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BiDil, |BiDil BiDil

BiDil

Generic Name: hydralazine and isosorbide dinitrate (hi dral LA zeen and I so zor bi da din eye treyt)
Brand Names: BiDil

What is hydralazine and isosorbide dinitrate?

Hydralazine is a vasodilator. It relaxes (widens) veins and arteries, which makes it easier for your heart to pump.

Isosorbide dinitrate is in a class of drugs called nitrates. Isosorbide dinitrate dilates (widens or relaxes) blood vessels (arteries and veins). When blood vessels are dilated, it is easier for the heart to pump. Also, more blood, which is rich in oxygen, can flow to the heart.

Hydralazine and isosorbide dinitrate is used to treat heart failure.

Hydralazine and isosorbide dinitrate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about hydralazine and isosorbide dinitrate?

You may develop a headache because of this medicine, but do not stop taking it. Take aspirin or acetaminophen to treat the headache. Ask your doctor which is best for you. This side effect usually goes away with continued hydralazine and isosorbide dinitrate treatment.

What should I discuss with my healthcare provider before taking hydralazine and isosorbide dinitrate?

Before taking this medication, tell your doctor if you

• have low blood pressure;

• have had a stroke, a transient ischemic attack (TIA, or mini-stroke), or a serious head injury;

• have anemia;

• have an allergy to nitrates;

• have closed-angle glaucoma;

• suffer from migraines;

• have systemic lupus erythematosus;

• have high levels of cholesterol or triglycerides (types of fat) in your blood;

• have pulmonary hypertension;

• have kidney disease; or
• have liver disease.

You may not be able to take hydralazine and isosorbide dinitrate, or you may require a dosage adjustment or special monitoring during therapy.

How should I take hydralazine and isosorbide dinitrate?

Take hydralazine and isosorbide dinitrate exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If your next regularly scheduled dose is within 2 hours, skip the dose you missed and take only the next dose. Do Not take a double dose of this medication.

What happens if I overdose?

Symptoms of an hydralazine and isosorbide dinitrate overdose include a severe throbbing headache, difficult or slow breathing, muscle cramps, nausea, vomiting, diarrhea, fever, dizziness, fainting, an irregular or slow heart beat, changes in vision, confusion, flushing, and seizures.

What should I avoid while taking hydralazine and isosorbide dinitrate?

Hydralazine and isosorbide dinitrate side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• blurred vision and dry mouth;

• irregular heartbeat; or

• blood in your urine or stools;

• numbness, tingling, pain, or weakness of your arms or legs;

• fainting.

Other, less serious side effects may be more likely to occur. If you experience any of the following side effects, continue to take isosorbide and talk to your doctor:

• headache or dizziness;

• flushing (redness of the face, neck and chest);

• nausea or vomiting;

• fast heartbeat;

• swollen ankles; or

• weakness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydralazine and isosorbide dinitrate?

Before taking hydralazine and isosorbide dinitrate, tell your doctor if you are taking any of the following medicines:

• dihydroergotamine (D.H.E. 45); or

• any other heart medicines, especially those used to treat high blood pressure or irregular heartbeats.

You may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with hydralazine and isosorbide dinitrate or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about hydralazine and isosorbide dinitrate written for health professionals that you may read.

What does my medication look like?

Hydralazine and isosorbide dinitrate is available with a prescription under the brand name BiDil. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• BiDil - 20mg isosorbide dinitrate / 37.5mg hydralazine - biconvex orange tablets.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.