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Generic Name: Quinapril (KWIN-uh-pril)
Brand Name: Accupril

Accupril can cause injury and possibly death to a developing fetus when used after the third month of pregnancy. Talk with your doctor at once if you suspect that you are pregnant.

Accupril is used for:

Lowering high blood pressure and managing heart failure. It is used alone or with other medicines.

Accupril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is involved in certain chemical reactions that constrict (narrow) blood vessels and cause sodium and fluid retention by the kidney. This can cause an increase in blood pressure. ACE inhibitors lower elevated blood pressure by interfering with ACE and cause blood vessels to relax (widen). Blood flows more freely and at a lower pressure. ACE inhibitors also increase the heart"s ability to pump blood in some types of heart failure.

Do NOT use Accupril if:

  • you are allergic to any ingredient in Accupril
  • you are in the second or third trimester of pregnancy
  • you have a history of angioedema (swelling of the face, lips, throat, or tongue) caused by treatment with an ACE inhibitor

Contact your doctor or health care provider right away if any of these apply to you.

Before using Accupril :

Some medical conditions may interact with Accupril . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are a female of childbearing age
  • if you have heart disease, blood-flow problems, bone marrow depression, or kidney disease
  • if you have had a stroke or a kidney transplant or are on dialysis
  • if you have an autoimmune disease, lupus, or scleroderma (hardening of the skin)
  • if you have imbalances of sodium or potassium or are on a sodium restricted diet
  • if you are scheduled to have major surgery

Some MEDICINES MAY INTERACT with Accupril . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) or salicylates (eg, aspirin) because they may decrease Accupril "s effectiveness
  • Clozapine, cyclosporine, dextran sulfate, HMG-CoA reductase inhibitors (eg, simvastatin), mannitol, NSAIDs (eg, ibuprofen, indomethacin), pergolide, phenothiazines (eg, thioridazine), potassium preparations, potassium-sparing diuretics (eg, spironolactone), thiazide diuretics (eg, hydrochlorothiazide), or trimethoprim because side effects, such as low blood pressure or increased potassium levels leading to heart attack, may occur
  • Clozapine, iron salts (eg, ferrous sulfate), lithium, NSAIDs (eg, ibuprofen, indomethacin), potassium preparations, potassium-sparing diuretics (eg, spironolactone), sulfonylureas (eg, glipizide), thiazide diuretics (eg, hydrochlorothiazide), or thiopurines (eg, azathioprine) because he risk of their side effects may be increased by Accupril

This may not be a complete list of all interactions that may occur. Ask your health care provider if Accupril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Accupril :

Use Accupril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Accupril by mouth on an empty stomach at least 1 hour before or 2 hours after eating, or with a light meal. High-fat meals, however, may decrease the absorption of the medicine into your bloodstream.
  • If you are taking a tetracyclines (eg, doxycycline) or fluoroquinolones (eg, ciprofloxacin), take it at least 3 hours apart from Accupril . This product contains magnesium, which can interfere with absorption of these antibiotics.
  • If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. If more than one dose is missed, contact your health care provider or pharmacist.

Ask your health care provider any questions you may have about how to use Accupril .

Important safety information:

  • Accupril may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Accupril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Accupril has magnesium in it. Before you start any new medicine, check the label to see if it has magnesium in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Accupril may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Accupril . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
  • Accupril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • Tell your doctor or dentist that you take Accupril before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including electrolyte levels, may be performed while you use Accupril . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Accupril should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Accupril if you are pregnant. It has been shown to cause death to the fetus and newborn. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Accupril is found in the breast milk. If you are or will be breast-feeding while you use Accupril , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Accupril :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chest pain; coughing; diarrhea; difficulty breathing; dizziness; headache; lightheadedness; nausea; persistent, dry cough; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty swallowing or breathing; fainting; hoarseness; infection (sore throat, fever); irregular or slow heartbeat; shortness of breath; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include: extreme dizziness; low blood pressure; weakness.

Proper storage of Accupril :

Store Accupril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Protect from moisture, heat, and light. Do not store in the bathroom. Keep Accupril out of the reach of children and away from pets.

General information:

  • If you have any questions about Accupril , please talk with your doctor, pharmacist, or other health care provider.
  • Accupril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Accupril . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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