Thiopental Sodium

drug-information.ru

|Thiopental Sodium

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Thiopental Sodium

Pronouncation: (thigh-oh-PEN-tahl SO-dee-uhm)
Class: Barbiturate

Trade Names:
Pentothal
- Powder for injection 2% (20 mg/mL)
- Powder for injection 2.5% (25 mg/mL)

Mechanism of Action

Pharmacology

Depresses CNS to produce hypnosis and anesthesia without analgesia.

Pharmacokinetics

Distribution

Thiopental is 80% bound to plasma proteins. The partition coefficient is 580.

Metabolism

Thiopental is degraded in liver and to a smaller extent, kidney and brain. The concentrations in spinal fluid is slightly less than in plasma.

Elimination

Thiopental is eliminated in urine and t ½ is 3 to 8 hr.

Indications and Usage

Induction of anesthesia; supplementation of other anesthetic agents; IV anesthesia for short surgical procedures with minimal painful stimuli; induction of hypnotic state; control of convulsions and increased intracranial pressure (IV administration); induction of preanesthetic sedation or basal narcosis (PR administration).

Contraindications

Hypersensitivity to barbiturates; variegate or acute intermittent porphyria; absence of suitable veins for IV administration; status asthmaticus.

Rectal administration

Patients undergoing rectal surgery; lesions of bowel.

Dosage and Administration

Test Dose
Adults

IV 25 to 75 mg; observe for 60 sec.

Anesthesia
Adults

IV 50 to 75 mg slowly q 20 to 40 sec until anesthesia is established then 25 to 50 mg prn or continuous infusion of 0.2% or 0.4%.

Children

IV 5 to 6 mg/kg then 1 mg/kg prn.

Infants

IV 5 to 8 mg/kg then 1 mg/kg prn.

Newborns

IV 3 to 4 mg/kg then 1 mg/kg prn.

Convulsive States
Adults

IV 75 to 125 mg; may need 125 to 250 mg over 10 min.

Children

IV 2 to 3 mg/kg/dose; repeat prn.

Increased Intracranial Pressure
Adults

IV 1.5 to 3.5 mg/kg.

Children

IV 1.5 to 5 mg/kg/dose; repeat prn.

Psychiatric Disorders
Adults

IV 100 mg/min slowly with patient counting backwards or as infusion of 50 mL/min of 0.2% solution.

Preanesthetic Sedation
Adults

PR 1 g/34 kg (30 mg/kg).

Basal Narcosis
Adults

PR 1 g/22.5 kg (44 mg/kg) (max, 3 to 4 g for adults weighing over 90 kg).

Children over 3 mo

PR 25 mg/kg/dose; if not sedated within 15 to 20 min, may repeat with single dose of 15 mg/kg/dose (max, 1.15 g for children over 34 kg).

Children under 3 mo

PR 15 mg/kg/dose; if not sedated within 15 to 20 min, may repeat with single dose of less than 7.5 mg/kg/dose.

Storage/Stability

Store at room temperature, protected from light.

Drug Interactions

Narcotics

May cause additive barbiturate effects and increase risk of apnea.

Phenothiazines

May increase frequency and severity of neuromuscular excitation and hypotension.

Probenecid

May extend barbiturate effects or effects may be achieved at lower doses.

Sulfisoxazole

May enhance barbiturate effects.

Incompatibility

Tubocurarine, succinylcholine, or other acid pH solutions.

Laboratory Test Interactions

LFTs

Drug may falsely elevate results.

Serum potassium

Drug may falsely elevate results.

Adverse Reactions

Cardiovascular

Myocardial depression; arrhythmias.

CNS

Delirium, headache; amnesia; seizures.

Dermatologic

Rash.

GI

Abdominal pain; rectal irritation; diarrhea; cramping; rectal bleeding (rectal suspension).

Respiratory

Apnea; laryngospasm; bronchospasm; hiccoughs; sneezing; coughing.

Miscellaneous

Thrombophlebitis; pain at injection site; salivation; shivering.

Precautions

Pregnancy

Category C ; readily crosses placental barrier.

Lactation

Excreted in breast milk.

Elderly

At increased risk of prolonged or potentiated hypnotic effects. Dosage reduction is required when administered rectally.

