Rituxan

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Rituxan


Generic Name: Rituximab (ri-TUX-i-mab)
Brand Name: Rituxan

Severe and sometimes fatal lung problems, heart problems, and shock may occur with Rituxan . These problems often develop within 24 hours after the first dose of Rituxan . However, they may also occur at other times during treatment. Severe and sometimes fatal kidney problems and skin reactions may also occur during treatment with Rituxan . Tell your doctor right away if you experience chest pain; wheezing, shortness of breath, or trouble breathing; decreased urination; irregular heartbeat; red, swollen, peeling, or blistered skin; skin ulcers; hives; swelling of the mouth, face, lips or tongue; severe drowsiness; blurred vision; or any other unusual effects.


Rituxan is used for:

Treating patients who have certain types of non-Hodgkin lymphoma. It may used alone or in combination with other medicines. It is also used along with another medicine (methotrexate) to treat certain patients who have rheumatoid arthritis. It may also be used for other conditions as determined by your doctor.

Rituxan is a monoclonal antibody. It works to lower the number of certain types of white blood cells (B cells) in the body. This helps to treat the non-Hodgkin lymphoma. This also helps to decrease pain, swelling, and inflammation in certain patients with rheumatoid arthritis.

Do NOT use Rituxan if:

  • you are allergic to any ingredient in Rituxan or to mouse or rat protein
  • you have rheumatoid arthritis unless you have used other medicines first (eg, tumor necrosis factor [TNF] antagonists) and they did not work well
  • you have active hepatitis B infection

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rituxan :

Some medical conditions may interact with Rituxan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have symptoms of an infection (eg, fever, chills, persistent sore throat) or if you have a history of frequent infections
  • if you have a history of hepatitis B, hepatitis C, or other viral infections (eg, cytomegalovirus, herpes, JC virus, parvovirus, chickenpox, shingles, West Nile virus)
  • if you have a history of kidney, liver, lung, or heart problems (eg, irregular heartbeat, chest pain); bowel problems; or electrolyte problems
  • if you take medicine for high blood pressure or are scheduled to have surgery

Some MEDICINES MAY INTERACT with Rituxan . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cisplatin because serious kidney toxicity or kidney failure may occur
  • Medicines for high blood pressure because they may increase the risk of low blood pressure when you receive Rituxan

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rituxan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rituxan :

Use Rituxan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Rituxan . Talk to your pharmacist if you have questions about this information.
  • If you take medicine for high blood pressure, ask your doctor how to take it with Rituxan .
  • Rituxan is usually given as an injection at your doctor"s office, hospital, or clinic.
  • Do not use Rituxan if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Rituxan , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Rituxan .

Important safety information:

  • Rituxan may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Rituxan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Rituxan may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • The risk of certain viral infections may be greater while you use Rituxan and for up to 1 year after you stop using it. Certain viral infections may be very severe or fatal (eg, JC virus). Tell your doctor right away if you notice any symptoms of infection, especially if symptoms include confusion or disorientation, changes in vision, unusual eye movements, trouble walking or talking, or loss of balance or coordination.
  • Serious liver problems may develop in patients who have hepatitis B infection or who carry the hepatitis B virus and use Rituxan . Tell your doctor right away if you develop signs of liver problems, including dark urine, pale stools, severe stomach pain, or yellowing of the eyes or skin.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Rituxan . Talk with your doctor before you receive any vaccine.
  • Rituxan may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Rituxan before you receive any medical or dental care, emergency care, or surgery.
  • If you may become pregnant, you must use an effective form of birth control while you use Rituxan . You will need to continue to use birth control for 12 months after you stop Rituxan . If you have questions about effective birth control, talk with your doctor.
  • Lab tests, including kidney and liver function, complete blood cell counts, and blood electrolytes, may be performed while you use Rituxan and for several months after you stop using it. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Rituxan with caution in the ELDERLY; they may be more sensitive to its effects, especially irregular heartbeat, breathing problems, and lung infection.
  • Rituxan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Rituxan can cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rituxan while you are pregnant. It is not known if Rituxan is found in breast milk. Do not breast-feed while taking Rituxan .

Possible side effects of Rituxan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; flushing; headache; indigestion; lightheadedness; mild fever and chills, especially with the first dose; mild muscle or joint pain; nausea; night sweats; runny nose; throat irritation; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased amount of urine or dark urine; fainting; fast or irregular heartbeat; numbness of an arm or leg; persistent muscle, back, or joint pain; red, swollen, peeling, or blistered skin; severe or persistent dizziness; severe or persistent fever, chills, cough, or sore throat; severe stomach pain; severe weakness or fatigue; skin sores or ulcers; sudden leg pain or shortness of breath; sudden severe headache; swelling of the hands, legs, or feet; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Rituxan :

Rituxan is usually handled and stored by a health care provider. If you are using Rituxan at home, store Rituxan as directed by your pharmacist or health care provider. Do not freeze or shake Rituxan . Keep Rituxan out of the reach of children and away from pets.

General information:

  • If you have any questions about Rituxan , please talk with your doctor, pharmacist, or other health care provider.
  • Rituxan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rituxan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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