ticlopidine
 Ticlopidine

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Ticlid, |ticlopidine Ticlopidine

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ticlopidine

Generic Name: ticlopidine (oral) (tye KLOE pih deen)
Brand Names: Ticlid

What is ticlopidine?

Ticlopidine prevents substances in the blood, called platelets, from clustering. This helps to prevent blood clots from forming.

Ticlopidine is used to prevent strokes in patients who have had a stroke or who have experienced transient ischemic attacks (TIAs or "mini-strokes").

Although not approved by the FDA for these purposes, ticlopidine has also been used to reduce the rate of reocclusion of arteries following angioplasty or stent placement, and to reduce the chance of a heart attack in some patients with coronary artery disease.

Ticlopidine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about ticlopidine?

It may take longer than usual for you to stop bleeding, even from minor wounds. Contact your doctor if you experience unusual, prolonged, or severe bleeding or bruising.

Treatment with ticlopidine may reduce the number of white blood cells in your body (called neutropenia), which could lead to infection. If caught early, this side effect can be reversed, but if undetected, it can be fatal. Notify your doctor immediately if you develop signs of infection including fever, chills, or a sore throat. Ticlopidine may also cause a decrease in platelets (called thrombocytopenia). This may occur as part of a syndrome called TTP that includes injury to red blood cells, causing anemia, kidney problems, neurologic changes, fever, and possibly death. Notify your doctor immediately if you develop signs of TTP including yellow skin or eye color, pinpoint dots (rash) on the skin, pale color, fever, weakness on a side of the body, or dark urine. Also, some people may develop jaundice (liver damage) while taking ticlopidine. Notify your doctor immediately if you develop yellowing of the skin or the whites of the eyes, dark-yellow urine, or light-colored stools.

Your doctor will need to monitor your blood with blood tests before starting treatment with ticlopidine and every 2 weeks for the first 3 months of treatment. If your treatment with ticlopidine is stopped within the first three months of treatment, you will still need a blood test two weeks after stopping the medication.

Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, others), naproxen (Aleve, Anaprox, Naprosyn, others), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), or other non-steroidal anti-inflammatory medications (NSAIDs) without first talking to your doctor.

Tell your doctor and dentist that you are taking this medication before undergoing any surgical procedures.

What should I discuss with my healthcare provider before taking ticlopidine?

Do not take ticlopidine without first talking to your doctor if you have
  • had an allergic reaction to ticlopidine,

  • active bleeding anywhere in your body {such as bleeding in the stomach from an ulcer or a stroke of a certain type (bleeding in the head)},

  • a blood disorder or a bleeding problem including neutropenia or thrombocytopenia, or

  • been told that you had TTP.

Before taking ticlopidine, tell your doctor if you have:

  • a stomach or intestinal ulcer,

  • high levels of cholesterol or triglycerides (types of fat) in your blood,

  • kidney disease,
  • liver disease, or
  • recently had, or need to have, surgery (including dental surgery).

You may not be able to take ticlopidine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Ticlopidine is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether ticlopidine passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take ticlopidine?

Take ticlopidine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take ticlopidine with food or just after eating to lessen stomach upset.

Your doctor will need to monitor your blood with blood tests before starting treatment with ticlopidine and every 2 weeks for the first 3 months of treatment. If your treatment with ticlopidine is stopped within the first three months of treatment, you will still need a blood test two weeks after stopping the medication.

Store ticlopidine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a ticlopidine overdose are unknown but might include vomiting, difficulty breathing, blood in the vomit or stool, seizures, and loss of coordination.

What should I avoid while taking ticlopidine?

Do not take aspirin, ibuprofen (Motrin, Advil, Nuprin, others), naproxen (Aleve, Anaprox, Naprosyn, others), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), or other nonsteroidal anti-inflammatory drugs (NSAIDs) without first talking to your doctor.

Tell your doctor and dentist that you are taking this medication before undergoing any surgical procedures.

Ticlopidine side effects

If you experience any of the following serious side effects, stop taking ticlopidine and seek emergency medical attention or notify your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • bloody or black vomit or stools;

  • unusual, prolonged, or severe bleeding or bruising;

  • fever, chills, a sore throat, or other signs of infection;

  • a rash (including pinpoint dots on the skin);

  • yellow skin or eyes;

  • abdominal pain;

  • dark-yellow urine;

  • light-colored stools;

  • pale skin;

  • weakness on a side of the body;

  • severe headache, confusion, or dizziness;

  • easy bruising; or

  • a bleeding nose.

Other, less serious side effects may also occur. Continue to take ticlopidine and talk to your doctor if you experience

  • upset stomach, nausea, or vomiting;

  • ringing in the ears;

  • diarrhea;

  • dizziness; or

  • itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect ticlopidine?

Do not take ticlopidine without first talking to your doctor if you are taking any of the following medicines:
  • aspirin;

  • warfarin (Coumadin);

  • heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), or enoxaparin (Lovenox);

  • clopidogrel (Plavix);

  • dipyridamole (Persantine); or

  • a nonsteroidal anti-inflammatory medication such as ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Anaprox, Naprosyn, Aleve), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), diflunisal (Dolobid), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin).

The medicines listed above can cause bleeding, especially when taken with ticlopidine. This interaction could become dangerous.

Before taking ticlopidine, tell your doctor if you are taking

  • antacids or cimetidine (Tagamet, Tagamet HB);

  • digoxin (Lanoxin, Lanoxicaps);

  • theophylline (Theo-Dur, Theochron, Theolair, others); or

  • phenytoin (Dilantin).

You may require a dosage adjustment or special monitoring if you are taking any of the medications listed above.

Drugs other than those listed here may also interact with ticlopidine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has more information about ticlopidine written for health professionals that you may read.

What does my medication look like?

Ticlopidine is available with a prescription generically and under the brand name Ticlid. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Ticlid 250 mg--white, oval, film-coated tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.01. Revision Date: 9/22/04 3:34:30 PM.



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