score 5 to 6) AUC is increased about 55%. Moderate (Child-Pugh score 7 to 9)AUC is increased 76%. ElderlyAUC is increased about 28%. No dosage adjustment is needed. Indications and UsageTreatment of invasive aspergillosis in patients refractory to or intolerant of other antifungal therapies; empirical treatment for presumed fungal infections in febrile, neutropenic patients; treatment of esophageal candidiasis; treatment of Candidemia and the following Candida infections: intra-abdominal abscesses, peritonitis, and pleural space infections. ContraindicationsStandard considerations. Dosage and AdministrationInvasive Aspergillosis, Candidemia and other Candida Infections, Empirical Treatment of Fungal InfectionsAdults IV Loading dose: 70 mg given by slow infusion of about 1 hr on day 1. Maintenance dose: 50 mg daily by slow infusion of about 1 hr thereafter. Esophageal CandidiasisAdults IV 50 mg daily by slow infusion of about 1 hr. Hepatic Function ImpairmentMild hepatic insufficiency (Child-Pugh score 7 to 9), reduce maintenance dose to 35 mg daily. General Advice
Storage/StabilityStore unopened vials in refrigerator (36° to 46°F). Reconstituted caspofungin solution may be stored at temperature less than 77°F for 1 hr prior to preparing diluted IV infusion solution. IV infusion solution in IV bag or bottle can be stored at temperatures less than 77°F for 24 hr or in refrigerator (36° to 46°F) for 48 hr. Drug InteractionsCyclosporineAvoid concurrent use if possible because caspofungin levels may be elevated, increasing the risk of side effects. Inducers or mixed inducers/inhibitors of drug clearance (eg, carbamazepine, dexamethasone, efavirenz, nelfinavir, nevirapine, phenytoin, rifampin)Caspofungin blood levels may be decreased, reducing the efficacy. Coadministration may require an increase in dose to 70 mg of caspofungin daily. TacrolimusTacrolimus blood levels may be decreased, reducing the efficacy. IncompatibilityDo not mix or co-infuse with other medications. Do not use diluents containing dextrose. Caspofungin is not stable in diluents containing dextrose. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularPhlebitis, thrombophlebitis (16%); hypertension, tachycardia (2%); hypotension (1%); swelling and peripheral edema (postmarketing). CNSHeadache (11%); paresthesia (3%); dizziness, tremor (2%); insomnia (1%). DermatologicRash (6%); flushing, induration, perspiration/diaphoresis, pruritus, sweating (3%); erythema (2%). GINausea (6%); abdominal pain, diarrhea, vomiting (4%); anorexia (1%). GenitourinaryRenal insufficiency (1%). Hematologic-LymphaticDecreased Hgb (12%); decreased Hct (11%); decreased WBC (6%); anemia (4%); decreased neutrophils, decreased platelets, increased eosinophils (3%); increased lymphocytes, increased PT (2%). HepaticJaundice (1%); hepatic dysfunction (postmarketing). Lab TestsDecreased serum potassium, increased alkaline phosphatase (11%); increased alanine aminotransferase and aspartate aminotransferase (10%); decreased serum albumin (9%); increased urine WBC (8%); increased urine protein (5%); increased direct serum bilirubin; increased serum creatinine, increased urine RBC (4%); decreased serum protein, increased total serum bilirubin (3%); decreased serum calcium, hypomagnesemia, increased blood urea, serum sodium decreased (2%); increased serum potassium, decreased serum bicarbonate, serum uric acid increased, urine pH increased (1%). LocalInfused vein complication (12%). Metabolic-NutritionalHypokalemia (4%); edema, facial (3%); hypercalcemia (postmarketing). MusculoskeletalMyalgia (3%); back pain, musculoskeletal pain (1%). RespiratoryDyspnea (2%); tachypnea (1%). MiscellaneousFever (26%); chills (14%); pain (5%); flu-like symptoms (3%). Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. Patient Information
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