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|Rosiglitazone maleate Rosiglitazone Maleate

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Rosiglitazone maleate

Generic name: Rosiglitazone maleate
Brand names: Avandia

Why is Rosiglitazone maleate prescribed?

Rosiglitazone maleate is used to hold down blood sugar levels in people with type 2 diabetes (also known as "non-insulin dependent" or "adult onset" diabetes).

Blood sugar levels are ordinarily controlled by the body"s natural supply of insulin, which helps sugar move out of the bloodstream and into the cells. In type 2 diabetes, the buildup of sugar in the blood is often due not to a lack of insulin, but to the body"s inability to make proper use of it. Rosiglitazone maleate works first by decreasing sugar production, then by helping the body make more efficient use of whatever insulin is available. It does not increase the actual amount of insulin in circulation.

Rosiglitazone maleate is a new type of diabetes medication. It can be used alone or in conjunction with insulin, metformin (Glucophage), or a member of the sulfonylurea class of diabetes drugs (Diabinese, Micronase, Orinase). It takes effect slowly. You may not see a reduction in blood sugar levels for the first 2 weeks of therapy, and it may take 2 to 3 months for the medication to deliver maximum results.

Most important fact about Rosiglitazone maleate

Always remember that Rosiglitazone maleate is an aid to, not a substitute for, good diet, weight loss, and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications, such as dangerously high or low blood sugar levels. Remember, too, that Rosiglitazone maleate is not an oral form of insulin, and cannot be used in place of insulin.

How should you take Rosiglitazone maleate?

Your dose of Rosiglitazone maleate may be taken once a day in the morning or divided in half and taken in the morning and evening, with or without food.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature in a tight, light-resistant container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Rosiglitazone maleate.

More common side effects may include:
Back pain, fatigue, headache, high blood sugar, low blood sugar, respiratory tract infections, sinus inflammation, swelling

Why should Rosiglitazone maleate not be prescribed?

Do not take Rosiglitazone maleate if it has ever given you an allergic reaction.

Special warnings about Rosiglitazone maleate

If you have liver disease, you should not take Rosiglitazone maleate. Your doctor will check to make sure your liver function is normal before prescribing Rosiglitazone maleate, then recheck it every 2 months for the first 12 months and periodically thereafter. Warning signs of liver damage include nausea, vomiting, abdominal pain, fatigue, loss of appetite, and dark urine. If you develop any of these symptoms, tell your doctor immediately. You may need to discontinue treatment with Rosiglitazone maleate.

People taking Rosiglitazone maleate in combination with insulin or other diabetes drugs sometimes develop low blood sugar. If this happens, check with your doctor. The dosage of the other diabetes drug may have to be reduced.

People with kidney problems can take Rosiglitazone maleate, but should not take Glucophage. If you have poor kidney function, you"ll be unable to take advantage of this combination.

Rosiglitazone maleate can increase the chances of conception. Be sure to use some form of birth control if you don"t want a pregnancy.

Rosiglitazone maleate won"t help type 1 diabetics, who are unable to produce any insulin at all. Insulin shots are a necessity for this form of the illness. Nor can Rosiglitazone maleate relieve diabetic ketoacidosis (excessively high sugar levels due to lack of insulin).

Use Rosiglitazone maleate with caution if you have a problem with fluid retention or swelling. The drug has been known to cause this problem, which in turn can lead to heart failure or other heart problems. Rosiglitazone maleate should be avoided by anyone who has been diagnosed with heart failure, and it should be discontinued by anyone who develops it. Make sure the doctor is aware of any heart problems you may have. Alert him immediately if you develop symptoms of heart failure such as fatigue and shortness of breath.

If you are being treated with Rosiglitazone maleate and insulin you will need to be monitored for heart problems. Notify your doctor if you develop any unusual swelling or a rapid weight increase.

You should be aware that people taking Rosiglitazone maleate tend to gain a little weight, typically around 5 to 10 pounds. The cause is thought to be a combination of fluid retention and fat accumulation.

Rosiglitazone maleate is not recommended for children under 18.

Possible food and drug interactions when taking Rosiglitazone maleate

No drug interactions with Rosiglitazone maleate have been reported at this time.

Special information if you are pregnant or breastfeeding

It"s important to maintain normal blood sugar levels while pregnant, but the safety of Rosiglitazone maleate during pregnancy remains unproven. Since insulin shots are known to be safe, your doctor may switch you from Rosiglitazone maleate to insulin until the baby is born.

It is not known whether Rosiglitazone maleate appears in breast milk. Because many drugs do find their way into breast milk, however, the safest bet is to avoid taking Rosiglitazone maleate while nursing.

Recommended dosage

ADULTS

The usual starting dose of Rosiglitazone maleate either alone or in combination with insulin or another diabetes drug is 4 milligrams once a day or 2 milligrams twice a day. If your sugar levels remain too high after 12 weeks of treatment, the doctor may increase your dose to 8 milligrams once a day or 4 milligrams twice a day. However, the maximum recommended dose of Rosiglitazone maleate in combination with insulin or a sulfonylurea diabetes drug is 4 milligrams per day. If you do develop low blood sugar, your insulin or sulfonylurea drug dosage will need to be decreased by your doctor.

Overdosage

Although there is no information on the potential results of Rosiglitazone maleate overdose, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

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