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|Secobarbital Sodium |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Secobarbital SodiumPronouncation: (see-koe-BAR-bih-tahl SO-dee-uhm)Class: Sedative and hypnotic, Barbiturate Trade Names: Mechanism of ActionPharmacologyDepresses sensory cortex, decreases motor activity, alters cerebellar function, and produces drowsiness, sedation, and hypnosis. PharmacokineticsAbsorptionSecobarbital absorption is rapid; the rate is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach. DistributionSecobarbital has very high lipid solubility and high protein binding. The drug is distributed to all tissues and fluids, with high concentrations in the brain, liver, and kidneys. MetabolismMetabolism of secobarbital is primarily by the hepatic microsomal enzyme system. EliminationSecobarbital is eliminated renally. The inactive metabolites are excreted as conjugates of glucuronic acid. T ½ is 15 to 40 hr (mean, 28 hr). OnsetSecobarbital"s onset of action is 10 to 15 min (PO). DurationSecobarbital"s duration of action is 3 to 4 hr (PO). Indications and UsageShort-term (up to 2 wk) treatment of insomnia; induction of basal hypnosis before anesthesia (parenteral form); sedation (parenteral form). Unlabeled UsesControl of status epilepticus or acute seizure episodes. ContraindicationsHypersensitivity to barbiturates; history of addiction to sedative/hypnotic drugs; history of porphyria; severe liver impairment; respiratory disease with dyspnea; nephritic patients. Dosage and AdministrationInsomniaAdults PO At bedtime 100 mg. HypnoticAdults IM 100 to 200 mg; IV 50 to 250 mg. SedationAdults PO 30 to 50 mg tid or qid. ChildrenPO/PR 2 to 6 mg/kg. For rectal administration, dilute to 1% to 1.5% solution. Preoperative SedationAdults PO 200 to 300 mg 1 to 2 hr before surgery. ChildrenPO 2 to 6 mg/kg (max, 100 mg) 1 to 2 hr before surgery. Sedation/PreanesthesiaAdults IM (light sedation) 1 mg/kg 15 min before procedure. ChildrenIM 4 to 5 mg/kg. ConvulsionsAdults IM/IV 1.1 to 2.2 mg/kg. Maximum IV rate 50 mg/15 sec. Maximum adult IM dose 500 mg or 5 mL volume regardless of concentration. Storage/StabilityStore oral preparation at room temperature. Refrigerate parenteral form. Use only clear solution; discard if precipitate forms or solution becomes cloudy. Drug InteractionsAlcohol, CNS depressantsMay produce additive CNS depressant effects. Anticoagulants (eg, warfarin), beta blockers (eg, metoprolol, propranolol), verapamil, quinidine, theophyllinesMay reduce activity of these drugs. AnticonvulsantsMay reduce serum concentrations of carbamazepine, valproic acid, and succinimides. Valproic acid may increase barbiturate serum levels. CorticosteroidsMay reduce effectiveness of corticosteroids. Estrogens, estrogen-containing oral contraceptivesMay reduce contraceptive effect and estrogen effect. Laboratory Test InteractionsMay increase bromsulphalein retention; may cause decreased serum bilirubin concentrations; false-positive phentolamine test results; decreased response to metyrapone; impaired absorption of radioactive cyanocobalamin. Adverse ReactionsCardiovascularBradycardia; hypotension; syncope. CNSDrowsiness; agitation; confusion; headache; hyperkinesia; ataxia; CNS depression; paradoxical excitement; nightmares; psychiatric disturbances; hallucinations; insomnia; dizziness. GINausea; vomiting; constipation. HematologicBlood dyscrasias (eg, agranulocytosis, thrombocytopenia). RespiratoryHypoventilation; apnea; laryngospasm; bronchospasm. MiscellaneousHypersensitivity reactions (eg, angioedema, rashes, exfoliative dermatitis); fever; liver damage; injection site reactions (eg, local pain, thrombophlebitis). Precautions
PregnancyCategory D . LactationExcreted in breast milk. ChildrenMay respond with excitement rather than depression. ElderlyMore sensitive to drug effects; dosage reduction is required. Renal FunctionUse drug with caution; dosage reduction may be required. Hepatic FunctionUse drug with caution; dosage reduction may be required. DependenceTolerance or psychological and physical dependence may occur with continued use. IV administrationDo not exceed maximum IV rate 50 mg/15 sec; respiratory depression, apnea, and hypotension may result. Parenteral solutions are highly alkaline; extravasation may cause tissue damage and necrosis. Inadvertent intra-arterial injection may lead to arterial spasm, thrombosis and gangrene. Seizure disordersStatus epilepticus may result from abrupt discontinuation. OverdosageSymptomsCNS and respiratory depression, Cheyne-Stokes respiration, areflexia, oliguria, tachycardia, hypotension, lowered body temperature, coma, pulmonary edema, death. Patient Information
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