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Tygacil, |Tygacil Tygacil

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Tygacil

Generic Name: tigecycline (tye ge SYE kleen)
Brand Names: Tygacil

What is tigecycline?

Tigecycline is a tetracycline-like antibiotic. It fights bacteria in the body.

Tigecycline is used to treat many different bacterial infections of the skin or the digestive system.

Tigecycline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about tigecycline?

Do not use this medication if you are pregnant. Babies born to mothers who use tigecycline during late pregnancy can have permament tooth discoloration. Do not use tigecycline without your doctor"s consent if you are pregnant. Tell your doctor if you become pregnant during treatment.

Tigecycline can make birth control pills less effective. Use a second method of birth control while you are using tigecycline to keep from getting pregnant.

It is not known whether tigecycline passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Children younger than 8 years old should not use tigecycline. Tigecycline can cause permanent tooth discoloration. Before using tigecycline, tell your doctor if you have liver disease, or if you are allergic to antibiotics such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Tigecycline is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to use your injections at home. Do not use this medicine at home if you do not fully understand how to mix the medication, give the injection, and properly dispose of needles and other items used in giving the medicine.

Use this medication for the entire length of time prescribed by your doctor. You may need to use the medication for as long as 2 weeks. Your symptoms may get better before the infection is completely treated. Tigecycline will not treat a viral infection such as the common cold or flu. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Tigecycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

What should I discuss with my healthcare provider before using tigecycline?

Do not use this medication if you are allergic to tigecycline. Before using tigecycline, tell your doctor if you have liver disease, or if you are allergic to antibiotics such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Do not use this medication if you are pregnant. Babies born to mothers who use tigecycline during late pregnancy can have permament tooth discoloration. Do not use tigecycline without your doctor"s consent if you are pregnant. Tell your doctor if you become pregnant during treatment.

Tigecycline can make birth control pills less effective. Use a second method of birth control while you are using tigecycline to keep from getting pregnant.

How should I use tigecycline?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

This medication comes in a powder form that must be mixed with a liquid (diluent) such as sodium chloride or dextrose. After mixing, the liquid should appear as a yellow or orange color. Do not use the medication if it has changed colors to green or black, or if it has any particles in it. Call your doctor for a new prescription.

Use each needle and syringe only one time. With your medicine you will receive a puncture-proof container for used needles and syringes. If you do not receive a container, ask your pharmacist for one. Keep this container out of the reach of children and pets. Your pharmacist can tell you how to properly dispose of the container.

Use this medication for the entire length of time prescribed by your doctor. You may need to use the medication for as long as 2 weeks. Your symptoms may get better before the infection is completely treated. Tigecycline will not treat a viral infection such as the common cold or flu. Store the unmixed powder medicine at room temperature away from moisture and heat. Once the medicine has been mixed, you may store it at room temperature as long as you use it within 6 hours. The mixed medicine may also be stored in a refrigerator and used within 24 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a tigecycline overdose may include nausea and vomiting.

What should I avoid while using tigecycline?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Tigecycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Tigecycline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using tigecycline and call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody;
severe headache, pain behind your eyes, ringing or throbbing in your ears, problems with vision, and nausea or vomiting;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
feeling light-headed, fainting; or
easy bruising or bleeding, unusual weakness.

Continue using tigecycline and talk with your doctor if you have any of these less serious side effects:

mild stomach pain, nausea, vomiting, or diarrhea;
dizziness, sleep problems (insomnia);
increased sweating; or
vaginal yeast infection.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect tigecycline?

Do not give any of the following drugs through the same IV line used to give your tigecycline injection:

amphotericin B (Abcelet, Ambisome, Fungizone);
chlorpromazine (Ormazine, Thorazine);
methylprednisolone (A-Methapred, Depo-Medrol, Duralone, Solu-Medrol); or
voriconazole (Vfend).

There may be other drugs not listed that can affect tigecycline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about tigecycline written for health professionals that you may read.

What does my medication look like?

Tigecycline is available with a prescription under the brand nameTygacil. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.01. Revision Date: 10/3/06 1:20:02 PM.

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