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|Ropinirole hydrochloride Ropinirole Hydrochloride

Ropinirole hydrochloride

Generic name: Ropinirole hydrochloride
Brand names: Requip

Why is Ropinirole hydrochloride prescribed?

Ropinirole hydrochloride helps relieve the signs and symptoms of Parkinson"s disease. Caused by a deficit of dopamine (one of the brain"s chief chemical messengers), this disorder is marked by progressive muscle stiffness, tremor, and fatigue. Ropinirole hydrochloride works by stimulating dopamine receptors in the brain, thus promoting better, easier movement.

Ropinirole hydrochloride can be taken with or without levodopa (usually prescribed as Sinemet), another drug used to treat the symptoms of Parkinson"s disease.

Most important fact about Ropinirole hydrochloride

Ropinirole hydrochloride is not a cure for Parkinson"s disease. However, it does alleviate symptoms of the disease, and it can shorten the "off" periods of immobility that patients on long-term levodopa therapy often begin to experience.

How should you take Ropinirole hydrochloride?

Take 3 doses a day, with or without food. If the drug upsets your stomach, combining it with food may relieve the problem. If you are also taking levodopa, its dosage may be gradually decreased when you start therapy with Ropinirole hydrochloride.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature away from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Ropinirole hydrochloride.

• More common side effects may include:
  Abdominal pain, abnormal dreaming, abnormal muscle movements, abnormal vision, amnesia, anxiety, arthritis, bronchitis, confusion, constipation, decreased muscle movements, diarrhea, difficulty breathing, dizziness, drowsiness, dry mouth, eye problems, fainting, falling, fatigue, hallucinations, headache, increased sweating, indigestion, joint pain, leg swelling, nausea, nervousness, pain, paralysis, respiratory tract infection, runny nose, sinus inflammation, skin tingling, sore throat, swelling, tremor, urinary tract infection, viral infections, vomiting, weakness

Why should Ropinirole hydrochloride not be prescribed?

If Ropinirole hydrochloride gives you an allergic reaction, you will not be able to continue using it.

Special warnings about Ropinirole hydrochloride

At the start of Ropinirole hydrochloride therapy and whenever the dose is increased, you face a slightly increased risk of a fainting spell or other symptoms of low blood pressure such as dizziness, nausea, sweating, and light-headedness, particularly when you get up suddenly after sitting or reclining for a prolonged period. To avoid such symptoms, be careful to stand up slowly.

A few patients--especially older ones--also develop hallucinations. Let your doctor know if this occurs. You may have to stop Ropinirole hydrochloride therapy.

Use Ropinirole hydrochloride with caution if you have heart disease. There is also a slight chance of developing respiratory difficulties or problems with your eyesight. If you find it hard to breathe, have any swelling, or develop problems with your vision, alert your doctor at once.

If you are taking Sinemet with Ropinirole hydrochloride, you may experience jerking muscle movements. Tell your doctor. He will need to decrease your dose of Sinemet.

With other Parkinson"s medications, a sudden dose reduction has been known to cause high fever, muscle stiffness, and loss of consciousness. Although this has not happened with Ropinirole hydrochloride, be alert for such problems and contact your doctor immediately if they occur.

Ropinirole hydrochloride may cause drowsiness, and some people have reported falling asleep without warning during their daily activities. Do not drive a car or operate machinery until you know how the drug affects you. If you find that Ropinirole hydrochloride makes you sleepy or that you"re suddenly falling asleep in the middle of routine activities, tell your doctor; he will probably discontinue the drug.

Ropinirole hydrochloride may also cause darkening of your skin and eye color. Tell your doctor if you notice any change.

Possible food and drug interactions when taking Ropinirole hydrochloride

If Ropinirole hydrochloride is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important to check with your doctor before combining Ropinirole hydrochloride with the following:

Alcohol
Antidepressants such as Elavil, Pamelor, and Tofranil
Ciprofloxacin (Cipro)
Drugs that contain levodopa such as Dopar, Larodopa, and Sinemet
Estrogen medications such as ethinyl estradiol (Estinyl)
Major tranquilizers such as Haldol, Mellaril, Navane, Prolixin, and Thorazine
Metoclopramide (Reglan)
Tranquilizers such as the benzodiazepines Ativan, Librium, Valium, and Xanax

Special information if you are pregnant or breastfeeding

Although the effects of Ropinirole hydrochloride during pregnancy have not been adequately studied in humans, birth defects have occurred in animals. If you are pregnant or plan to become pregnant, inform your doctor immediately.

Ropinirole hydrochloride may inhibit production of breast milk. There is also a possibility that it will appear in breast milk and affect the nursing infant. If Ropinirole hydrochloride is essential to your health, your doctor may advise you to discontinue breastfeeding.

Recommended dosage

ADULTS

Ropinirole hydrochloride is taken 3 times a day. During the first week of therapy, each dose is 0.25 milligram. During the second week, the amount rises to 0.5 milligram. In the third week, it increases to 0.75 milligram, and in the fourth week reaches 1 milligram (3 milligrams daily). If necessary, your doctor will gradually increase the dosage further, up to a maximum of 24 milligrams per day.

If you need to stop Ropinirole hydrochloride therapy, the doctor will discontinue the drug gradually over a 7-day period, reducing the number of doses from 3 to 2 per day for the first 4 days, then to once a day for the remaining 3 days.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

• Symptoms of Ropinirole hydrochloride overdose may include:
  Agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness) upon standing, nausea, vomiting