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|Brimonidine

Brimonidine

Brimonidine is used for:

Lowering eye pressure in patients with wide-angle glaucoma or high blood pressure of the eye.

Brimonidine is an alpha-3 adrenergic agonist. It works by lowering the fluid pressure inside the eyeball and increases fluid drainage from the eyeball.

Do NOT use Brimonidine if:

• you are allergic to any ingredient in Brimonidine
• you are currently taking furazolidone or an monoamine oxidase (MAO) inhibitor (eg, phenelzine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Brimonidine :

Some medical conditions may interact with Brimonidine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have severe heart disease (including not enough blood flow) or kidney or liver problems
• if you have a history of depression
• if you have Raynaud phenomenon
• if you have low blood pressure, inflammation of the blood vessels, or not enough blood flow to the brain

Some MEDICINES MAY INTERACT with Brimonidine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Bromocriptine, catechol-O-methyltranferase (COMT) inhibitors, cocaine, methyldopa, and oxytocic drugs (eg, ergotamine), because the risk of their side effects may be increased by Brimonidine
• Furazolidone and MAO inhibitors (eg, selegiline) because side effects, including high fever, high blood pressure, and headache, may be increased by Brimonidine
• Guanethidine because its effectiveness may be decreased by Brimonidine
• Tricyclic antidepressants (eg, amitriptyline), because they could increase or decrease Brimonidine "s effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Brimonidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Brimonidine :

Use Brimonidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Do not stop using Brimonidine or change the dose unless advised to do so by your health care provider.
• Remove soft contact lenses before you use Brimonidine ; lenses may be placed back in the eyes 15 minutes after use of Brimonidine .
• To use Brimonidine in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• Instill 1 drop into the affected eye(s) 3 times daily about 8 hours apart or as directed by your health care provider.
• More than 1 eye medicine may be used to lower eye pressure. Use the products at least 5 minutes apart.
• If your medicine comes with a special cap, follow the directions on how to use this properly.
• Do not use more medicine than prescribed unless advised to do so by your health care provider.
• Contact your health care provider at once if you feel you have used too much of Brimonidine .
• If you miss a dose of Brimonidine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Brimonidine .

Important safety information:

• Brimonidine may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Brimonidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Lab tests may be performed while you use Brimonidine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Brimonidine should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Brimonidine while you are pregnant. It is not known if Brimonidine is found in breast milk. If you are or will be breast-feeding while you use Brimonidine , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Brimonidine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal vision; cough; dizziness; drowsiness; dry eyes; dry mouth; eye irritation; flu; foreign body sensation; headache; inflamed eyelids; irritation near the eyelashes; loss of color in the eye; muscular pain; rash; redness of eyelid; runny nose; sensitivity to light; sinus infection; sore throat; staining and erosion of the cornea; stomach upset; swelling of the conjunctiva; tearing; tiredness; upper respiratory tract symptoms; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; changes in heart rate; difficulty breathing; eyelid crusting; fainting; nasal dryness; palpitations; pounding in the chest.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Brimonidine at room temperature, between 59 and 77 degrees F (15 and 20 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Brimonidine out of the reach of children and away from pets.

General information:

• If you have any questions about Brimonidine , please talk with your doctor, pharmacist, or other health care provider.
• Brimonidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Brimonidine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.