Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets

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Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets


Generic Name: Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets (ah-seet-ah-MIN-oh-fen/klor-fen-EER-a-meen/fen-ill-EF-rin/fen-ill-tole-OX-a-meen)
Brand Name: Norel SR

Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets is used for:

Relieving symptoms of colds, hay fever, and allergies such as headache, sinus pain, nasal and sinus congestion, sneezing, watery eyes, runny nose, fever, and itching of the nose or throat. It may also be used for other conditions as determined by your doctor.

Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets is an antihistamine, decongestant, and pain reliever combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion and pain associated with sinus pressure, and dries the nose and chest.

Do NOT use Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets if:

  • you are allergic to any ingredient in Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets
  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets:

Some medical conditions may interact with Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of breathing problems (eg, emphysema, asthma), heart disease, diabetes, difficulty urinating, an enlarged prostate, glaucoma, high blood pressure, an overactive thyroid, liver or kidney problems, adrenal gland problems (eg, pheochromocytoma), sleep apnea, trouble sleeping, stomach problems, urinary blockage, increased eye pressure, or viral hepatitis
  • if you regularly drink large amounts of alcohol

Some MEDICINES MAY INTERACT with Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), droxidopa, isoniazid, furazolidone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects may be increased
  • Anticoagulants (eg, warfarin), bromocriptine, furazolidone, MAO inhibitors (eg, phenelzine), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because their actions and side effects may be increased by Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets
  • Certain high blood pressure medicines such as beta-blockers (eg, atenolol) and guanethidine because their effectiveness may be decreased by Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets:

Use Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets may be taken with food if it upsets your stomach.
  • Swallow Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of this medicine may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • If you miss a dose of Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets.

Important safety information:

  • Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets. Using Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Do not exceed the recommended dose of Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets. Doing so will not improve your condition faster and may increase your risk for side effects.
  • If your symptoms do not improve within a few days or if they become worse, check with your doctor.
  • Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets contains acetaminophen and phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen or phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Do not take diet or appetite control medicines while you are taking Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets without checking with your doctor.
  • If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets may increase your risk for liver damage.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets.
  • Caution is advised when using Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets in the ELDERLY because they may be more sensitive to its effects.
  • Use Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets can cause harm to the fetus. If you become pregnant while taking Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets, discuss with your doctor the benefits and risks of using Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets during pregnancy. Some of the ingredients in Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets are excreted in breast milk. If you are or will be breast-feeding while you are using Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine or pale stools; difficulty urinating; hallucinations; high blood pressure; rapid pulse; severe nervousness; stomach pain; tremors; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include fast or irregular heartbeat; fever; hallucinations; nausea; seizures; sweating; tremors; trouble breathing; unusual drowsiness or dizziness; vomiting.

Proper storage of Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets:

Store Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Acetaminophen/Chlorpheniramine/Phenylephrine/Phenyltoloxamine Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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