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|Vecuronium Bromide |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Vecuronium BromidePronouncation: (veh-CUE-row-nee-uhm BROE-mide)Class: Nondepolarizing neuromuscular blocker Trade Names: Mechanism of ActionPharmacologyCauses paralysis of skeletal muscles by binding competitively to cholinergic receptors on motor end-plate to antagonize action of acetylcholine, resulting in block of neuromuscular transmission. PharmacokineticsDistributionAbout 60% to 80% bound to plasma proteins. Distribution t ½ is about 4 min. Vd is 300 to 400 mL/kg. MetabolismOne metabolite, 3-desacetyl vecuronium, has been recovered in urine of some patients in quantities that account for up to 10% of an injected dose. 3-desacetyl vecuronium also has been recovered by T-tube in some patients accounting for up to 25% of the injected dose. EliminationThe t ½ is 65 to 75 min. In late pregnancy, the t ½ is about 35 to 40 min. Systemic rate of clearance is about 3 to 4.5 mL/min/kg. Urine recovery varies from 3% to 35% within 42 hr. Indications and UsageAdjunct to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. ContraindicationsHypersensitivity to vecuronium or bromides. Dosage and AdministrationAdults & Children younger than 10 yr of ageIV Initial dose: for inhalation 0.08 to 0.1 mg/kg. Reduce initial dose by 15% (0.06 to 0.85 mg/kg) if inhalation agents are already in use. If intubation is performed using succinylcholine, reduce initial dose to 0.04 to 0.06 mg/kg with inhalation anesthesia and 0.05 to 0.06 mg/kg with balanced anesthesia. Maintenance: IV bolus 0.01 to 0.015 mg/kg within 25 to 40 min of initial dose, then q 12 to 15 min. IV infusion: 1 mcg/kg/min initially beginning 20 to 40 min after IV bolus. Titrate to desired clinical response. Children 1 to 10 yr of ageIV Slightly higher initial doses and more frequent supplementation. Infants 7 wk to 1 yr of ageIV Slightly lower doses and 1.5 times less frequent. General Advice
Storage/StabilityStore unopened vial at room temperature. Protect from light. Following reconstitution, refrigerate. Use within 8 hr. Intended for single use only. Discard unused portions. Drug InteractionsAminoglycosides, verapamil, inhalation anesthetics (eg, enflurane, isoflurane), lincosamides (eg, clindamycin, lincomycin), magnesium salts, polypeptide antibiotics (eg, bacitracin, polymyxin B)May enhance action of vecuronium (eg, respiratory depression). Hydantoins, carbamazepineMay cause vecuronium to have shorter duration or decreased effectiveness. Quinidine, quinineRecurrent paralysis may occur with injection of quinidine during recovery from use of other muscle relaxants. TheophyllinesDose-dependent reversal of neuromuscular blockade is possible. Thiopurines (eg, mercaptopurine)May decrease or reverse vecuronium action. TrimethaphanMay cause prolonged apnea. Laboratory Test InteractionsNone well documented. Adverse ReactionsRespiratoryRespiratory insufficiency; apnea. MiscellaneousSkeletal muscle weakness; profound and prolonged skeletal muscle paralysis. Precautions
PregnancyCategory C . LactationUndetermined. ChildrenInfants are moderately more sensitive and take longer to recover. Not recommended in newborns; diluent contains benzyl alcohol (fatal-gasping syndrome). ElderlyMay experience delayed onset of action. Circulatory disease (eg, cardiovascular disease, elderly, edematous states)May cause delayed onset of action, do not increase dosage. ConsciousnessVecuronium has no known effect on consciousness, pain threshold, or cerebration. Accompany administration of this drug by adequate anesthesia. Electrolyte imbalanceNeuromuscular blockade may be altered depending on nature of imbalance. Hepatic/Renal/Biliary diseaseProlonged neuromuscular blockade may occur due to reduced elimination. Higher doses may be needed due to increased volume of distribution. Malignant hyperthermiaMonitor patient closely. Myasthenia gravisSmall doses may have profound effects; administer test dose in monitoring response to muscle relaxants. Severe obesity or neuromuscular diseaseMay pose airway or ventilation problems requiring special care before, during, or after vecuronium. OverdosageSymptomsSkeletal muscle weakness, neuromuscular block beyond time needed, hypotension, decreased respiratory reserve, low tidal volume, apnea. Patient Information
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