Renal Function

Use drug with caution in patients with renal disease. Dosage reduction is required (75% of normal dose if Ccr is less than 10 mL/min).

Hepatic Function

Use drug with caution in patients with hepatic disease.

Special Risk Patients

Use drug with caution in patients with severe cardiovascular, respiratory, renal, hepatic, or endocrine disease, hypotension or shock, conditions in which hypnotic effects may be prolonged or potentiated, potential rectal surgery (rectal suspension), or presence of inflammatory, ulcerative, bleeding, or neoplastic lesions of lower bowel (rectal suspension).

Repeated doses

May result in prolonged drug effect because of accumulation.

Overdosage

Symptoms

Respiratory depression, hypotension, shock, apnea, occasional laryngospasm, coughing, respiratory difficulties.

Patient Information

  • Instruct patient to notify health care provider of any signs of hypersensitivity to barbiturates.
  • Inform patient to avoid alcohol or other CNS depressants for 24 hr.
  • Advise patient that drug can continue to impair abilities for 24 hr following administration and caution patient to avoid driving or performing other tasks requiring mental alertness.




Where can I get more information about Thiopental Sodium ? We recommend to use www.Drugs.com

Typical mistypes for Thiopental Sodium
rhiopental sodium, fhiopental sodium, ghiopental sodium, yhiopental sodium, 6hiopental sodium, 5hiopental sodium, tgiopental sodium, tbiopental sodium, tniopental sodium, tjiopental sodium, tuiopental sodium, tyiopental sodium, thuopental sodium, thjopental sodium, thkopental sodium, thoopental sodium, th9opental sodium, th8opental sodium, thiipental sodium, thikpental sodium, thilpental sodium, thippental sodium, thi0pental sodium, thi9pental sodium, thiooental sodium, thiolental sodium, thio-ental sodium, thio0ental sodium, thiopwntal sodium, thiopsntal sodium, thiopdntal sodium, thioprntal sodium, thiop4ntal sodium, thiop3ntal sodium, thiopebtal sodium, thiopemtal sodium, thiopejtal sodium, thiopehtal sodium, thiopenral sodium, thiopenfal sodium, thiopengal sodium, thiopenyal sodium, thiopen6al sodium, thiopen5al sodium, thiopentzl sodium, thiopentsl sodium, thiopentwl sodium, thiopentql sodium, thiopentak sodium, thiopentap sodium, thiopentao sodium, thiopental aodium, thiopental zodium, thiopental xodium, thiopental dodium, thiopental eodium, thiopental wodium, thiopental sidium, thiopental skdium, thiopental sldium, thiopental spdium, thiopental s0dium, thiopental s9dium, thiopental sosium, thiopental soxium, thiopental socium, thiopental sofium, thiopental sorium, thiopental soeium, thiopental soduum, thiopental sodjum, thiopental sodkum, thiopental sodoum, thiopental sod9um, thiopental sod8um, thiopental sodiym, thiopental sodihm, thiopental sodijm, thiopental sodiim, thiopental sodi8m, thiopental sodi7m, thiopental sodiun, thiopental sodiuk, thiopental sodiuj, hiopental sodium, tiopental sodium, thopental sodium, thipental sodium, thioental sodium, thiopntal sodium, thiopetal sodium, thiopenal sodium, thiopentl sodium, thiopenta sodium, thiopentalsodium, thiopental odium, thiopental sdium, thiopental soium, thiopental sodum, thiopental sodim, thiopental sodiu, htiopental sodium, tihopental sodium, thoipental sodium, thipoental sodium, thioepntal sodium, thiopnetal sodium, thiopetnal sodium, thiopenatl sodium, thiopentla sodium, thiopenta lsodium, thiopentals odium, thiopental osdium, thiopental sdoium, thiopental soidum, thiopental soduim, thiopental sodimu, tthiopental sodium, thhiopental sodium, thiiopental sodium, thioopental sodium, thioppental sodium, thiopeental sodium, thiopenntal sodium, thiopenttal sodium, thiopentaal sodium, thiopentall sodium, thiopental sodium, thiopental ssodium, thiopental soodium, thiopental soddium, thiopental sodiium, thiopental sodiuum, thiopental sodiumm, etc.



© Copyright by drug-information.ru 2001-2019. All rights reserved