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|Trimetrexate |
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In Canada—
Category
DescriptionTrimetrexate (tri-me-TREX-ate) is used, together with leucovorin (loo-koe-VOR-in), to treat Pneumocystis carinii ((noo-moe-SISS-tis)) pneumonia (PCP), a very serious kind of pneumonia. This kind of pneumonia occurs commonly in patients whose immune system is not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS). Trimetrexate may cause some serious, even life-threatening, side effects. To prevent these effects, you must take another medicine, leucovorin, together with trimetrexate and for 3 days after you stop receiving trimetrexate. Before you begin treatment with trimetrexate, you and your doctor should talk about the good this medicine will do as well as the risks of using it. Trimetrexate is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage form:
Before Receiving This MedicineIn deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trimetrexate, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to trimetrexate, methotrexate, or leucovorin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy—Use of trimetrexate during pregnancy should be avoided whenever possible since trimetrexate has caused birth defects and death of the fetus in animal studies. The use of birth control is recommended during trimetrexate therapy. Tell your doctor immediately if you think you may be pregnant or if you need advice about birth control. Breast-feeding—It is not known if trimetrexate passes into breast milk. However, breast-feeding should be stopped during treatment with this medicine because trimetrexate may cause serious unwanted effects in nursing babies. Children—This medicine has been tested in a limited number of children younger than 18 years of age. Trimetrexate can cause serious side effects in any patient. However, in effective doses, this medicine did not cause different side effects or problems in the few children who received it than it does in adults. Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of trimetrexate in the elderly with use in other age groups. Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking trimetrexate, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of trimetrexate. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This MedicineWhen you take leucovorin :
Dosing—The doses of trimetrexate and of leucovorin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of trimetrexate and leucovorin. If your doses are different, do not change them unless your doctor tells you to do so.
Missed dose—If you miss a dose of leucovorin, take it as soon as possible. This will help to keep a constant amount of medicine in the blood. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage—To store leucovorin:
Precautions While Receiving This MedicineIf your symptoms do not improve within a few days, or if they become worse, check with your doctor. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. Trimetrexate can lower the number of white blood cells in your blood temporarily, increasing your chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
Check with your doctor right away if you experience symptoms of an allergic reaction such as cough, difficulty swallowing, dizziness, fainting or loss of consciousness, fast heartbeat, fast or irregular breathing, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips or tongue, shortness of breath, skin rash, swelling of eyes or eyelids, tightness in chest, trouble in breathing, unusual tiredness or weakness, and/or wheezing Side Effects of This MedicineAlong with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal pain or tenderness; black, tarry stools; blood in urine or stools; clay colored stools; dark urine; decreased appetite; fever and sore throat; headache; itching; loss of appetite; nausea and vomiting; pinpoint red spots on skin; skin rash; swelling of feet or lower legs; unusual bleeding or bruising; unusual tiredness or weakness; yellow eyes or skin Less common Abdominal cramps; coma; confusion; convulsions; decreased urine output; difficulty in breathing; dizziness; fast or irregular heartbeat; hypocalcemia; increased thirst; mood or mental changes; muscle cramps in hands, arms, feet, legs, or face; muscle pain ; mouth sores or ulcers; numbness and tingling around the mouth, fingertips, or feet; skin rash and itching; shortness of breath; tremor Rare Cough; difficulty swallowing; fainting or loss of consciousness; fast or irregular breathing; hives; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; swelling of eyes or eyelids; tightness in chest; trouble in breathing; wheezing Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: Less common Fatigue; stomach pain Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Additional InformationOnce a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, trimetrexate is used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use. Revised: 01/12/2006 The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products. Where can I get more information about Trimetrexate ? We recommend to use www.Drugs.com Typical mistypes for Trimetrexate rrimetrexate, frimetrexate, grimetrexate, yrimetrexate, 6rimetrexate, 5rimetrexate, teimetrexate, tdimetrexate, tfimetrexate, ttimetrexate, t5imetrexate, t4imetrexate, trumetrexate, trjmetrexate, trkmetrexate, trometrexate, tr9metrexate, tr8metrexate, trinetrexate, triketrexate, trijetrexate, trimwtrexate, trimstrexate, trimdtrexate, trimrtrexate, trim4trexate, trim3trexate, trimerrexate, trimefrexate, trimegrexate, trimeyrexate, trime6rexate, trime5rexate, trimeteexate, trimetdexate, trimetfexate, trimettexate, trimet5exate, trimet4exate, trimetrwxate, trimetrsxate, trimetrdxate, trimetrrxate, trimetr4xate, trimetr3xate, trimetrezate, trimetrecate, trimetredate, trimetresate, trimetrexzte, trimetrexste, trimetrexwte, trimetrexqte, trimetrexare, trimetrexafe, trimetrexage, trimetrexaye, trimetrexa6e, trimetrexa5e, trimetrexatw, trimetrexats, trimetrexatd, trimetrexatr, trimetrexat4, trimetrexat3, rimetrexate, timetrexate, trmetrexate, trietrexate, trimtrexate, trimerexate, trimetexate, trimetrxate, trimetreate, trimetrexte, trimetrexae, trimetrexat, rtimetrexate, tirmetrexate, trmietrexate, triemtrexate, trimterexate, trimertexate, trimeterxate, trimetrxeate, trimetreaxte, trimetrextae, trimetrexaet, ttrimetrexate, trrimetrexate, triimetrexate, trimmetrexate, trimeetrexate, trimettrexate, trimetrrexate, trimetreexate, trimetrexxate, trimetrexaate, trimetrexatte, trimetrexatee, etc.
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