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Kineret, |anakinra injectable

anakinra

Generic Name: anakinra (injectable) (an na KIN rah)
Brand Names: Kineret

What is anakinra?

Anakinra reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.

Anakinra is used to treat the symptoms of moderate to severe rheumatoid arthritis in patients who have had an inadequate response to one or more antirheumatic drugs. Anakinra may be used in combination with other antirheumatic medications.

Anakinra may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about anakinra?

What should I discuss with my healthcare provider before using anakinra?

• are currently taking etanercept (Enbrel), infliximab (Remicade), or adalimumab (Humira) to treat rheumatoid arthritis;

• have an active infection or a history of recurrent infection;

• have recently been exposed to varicella (chickenpox) virus;

• have a bone marrow disease;

• have a suppressed immune system due to a medical condition or treatment with medication;

• have recently received a live vaccine; or

• have kidney disease.

You may not be able to use anakinra, or you may require a dosage adjustment or special monitoring during treatment.

How should I use anakinra?

Use anakinra exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Anakinra is used as a subcutaneous (under the skin) injection only. Your doctor or nurse will give you detailed instructions on how and where to inject anakinra. Do not inject this medication if you are unsure how.

Anakinra is usually injected once a day. The dose should be injected at approximately the same time every day.

The medication may be allowed to reach room temperature by removing it from the refrigerator about 60 to 90 minutes before administration. This may reduce discomfort during or following the injection.

The medication can be injected into the outer thighs, stomach, back of the upper arms, or buttocks. Rotate the injection site daily to reduce the possibility of soreness or redness. The area of the body being injected does not need to change daily, however each injection site should be at least one inch from the previous day"s injection site.

Do not inject anakinra if it is discolored, cloudy, or if it has particles in it. Do not shake the prefilled syringe and do not use anakinra beyond the expiration date shown on the carton. If the solution appears foamy, allow it to sit for a few minutes until it clears.

This medication does not contain a preservative. Therefore, throw away any medication remaining in the syringe after a dose. Do not save the medication for later use.

Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture-resistant disposal container.

Your doctor may want you to have blood tests or other medical evaluations during treatment with anakinra to monitor progress and side effects.

Anakinra should be used on a regular basis to get the most benefit.

What happens if I miss a dose?

Notify your healthcare provider if you miss a dose of this medication.

What happens if I overdose?

Serious or life-threatening side effects are unlikely to occur from an overdose of anakinra. Contact your doctor or seek medical attention if an overdose of anakinra is suspected.

What should I avoid while using anakinra?

Anakinra side effects

Other less serious side effects may be more likely to occur. Continue to use anakinra and notify your doctor if you experience

• nausea or diarrhea;

• a headache;

• sinus irritation or infection; or

• redness, bruising, pain, or swelling at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect anakinra?

Before using anakinra, talk to your doctor if you are taking

• etanercept (Enbrel);

• infliximab (Remicade);

• adalimumab (Humira); or

• a medicine that may decrease the effects of the immune system.

You may not be able to use anakinra, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with anakinra. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has more information about anakinra written for health professionals that you may read.

What does my medication look like?

Anakinra is available with a prescription under the brand name Kineret. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Kineret 100 mg--prefilled glass syringe with 27 gauge needle (0.67 mL)

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.