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VITAMIN D AND RELATED COMPOUNDS (Systemic)
Some commonly used brand names are:
In the U.S.—
Vitamins ((VYE-ta-mins)) are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.
Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.
Ergocalciferol is the form of vitamin D used in vitamin supplements.
Some conditions may increase your need for vitamin D. These include:
In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.
Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.
Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.
Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of ergocalciferol and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor"s prescription. Other strengths of ergocalciferol are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects .
Vitamin D and related compounds are available in the following dosage forms:
Importance of DietFor good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement.
Vitamin D is found naturally only in fish and fish-liver oils. However, it is also found in milk (vitamin D-fortified). Cooking does not affect the vitamin D in foods. Vitamin D is sometimes called the ""sunshine vitamin"" since it is made in your skin when you are exposed to sunlight. If you eat a balanced diet and get outside in the sunshine at least 1.5 to 2 hours a week, you should be getting all the vitamin D you need.
Vitamins alone will not take the place of a good diet and will not provide energy. Your body also needs other substances found in food such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, fat is needed so that vitamin D can be absorbed into the body.
The daily amount of vitamin D needed is defined in several different ways.
In the past, the RDA and RNI for vitamin D have been expressed in Units (U). This term has been replaced by micrograms (mcg) of vitamin D.
Normal daily recommended intakes in mcg and Units are generally defined as follows:
Before Using This Dietary Supplement
If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For vitamin D and related compounds, the following should be considered:
Allergies—Tell your health care professional if you have ever had any unusual or allergic reaction to alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol, ergocalciferol, or paricalcitol. Also, tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—It is especially important that you are receiving enough vitamin D when you become pregnant and that you continue to receive the right amounts of vitamins throughout your pregnancy. The healthy growth and development of the fetus depend on a steady supply of nutrients from the mother.
You may need vitamin D supplements if you are a strict vegetarian (vegan-vegetarian) and/or have little exposure to sunlight and do not drink vitamin D-fortified milk.
Taking too much alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol can also be harmful to the fetus. Taking more than your health care professional has recommended can cause your baby to be more sensitive than usual to its effects, can cause problems with a gland called the parathyroid, and can cause a defect in the baby"s heart.
Doxercalciferol or paricalcitol have not been studied in pregnant women. However, studies in animals have shown that paricalcitol causes problems in newborns. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.
Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.
It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.
Children—Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.
Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.
Older adults—Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.
Medicines or other dietary supplements—Although certain medicines or dietary supplements should not be used together at all, in other cases they may be used together even if an interaction might occur. In these cases, your health care professional may want to change the dose, or other precautions may be necessary. When you are taking vitamin D and related compounds, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of vitamin D and related compounds. Make sure you tell your health care professional if you have any other medical problems, especially:
Proper Use of This Dietary Supplement
For use as a dietary supplement :
If you have any questions about this, check with your health care professional.
For individuals taking the oral liquid form of this dietary supplement:
While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.
Dosing—The dose of these vitamin D and related compounds will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your health care professional tells you to do so.
The number of milliliters (mL) of solution that you take, or the number of capsules or tablets you take, depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking the combination medicine .
Storage—To store this dietary supplement:
Precautions While Using This Dietary Supplement
For individuals taking vitamin D without a prescription :
If you are taking this medicine for a reason other than as a dietary supplement, your doctor should check your progress at regular visits to make sure that it does not cause unwanted effects.
Do not take any nonprescription (over-the-counter [OTC]) medicine or dietary supplement that contains calcium, phosphorus, or vitamin D while you are taking any of these dietary supplements unless you have been told to do so by your health care professional. The extra calcium, phosphorus, or vitamin D may increase the chance of side effects.
Do not take antacids or other medicines containing magnesium while you are taking any of these medicines. Taking these medicines together may cause unwanted effects .
Side Effects of This Dietary Supplement
Along with its needed effects, a dietary supplement may cause some unwanted effects. Alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, and ergocalciferol do not usually cause any side effects when taken as directed. However, taking large amounts over a period of time may cause some unwanted effects that can be serious .
Check with your doctor immediately if any of the following effects occur:
Late symptoms of severe overdose
High blood pressure; high fever; irregular heartbeat; stomach pain (severe)
Check with your health care professional as soon as possible if any of the following effects occur:
Early symptoms of overdose
Bone pain; constipation (especially in children or adolescents); diarrhea; drowsiness; dryness of mouth; headache (continuing); increased thirst; increase in frequency of urination, especially at night, or in amount of urine; irregular heartbeat; itching skin; loss of appetite; metallic taste; muscle pain; nausea or vomiting (especially in children or adolescents); unusual tiredness or weakness
Late symptoms of overdose
Bone pain; calcium deposits (hard lumps) in tissues outside of the bone; cloudy urine; drowsiness; increased sensitivity of eyes to light or irritation of eyes; itching of skin; loss of appetite; loss of sex drive; mood or mental changes; muscle pain; nausea or vomiting; protein in the urine; redness or discharge of the eye, eyelid, or lining of the eyelid; runny nose; weight loss
Other side effects not listed above may also occur in some individuals. If you notice any other effects, check with your health care professional.
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