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BELLADONNA ALKALOIDS AND BARBITURATES (Systemic)
Some commonly used brand names are:
In the U.S.—
Belladonna alkaloids and barbiturates are combination medicines taken to relieve cramping and spasms of the stomach and intestines. They are used also to decrease the amount of acid formed in the stomach.
These medicines are available only with your doctor"s prescription in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For belladonna alkaloids and barbiturates, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to belladonna alkaloids (atropine, belladonna, hyoscyamine, and scopolamine) or to barbiturates (butabarbital, phenobarbital). Also, tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Belladonna alkaloids have not been shown to cause problems in humans. However, barbiturates (contained in this medicine) have been shown to increase the chance of birth defects in humans. Also, when taken during pregnancy, barbiturates may cause bleeding problems in the newborn baby. Be sure that you have discussed this with your doctor before taking this medicine.
Breast-feeding—Belladonna alkaloids or barbiturates have not been shown to cause problems in nursing babies. However, traces of the belladonna alkaloids and barbiturates pass into the breast milk. Also, because the belladonna alkaloids tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients.
Children—Severe side effects may be more likely to occur in infants and children, especially those with spastic paralysis or brain damage. Unusual excitement, nervousness, restlessness, or irritability and unusual warmth, dryness, and flushing of skin are more likely to occur in children, who are usually more sensitive to the effects of belladonna alkaloids. Also, when belladonna alkaloids are given to children during hot weather, a rapid increase in body temperature may occur. In addition, the barbiturate in this medicine could cause some children to become hyperactive.
Older adults—Confusion or memory loss; constipation; difficult urination; drowsiness; dryness of mouth, nose, throat, or skin; and unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of belladonna alkaloids and barbiturates. Also, eye pain may occur, which may be a sign of glaucoma.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking belladonna alkaloids and barbiturates, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of belladonna alkaloids and barbiturates. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Take this medicine about 1/2 to 1 hour before meals, unless otherwise directed by your doctor.
Take this medicine only as directed . Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
Dosing—The dose of belladonna alkaloids and barbiturates combination will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of these combination medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The number of capsules or tablets or the amount of solution you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking these combination products .
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine .
Do not take this medicine within 1 hour of taking antacids or medicine for diarrhea. Taking them too close together will make the belladonna alkaloids less effective.
Belladonna alkaloids will often make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine , as overheating could possibly result in heat stroke. This is especially important in children taking belladonna alkaloids.
This medicine may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort.
This medicine may cause some people to have blurred vision or to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see well .
This medicine may cause dryness of the mouth, nose, and throat. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Eye pain; skin rash or hives; sore throat and fever; unusual bleeding or bruising; yellow eyes or skin
Symptoms of overdose
Blurred vision (continuing) or changes in near vision; clumsiness or unsteadiness; confusion; convulsions (seizures); dizziness (continuing); drowsiness (severe); dryness of mouth, nose, or throat (severe); fast heartbeat; fever; hallucinations (seeing, hearing, or feeling things that are not there); shortness of breath or troubled breathing; slurred speech; unusual excitement, nervousness, restlessness, or irritability; unusual warmth, dryness, and flushing of skin
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Constipation; decreased sweating; dizziness; drowsiness; dryness of mouth, nose, throat, or skin
Less common or rare
Bloated feeling; blurred vision; decreased flow of breast milk; difficult urination; difficulty in swallowing; headache; increased sensitivity of eyes to sunlight; loss of memory; nausea or vomiting; unusual tiredness or weakness
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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