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Buprenex, |buprenorphine injection Buprenorphine

buprenorphine

Generic Name: buprenorphine (injection) (byoo pre NOR feen)
Brand Names: Buprenex

What is buprenorphine injection?

Buprenorphine is an opioid (narcotic) medication that is similar to morphine, codeine, and heroin..

Buprenorphine injection is used to treat moderate to severe pain.

Buprenorphine injection may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about buprenorphine injection?

Like other narcotic medicines, buprenorphine injection can slow your breathing, even after the pain-relieving effects wear off. Death may occur if breathing becomes too weak.

Using buprenorphine injection together with other drugs that cause drowsiness can slow the functions of your breathing and central nervous system to dangerous levels. These effects could result in a fatal overdose.

What should I discuss with my healthcare provider before receiving buprenorphine injection?

Before using buprenorphine, tell your doctor if you are allergic to any drugs, or if you have:

• asthma, COPD, sleep apnea, or other breathing disorders;

• liver or kidney disease;

• mental illness or a history of suicide attempt;

• a history of alcoholism or IV drug use; or

• a history of seizures, head injury, or brain tumor.

If you have any of these conditions, you may not be able to receive buprenorphine injection, or you may need a dosage adjustment or special tests during treatment.

How is buprenorphine injection given?

Buprenorphine injection is given through a needle placed into a muscle. You will most likely receive this injection in a clinic or hospital setting. The medicine must be given slowly and can take up to 2 minutes to inject.

To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

What happens if I miss a dose?

Since buprenorphine injection is usually given by a healthcare provider, it is unlikely that you will miss a dose.

What happens if I overdose?

Symptoms of a buprenorphine overdose may include slowed breathing, extreme weakness, cold or clammy skin, small pupils, fainting, and coma.

What should I avoid while receiving buprenorphine injection?

Using buprenorphine injection together with other drugs that cause drowsiness can slow the functions of your breathing and central nervous system to dangerous levels. These effects could result in a fatal overdose.

Buprenorphine injection side effects

Like other narcotic medicines, buprenorphine injection can slow your breathing. Death may occur if breathing becomes too weak.

• slow or shallow breathing;

• feeling light-headed, fainting;

• confusion, unusual thoughts or behavior; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may be more likely to occur, such as:

• headache;

• stomach pain, nausea, vomiting, constipation;

• warmth or tingly feeling;

• increased sweating;

• weakness;

• back pain;

• anxiety, depression;

• sleep problems (insomnia); or

• runny nose.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect buprenorphine injection?

Before receiving buprenorphine injection, tell your doctor if you use any of the following drugs:

• an antifungal antibiotic such as fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), or voriconazole (Vfend);

• an antibacterial antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Ery-Tab, Erythrocin), or telithromycin (Ketek);

• HIV medication such as nevirapine (Viramune), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Invirase), or nelfinavir (Viracept);

• rifampin (Rifadin, Rifater, Rifamate, Rimactane);

• a sedative such as diazepam (Valium), midazolam (Versed), alprazolam (Xanax) lorazepam (Ativan), clorazepate (Tranxene), triazolam (Halcion), flurazepam (Dalmane), or temazepam (Restoril); or

• seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), phenobarbital (Luminal, Solfoton), and others.

If you are using any of these drugs, you may not be able to receive buprenorphine injection, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect buprenorphine injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about buprenorphine injection written for health professionals that you may read.

What does my medication look like?

Buprenorphine injection is available with a prescription under the brand name Buprenex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.