selegiline

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Eldepryl, Zelapar, |selegiline

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selegiline

Generic Name: selegiline (oral) (se LE ji leen)
Brand Names: Eldepryl, Zelapar

What is selegiline?

Selegiline prevents the breakdown of a chemical in your brain called dopamine (DO pa meen). Low levels of this chemical are associated with Parkinson"s disease.

Selegiline is used together with other medicines to treat symptoms of Parkinson"s disease.

Selegiline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about selegiline?

There are many other medicines that can cause serious medical problems if you take them together with selegiline. Tell your doctor about all other prescription and over-the-counter medications you use, including vitamins, minerals, and herbal products.

While taking selegiline, do not drink alcohol or eat foods that are high in tyramine, listed in the "What should I avoid while using selegiline?" section of this leaflet. Eating tyramine while you are using selegiline can raise your blood pressure to dangerous levels and cause life-threatening symptoms.

You should become very familiar with the list of foods to avoid while you are using selegiline.

Do not stop taking selegiline suddenly or you may have harmful side effects. Keep taking the medicine as prescribed. Talk with your doctor before stopping the medication.

What should I discuss with my healthcare provider before using selegiline?

Do not use this medication if you are allergic to selegiline, or if you have used any of the following drugs within the past 14 days:
  • cough or cold medicine that contains dextromethorphan;

  • meperidine (Demerol), propoxyphene (Darvon, Darvocet), or tramadol (Ultram, Ultracet);

  • methadone (Dolophine, Methadose); or

  • other MAO inhibitors such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or transdermal selegiline (Emsam).

After you stop taking selegiline, you must wait at least 14 days before taking any of the medications listed above.

Before using this medicine, tell your doctor if you have kidney disease, liver disease, heart disease, high or low blood pressure, or a seizure disorder. If you have any of these conditions, you may not be able to use selegiline, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether selegiline passes into breast milk or if it could harm a nursing baby. Do not take selegiline without telling your doctor if you are breast-feeding a baby.

The selegiline disintegrating tablets may contain phenylalanine. Talk to your doctor before using this form of selegiline if you have phenylketonuria (PKU).

How should I take selegiline?

Take selegiline exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Larger doses will not have any greater effect, but serious side effects could result. Follow the directions on your prescription label.

While you are using selegiline and for 14 days after you stop, you must not eat foods listed in the "What should I avoid while using selegiline?" section of this leaflet. Eating these foods while you are using selegiline can raise your blood pressure to dangerous levels.

Foods that you MAY eat include:

  • fresh meat, poultry, or fish (including lunch meat, hot dogs, breakfast sausage, and cooked sliced ham);

  • any vegetables except broad bean pods (fava beans);

  • processed cheese, mozzarella, ricotta, cottage cheese;

  • pizza made with cheeses low in tyramine;

  • soy milk, yogurt; or

  • Brewer"s or baker"s yeast.

Selegiline capsules are usually taken twice a day, at breakfast and lunch. Follow your doctor"s instructions. The disintegrating tablet form of selegiline (Zelapar) should be taken once a day before breakfast and without any liquid.

To take selegiline orally disintegrating tablets (Zelapar):

  • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

  • Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves.

  • Do not drink or eat anything for at least 5 minutes after taking a Zelapar orally disintegrating tablet.

Parkinson"s disease is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. When you start taking selegiline, your doses of the other medications may need to change. Do not change your doses or medication schedule without advice from your doctor.

Do not stop taking selegiline suddenly or you may have harmful side effects. For best results, keep taking the medicine as prescribed. Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a selegiline overdose may include severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions).

What should I avoid while using selegiline?

You must NOT eat foods that are high in tyramine, including:
  • air dried meats, aged or fermented meats, sausage or salami (including cacciatore and mortadella), pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver;

  • beer from a tap, beer that has not been pasteurized;

  • aged cheeses, including blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, parmesan, romano, roquefort, stilton, and swiss;

  • over-the-counter supplements or cough and cold medicines that contain tyramine;

  • sauerkraut, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans; or

  • yeast extracts (such as Marmite).

Eating tyramine while you are taking selegiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects.

You should become very familiar with the list of foods to avoid while you are taking selegiline.

Avoid drinking alcohol while taking selegiline. Selegiline can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Selegiline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking selegiline and call your doctor at once if you have any of these serious side effects:
  • sudden and severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, seizure (convulsions), and sudden numbness or weakness (especially on one side of the body);

  • feeling light-headed, fainting;

  • hallucinations;

  • feeling restless, agitated, or irritable;

  • twitching muscle movements; or

  • painful or difficult urination.

Continue taking selegiline and talk with your doctor if you have any of these less serious side effects:

  • dizziness, weakness;

  • sleep problems (insomnia);

  • runny or stuffy nose;

  • back pain;

  • constipation; or

  • mouth sores or ulcers, pain with swallowing (while using Zelapar).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect selegiline?

Before taking selegiline, tell your doctor if you are using any of the following drugs:

  • carbamazepine (Tegretol);

  • diet pills or cold medicines that contain ephedrine, pseudoephedrine, or phenylephrine;

  • nafcillin (Unipen);

  • phenobarbital (Luminal, Solfoton);

  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  • antidepressants such as amitriptyline (Elavil), amoxapine (Ascendin), bupropion (Wellbutrin, Zyban), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), venlafaxine (Effexor), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to take selegiline, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can cause serious medical problems if you take them together with selegiline. Do not take selegiline before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist has information about selegiline written for health professionals that you may read.

What does my medication look like?

Selegiline is available with a prescription under the brand names Eldepryl and Zelapar. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Eldepryl 5 mg--aqua-blue capsules

  • Zelapar 1.25 mg--pale yellow orally disintegrating tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.12. Revision Date: 03/07/2007 09:05:24.



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