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|Ticlopidine Hydrochloride |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Ticlopidine HydrochloridePronouncation: (tie-KLOE-pih-DEEN HIGH-droe-KLOR-ide)Class: Antiplatelet Trade Names: Gen-Ticlopidine (Canada) Nu-Ticlopidine (Canada) PMS-Ticlopidine (Canada) Rhoxal-ticlopidine (Canada) Mechanism of ActionPharmacologyProduces time- and dose-dependent inhibition of both platelet aggregation and release of platelet granule constituents as well as prolongation of bleeding time; interferes with platelet membrane function by inhibiting platelet-fibrinogen binding and subsequent platelet-platelet interactions. PharmacokineticsAbsorptionTiclopidine is rapidly absorbed with peak levels (T max ) occurring about 2 hr after dose. The drug is greater than 80% absorbed. Administration after meals results in a 20% increase in the AUC. Ticlopidine is 98% bound to plasma proteins. MetabolismTiclopidine is metabolized extensively by the liver; only trace amounts are detected in urine. EliminationTiclopidine t ½ is 4 to 5 days. Special PopulationsHepatic Function ImpairmentAverage plasma concentration is slightly higher in cirrhosis. Indications and UsageReduction of risk of thrombotic stroke in patients who have experienced stroke precursors and in patients who have had completed thrombotic stroke. Reserved for patients intolerant to aspirin because of greater risk of adverse reactions. Unlabeled UsesImproved walking distance in intermittent claudication; vascular improvement in chronic arterial occlusion; reduced incidence of neurologic deficit in subarachnoid hemorrhage; reduced incidence of vascular occlusion in uremic patients with arteriovenous shunts or fistulas; control of platelet count in open heart surgery; decreased graft occlusion in coronary artery bypass grafts; reduced degree of proteinuria and hematuria in primary glomerulonephritis; reduced incidence, duration, and severity of infarctive crises in sickle cell disease. ContraindicationsPresence of hematopoietic disorders (eg, neutropenia, thrombocytopenia); history of thrombotic thrombocytopenic purpura (TTP); presence of hemostatic disorder or active pathologic bleeding (eg, bleeding, peptic ulcer, intracranial bleeding, hemophilia, other coagulation defects); severe liver impairment. Dosage and AdministrationAdultsPO 250 mg bid with food. Storage/StabilityStore at room temperature. Drug InteractionsAntacidsMay reduce ticlopidine absorption. AspirinIncreased effect of aspirin on collagen-induced platelet aggregation. CimetidineElevated ticlopidine levels with possible increase in therapeutic and toxic effects. TheophyllineElevated serum theophylline concentrations, increasing risk of toxicity. PhenytoinElevated phenytoin plasma levels with associated somnolence and lethargy have been reported. Exercise caution when administering with ticlopidine. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularVasculitis. CNSHeadache; peripheral neuropathy; dizziness. DermatologicMaculopapular or urticarial rash; rash; pruritus. EENTTinnitus. GIDiarrhea; nausea; fullness; dyspepsia; GI pain; purpura; vomiting; flatulence; anorexia. GenitourinaryNephrotic syndrome. HematologicProlonged bleeding time; bleeding complications (ecchymosis, epistaxis, hematuria, conjunctival hemorrhage, GI bleeding, perioperative bleeding); neutropenia; pancytopenia; hemolytic anemia; serum sickness; immune thrombocytopenia; abnormal LFTs; TTP; agranulocytosis; eosinophilia; bone marrow depression. HepaticHepatitis; cholestatic jaundice; increased alkaline phosphatase, serum transaminases, and bilirubin. MetabolicIncreased cholesterol and triglycerides. MiscellaneousWeakness; pain; allergic pneumonitis; systemic lupus erythematosus; arthropathy; myositis; hyponatremia; aplastic anemia; hepatic necrosis; peptic ulcer; renal failure; sepsis; angioedema; hepatocellular jaundice. Precautions
PregnancyCategory B . LactationUndetermined. ChildrenSafety and efficacy in children under 18 yr not established. ElderlyRequire dosage reduction. HypersensitivityReactions range from minor to life-threatening. Renal FunctionDosage reduction or discontinuation of therapy may be required if hemorrhagic or hematopoietic complications occur. Hepatic FunctionUse not recommended because patient may have preexisting bleeding diathesis. Cholesterol elevationMay cause increased serum cholesterol and triglycerides. GI bleedingUse with caution in patients who have lesions with a propensity to bleed. Hematologic effectsFatal reactions (eg, pancytopenia) have occurred. Increased bleeding riskUse with caution in patients who may be at risk of increased bleeding from trauma, surgery, or pathological conditions. OverdosageSymptomsIncreased bleeding time, increased ALT. Patient Information
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