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Adefovir
Generic Name: Adefovir (ah-DEF-oh-veer)
Brand Name: Hepsera
Severe worsening of hepatitis (rarely including death) has occurred when Adefovir has been stopped. If you are instructed to stop taking Adefovir , your doctor will monitor you closely for signs of worsening hepatitis. Be sure to keep all doctor and lab appointments after you stop taking Adefovir . Infrequently, severe, even fatal, liver and blood acid-base balance problems (lactic acidosis) have been associated with Adefovir . These side effects may be more likely to occur if you are very overweight or are using a similar type of medicine. Notify your doctor immediately if you develop unusual weakness or fatigue, dark urine, yellowing of the skin or eyes, light-colored stools, loss of appetite, abdominal or stomach pain with or without nausea or vomiting, drowsiness, muscle aches or weakness, dizziness, lightheadedness,
coldness (especially in the arms or legs), trouble breathing, or fast or irregular heartbeat. Adefovir may cause severe kidney problems. Notify your doctor immediately if you develop a change in the amount of urine that you produce. Use of Adefovir for hepatitis B infection in patients with untreated or unknown HIV infection may result in strains of the HIV virus resistant to treatment. |
Adefovir is used for:Treating chronic hepatitis B virus infection.
Adefovir is a nucleotide analog. It works by slowing the growth of the virus. It is not a cure for hepatitis B.
Do NOT use Adefovir if:
- you are allergic to any ingredient in Adefovir
- you have an enlarged liver, abnormal liver function tests, or blood-acid base balance problems (lactic acidosis)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Adefovir :Some medical conditions may
interact with Adefovir . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are overweight or have kidney or liver problems, have had liver transplant, or have HIV infection
Some MEDICINES MAY INTERACT with Adefovir . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Nucleoside analogs (eg, didanosine, lamivudine) because risk of lactic acidosis or severe liver problems may be increased
- Medicines that may harm your kidneys (eg, aminoglycosides [eg,
gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin)
because risk of severe kidney problems may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Adefovir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Adefovir :Use Adefovir as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Adefovir may be taken with or without food.
- Adefovir comes with an additional patient leaflet. Read it carefully and reread it each time you get Adefovir refilled.
- Adefovir works best if it is taken at the same time each day.
- Continue to use Adefovir even if you feel well. Do not miss any doses.
- If you miss a dose of Adefovir , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Adefovir .
Important safety information:
- When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. This virus may develop resistance to Adefovir if you stop taking it, even for a short period of time or may make the virus harder to treat.
- Adefovir will not cure chronic hepatitis B. It may help reduce the amount of hepatitis B virus in your body.
- Adefovir offers no protection from the transmission of hepatitis B to others through sexual contact or blood contamination. Use barrier forms of contraception
(eg, condoms) if you are infected with hepatitis B. Do not share needles or other injection items. Do not share personal items that may have blood or body fluids on them, such as toothbrushes or razor blades.
- You should be tested for HIV before taking Adefovir and anytime there is a chance that you are exposed to HIV. If you have or contract HIV that is not being treated, Adefovir may stop usual HIV medicines from controlling your HIV infection.
- Worsening of your condition, decreased response to Adefovir , or development of resistant strains of the virus may occur during or after treatment. Tell your doctor immediately if any new symptoms occur during or after treatment.
- LAB TESTS, including liver and kidney function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use Adefovir with caution in the ELDERLY because they may be more
sensitive to its effects.
- Adefovir is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Adefovir during pregnancy. It is unknown if Adefovir is excreted in breast milk. Do not breast-feed while taking Adefovir .
Possible side effects of Adefovir :All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea; fever; gas; headache; increased cough; indigestion; nausea;
sore throat; stomach upset; vomiting. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing;
tightness in the chest; swelling of the mouth, face, lips, or tongue); buildup of acid in the blood (weakness; unusual muscle pain;
difficulty breathing;
stomach pain with nausea and vomiting; cold arms and legs; dizziness or lightheadedness;
fast or irregular heartbeat); change in the amount of urine you produce; drowsiness;
liver toxicity (yellowing of the skin or eyes; dark urine; light-colored bowel movements; loss of appetite; nausea; lower stomach pain); unusual weakness or fatigue.
This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.
Proper storage of Adefovir :Store this
medicine at 77 degrees F (25 degrees C) in the original container. Store away from heat, moisture, and light. Do not use if seal over bottle opening is broken or missing. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Adefovir out of the reach of children and away from pets.
General information:
- If you have any questions about Adefovir , please talk with your doctor, pharmacist, or other health care provider.
- Adefovir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Adefovir . If you have questions about the medicine you are taking or would like more information, check with your doctor,
pharmacist, or other health care provider.
Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.
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