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Rizatriptan benzoate

Generic name: Rizatriptan benzoate
Brand names: Maxalt-MLT, Maxalt

Why is Rizatriptan benzoate prescribed?

Rizatriptan benzoate is prescribed for the treatment of a migraine attack with or without the presence of an aura (visual disturbances, usually sensations of halos or flickering lights, which precede an attack). It cuts headaches short, but won"t prevent attacks.

Most important fact about Rizatriptan benzoate

Rizatriptan benzoate should be used only for typical migraine headaches. It is not recommended for any other type of headache, or for unusual types of migraine such as hemiplegic or basilar migraine.

How should you take Rizatriptan benzoate?

Take Rizatriptan benzoate as soon as your first symptoms appear. The drug is available in standard and orally disintegrating tablets (Rizatriptan benzoate-MLT). The standard tablets should be swallowed whole with liquid. No liquid is needed for Rizatriptan benzoate-MLT.

When using Rizatriptan benzoate-MLT, leave each individual blister pack in its foil pouch until needed. When ready, remove the pack from the pouch, peel it open with dry hands, and place the tablet on your tongue. The tablet will dissolve rapidly and can be swallowed with your saliva alone.

If your headache comes back, you may take a second dose as soon as 2 hours have elapsed. If the first dose provides no relief at all, check with your doctor before taking another.

Do not take more than 30 milligrams of Rizatriptan benzoate in a 24-hour period. Check with your doctor if you need to take the drug more than 4 times a month.

--If you miss a dose...

Rizatriptan benzoate is not for regular use. Take it only during a migraine attack.

--Storage instructions...

Rizatriptan benzoate and Rizatriptan benzoate-MLT may be stored at room temperature. Keep the Rizatriptan benzoate bottle tightly closed. Leave each Rizatriptan benzoate-MLT tablet in its pouch.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Rizatriptan benzoate.

More common side effects may include:
Chest pain, dizziness, drowsiness, dry mouth, fatigue, nausea, pain, tingling skin, weakness

Why should Rizatriptan benzoate not be prescribed?

If Rizatriptan benzoate gives you an allergic reaction, you won"t be able to use it. You should also avoid Rizatriptan benzoate if you have certain types of heart or blood vessel disease, including angina (crushing chest pain) or a history of heart attack. Do not use it if you have uncontrolled high blood pressure.

Never take Rizatriptan benzoate within 24 hours of using an ergotamine-type migraine medication such as Cafergot, D.H.E. 45 Injection, Migranal Nasal Spray, or Sansert, or a drug in the same family as Rizatriptan benzoate, such as Amerge, Imitrex, or Zomig. You should also refrain from using Rizatriptan benzoate within 2 weeks of taking an MAO inhibitor such as the antidepressants Marplan, Nardil, and Parnate.

Special warnings about Rizatriptan benzoate

Because some people with risk factors for heart and blood vessel disease have suffered an irregular heartbeat, a heart attack, or stroke after taking Rizatriptan benzoate, your doctor may ask you to take the first dose in the office, where you can be monitored for cardiac side effects. High blood pressure, high cholesterol, diabetes, smoking, a history of heart disease in your family, and menopause all increase the odds of such side effects.

Rizatriptan benzoate can cause drowsiness and dizziness. Do not participate in any activities that require full alertness until you are certain of the drug"s effect. Use Rizatriptan benzoate with caution if you have liver disease or need kidney dialysis. Also alert your doctor if you have an eye condition. There is a theoretical possibility that Rizatriptan benzoate could affect the eyes.

If your first dose of Rizatriptan benzoate has no effect on your symptoms, you may not be suffering from migraine. Ask your doctor for a re-evaluation.

If you have a condition called phenylketonuria, you should be aware that the Rizatriptan benzoate-MLT tablets contain phenylalanine.

Rizatriptan benzoate is not recommended for people under 18.

Possible food and drug interactions when taking Rizatriptan benzoate

The following drugs may boost or add to the effect of Rizatriptan benzoate and should never be combined with it:

Drugs classified as MAO inhibitors, including the antidepressants Marplan, Nardil, and Parnate
Ergot-containing drugs such as Cafergot, D.H.E. Injection, and Migranal Nasal Spray
Other drugs in the Rizatriptan benzoate family, including Amerge, Imitrex, and Zomig

Certain other drugs may also interact with Rizatriptan benzoate. Check with your doctor before combining it with the following:

Fluoxetine (Prozac)
Fluvoxamine (Luvox)
Paroxetine (Paxil)
Propranolol (Inderal)
Sertraline (Zoloft)

Special information if you are pregnant or breastfeeding

The effects of Rizatriptan benzoate during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. It is not known whether Rizatriptan benzoate appears in breast milk, but because many drugs do, you should use Rizatriptan benzoate with caution while nursing an infant.

Recommended dosage

ADULTS

The usual dose of Rizatriptan benzoate and Rizatriptan benzoate-MLT is one 5- or 10-milligram tablet. Doses should be spaced at least 2 hours apart. Take no more than 30 milligrams a day.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

Symptoms of Rizatriptan benzoate overdose may include:
Dizziness, fainting, heart and blood vessel problems, high blood pressure, loss of bowel and bladder control, slow heartbeat, vomiting

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