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GROWTH HORMONE (Systemic)
Some commonly used brand names are:
In the U.S.—
Somatrem and somatropin are man-made versions of human growth hormone. Growth hormone is naturally produced by the pituitary gland and is necessary to stimulate growth in children. Man-made growth hormone may be used in children who have certain conditions that cause failure to grow normally. These conditions include growth hormone deficiency (inability to produce enough growth hormone), kidney disease, Prader-Willi Syndrome (PWS), and Turner"s syndrome. Growth hormone is also used in adults to treat growth failure and to treat weight loss caused by acquired immunodeficiency syndrome (AIDS).
This medicine is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For growth hormone, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to growth hormone. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives (especially benzyl alcohol), or dyes.
Pregnancy—Growth hormone has not been studied in pregnant women. However, in animal studies, growth hormone has not been shown to cause birth defects or other problems. This drug should be used during pregnancy only if clearly needed. Tell your doctor if you are pregnant or plan on becoming pregnant.
Breast-feeding—It is not known whether growth hormone passes into breast milk. However, you should tell your doctor if you are nursing.
Children—There is no specific information comparing use of growth hormone in children with acquired immunodeficiency syndrome (AIDS) with use in other age groups.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of growth hormone in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults. However, elderly patients may be more sensitive to the action of growth hormone drugs and may be more at risk to develop adverse reactions.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking growth hormone, it is especially important that your health care professional know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of growth hormone. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Some medicines given by injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your health care professional will teach you how to prepare and inject the medicine. You will have a chance to practice preparing and injecting it. Be certain that you understand exactly how the medicine is to be prepared and injected .
It is important to read the patient information and instructions for use, if provided with your medicine, each time your prescription is filled.
It is important to follow any instructions from your doctor about the careful selection and rotation of injection sites on your body . This will help to prevent skin problems.
Put used needles and syringes in a puncture-resistant disposable container or dispose of them as directed by your health care professional. Do not reuse needles and syringes .
Dosing—The dose of these medicines will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
Storage—To store this medicine:
Precautions While Using This Medicine
It is important that your doctor check your progress at regular visits .
Side Effects of This Medicine
Leukemia has been reported in a few patients after treatment with growth hormone. However, it is not definitely known whether the leukemia was caused by the growth hormone. Leukemia has also been reported in patients whose bodies do not make enough growth hormone and who have not yet been treated with man-made growth hormone. However, discuss this possible effect with your doctor.
If growth hormone is given to children or adults with normal growth, who do not need growth hormone, serious unwanted effects may occur because levels in the body become too high. These effects include the development of diabetes; abnormal growth of bones and internal organs such as the heart, kidneys, and liver; atherosclerosis (hardening of the arteries); and hypertension (high blood pressure).
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur:
Abnormal or decreased touch sensation; blurred vision; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; dizziness; ear infection or other ear problems (in patients with Turner"s syndrome); nervousness; pounding in the ears; severe headache; slow or fast heartbeat
Abdominal pain or bloating; changes in vision; depression of skin at place of injection; headache; limp; nausea and vomiting; pain and swelling at place of injection; pain in hip or knee; skin rash or itching
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Back pain; chills; cough or cough producing mucus; constipation; depressed mood; diarrhea; difficulty in breathing; difficulty in moving; dizziness; dry skin and hair; ear congestion; feeling cold; fever; general feeling of discomfort or illness; hair loss; hoarseness or husky voice; loss of appetite; loss of voice; runny nose; shivering; shortness of breath; sore throat; slowed heartbeat; sneezing; stuffy nose; sweating; swollen joints; tightness in chest; trouble sleeping; weight gain; wheezing
Less common or rare
Carpal tunnel syndrome; discouragement; enlargement of breasts; feeling sad or empty; increased growth of birthmarks; irritability; joint pain; loss of interest or pleasure; muscle pain, cramps, or stiffness; skeletal pain; sleepiness; swelling of hands, feet, or lower legs; trouble concentrating; unable to sleep; unusual tiredness or weakness
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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