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Adipost, Anorex-SR, Appecon, Bontril PDM, Bontril Slow-Release, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex, |Bontril PDM

Bontril PDM

Generic Name: phendimetrazine (fen di MEH tra zeen)
Brand Names: Adipost, Anorex-SR, Appecon, Bontril PDM, Bontril Slow-Release, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex

What is phendimetrazine?

Phendimetrazine is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or "anorexigenic" drug. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity.

Phendimetrazine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about phendimetrazine?

Who should not take phendimetrazine?

• have heart disease or high blood pressure;

• have arteriosclerosis (hardening of the arteries);

• have glaucoma;

• have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or

• have a history of drug or alcohol abuse.

Before taking this medication, tell your doctor if you have

• problems with your thyroid,

• an anxiety disorder,

• epilepsy or another seizure disorder, or

• diabetes.

You may not be able to take phendimetrazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take phendimetrazine?

Take phendimetrazine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Do not take phendimetrazine in the evening because it may cause insomnia.

What happens if I miss a dose?

What happens if I overdose?

Symptoms of a phendimetrazine overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

What should I avoid while taking phendimetrazine?

Do not take phendimetrazine late in the day. A dose taken too late in the day can cause insomnia.

Phendimetrazine side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or

• hallucinations, abnormal behavior, or confusion.

Other, less serious side effects may be more likely to occur. Continue to take phendimetrazine and talk to your doctor if you experience

• restlessness or tremor,

• nervousness or anxiety,

• headache or dizziness,

• insomnia,

• dry mouth or an unpleasant taste in your mouth,

• diarrhea or constipation, or

• impotence or changes in your sex drive.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect phendimetrazine?

You cannot take phendimetrazine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.

Changes in insulin and other diabetes drug therapies may be necessary during treatment with phendimetrazine.

Phendimetrazine may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.

Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of phendimetrazine.

Drugs other than those listed here may also interact with phendimetrazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has more information about phendimetrazine written for health professionals that you may read.

What does my medication look like?

Phendimetrazine is available with a prescription under several brand names. The immediate-release formulation is available in 35 mg tablets and capsules. The sustained-release formulation is available in 105 mg capsules. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
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