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Aralast, Prolastin, Zemaira, |alpha 1-proteinase inhibitor

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alpha 1-proteinase inhibitor

Generic Name: alpha 1-proteinase inhibitor (AL fa one PRO tee nase in HIH bih tor)
Brand Names: Aralast, Prolastin, Zemaira

What is alpha 1-proteinase inhibitor?

Alpha 1-proteinase inhibitor is a naturally-occurring protein, also known as alpha 1-antitrypsin. Alpha 1-proteinase inhibitor is normally present in the body and is important for preventing the breakdown of tissues in the lungs. A congenital (hereditary) disorder known as alpha 1-proteinase deficiency may result in emphysema due to damaged tissue in the lungs.

Alpha 1-proteinase inhibitor is used in the treatment of congenital alpha 1-proteinase deficiency in patiens with symptoms of emphysema.

Alpha 1-proteinase inhibitor may also be used for purposes other than those listed here.

What is the most important information I should know about alpha 1-proteinase inhibitor?

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; low blood pressure; and dizziness; have occurred upon injection of alpha 1-proteinase inhibitor in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of alpha 1-proteinase inhibitor.

Alpha 1-proteinase inhibitor is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although alpha 1-proteinase inhibitor is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using alpha 1-proteinase inhibitor.

What should I discuss with my health care provider before using alpha 1-proteinase inhibitor?

Before using alpha 1-proteinase inhibitor, tell your doctor if you have

had an allergic reaction to alpha 1-proteinase inhibitor or have an IgA deficiency or antibody against IgA; or
other medical conditons or if you take other prescription or over-the-counter medicines, including vitamins, minerals, or herbal products.

You may not be able to use alpha 1-proteinase inhibitor, or you may require a dosage adjustment or special monitoring during treatment.

Alpha 1-proteinase inhibitor is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not use alpha 1-proteinase inhibitor without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether alpha 1-proteinase inhibitor passes into breast milk. Do not use alpha 1-proteinase inhibitor without first talking to your doctor if you are breast-feeding a baby.

How should I use alpha 1-proteinase inhibitor?

Use alpha 1-proteinase inhibitor exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Alpha 1-proteinase inhibitor is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.

Your doctor may prescribe other medications to be taken before receiving an alpha 1-proteinase inhibitor injection. These may help prevent or reduce the severity of an allergic or infusion reaction. Take these medications as directed by your healthcare provider.

Your doctor may want you to have blood tests or other medical evaluations during treatment with alpha 1-proteinase inhibitor to monitor progress and side effects.

Your healthcare provider will store alpha 1-proteinase inhibitor as instructed by the manufacturer. If you are storing alpha 1-proteinase inhibitor at home, your healthcare provider will give you instructions regarding how to store the medication.

What happens if I miss a dose?

Contact your doctor if you miss a dose of alpha 1-proteinase inhibitor.

What happens if I overdose?

Contact your doctor, a hospital emergency room, or a poison control center if an overdose is suspected.

Although symptoms of an alpha 1-proteinase inhibitor overdose are not known, an overdose is unlikely to threaten life.

What should I avoid while taking alpha 1-proteinase inhibitor?

There are no restrictions on food, beverages, or activity during treatment with alpha 1-proteinase inhibitor, unless otherwise directed by your doctor.

Alpha 1-proteinase inhibitor side effects

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; and low blood pressure have occurred upon injection of alpha 1-proteinase inhibitor in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of alpha 1-proteinase inhibitor.

Other less serious side effects such as fever; chills; headache; dizziness; redness, pain or swelling at the injection site have also been reported in a small number of patients. Talk to your doctor about any side effects that you experience.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect alpha 1-proteinase inhibitor?

Alpha 1-proteinase inhibitor is not known to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including herbal products, during treatment with alpha 1-proteinase inhibitor.

Where can I get more information?

Your pharmacist has more information about alpha 1-proteinase inhibitor written for health professionals that you may read.

What does my medication look like?

Alpha 1-proteinase inhibitor is available with a prescription under the brand names Prolastin and Aralast. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 2.01. Revision Date: 11/29/05 12:44:36 PM.

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