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Zyloprim, |allopurinol

allopurinol

Generic Name: allopurinol (al oh PURE i nole)
Brand Names: Zyloprim

What is allopurinol?

Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.

Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.

Allopurinol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about allopurinol?

Allopurinol can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

What should I discuss with my healthcare provider before taking allopurinol?

• kidney disease;

• liver disease;

• diabetes;

• congestive heart failure;

• high blood pressure; or

• if you are receiving any chemotherapy.

If you have any of these conditions, you may not be able to use allopurinol, or you may need a dosage adjustment or special tests during treatment.

How should I take allopurinol?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Allopurinol can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of allopurinol is not expected to produce life-threatening symptoms.

What should I avoid while taking allopurinol?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Your doctor may recommend a special diet to help treat your condition. Follow your diet and medication routines very closely.

Allopurinol side effects

• the first sign of any skin rash, no matter how mild;

• pain or bleeding when you urinate;

• urinating less than usual or not at all;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• bruising, severe tingling, numbness, pain, muscle weakness;

• easy bruising or bleeding, unusual weakness;

• fever, chills, body aches, flu symptoms;

• jaundice (yellowing of the skin or eyes); or

• seizure (convulsions).

Keep taking allopurinol and talk to your doctor if you have any of these less serious side effects:

• nausea, vomiting, diarrhea;

• dizziness or drowsiness;

• increased sweating; or

• joint pain.

Side effects other than those listed here may also occur. Talk to your doctor about any reaction that seems unusual or that is especially bothersome.

What other drugs will affect allopurinol?

Before taking allopurinol, tell your doctor if you are using any of the following drugs:

• azathioprine (Imuran);

• chlorpropamide (Diabinese);

• cyclosporine (Gengraf, Sandimmune, Neoral);

• mercaptopurine (Purinethol);

• an antibiotic such as ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox);

• a blood thinner such as dicoumarol or warfarin (Coumadin); or

• a diuretic (water pill) such as chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others.

If you are using any of these drugs, you may not be able to use allopurinol, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect allopurinol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about allopurinol written for health professionals that you may read.

What does my medication look like?

Allopurinol is available with a prescription under the brand name Zyloprim. Other brand or generic forms may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.