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|Rifampin

Rifampin

Rifampin is used for:

The treatment of all forms of tuberculosis and the treatment of some people who have meningitis without symptoms. It may also be used for other conditions as determined by your doctor.

Rifampin is an antituberculosis agent. It works by killing or stopping the growth of tuberculosis bacteria.

Do NOT use Rifampin if:

• you are allergic to any ingredient in Rifampin or to any rifamycin (eg, rifabutin)
• you have porphyria
• you are taking HIV protease inhibitors (eg, ritonavir) or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rifampin :

Some medical conditions may interact with Rifampin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are alcohol dependent or have alcohol withdrawal syndrome
• if you have jaundice, cirrhosis, other liver disease, or inflammation or obstruction of the bile ducts
• if you have had abnormal liver function tests
• if you have the blood disease porphyria or intestinal problems (eg, pseudomembranous colitis)

Some MEDICINES MAY INTERACT with Rifampin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many prescription and nonprescription medicines (eg, used for infections, blood thinners, high cholesterol, birth control, heart problems, HIV protease inhibitors (eg, ritonavir) and other medicines for HIV infection, mental or mood problems, seizures, diabetes) and herbs found in multivitamin products, herbal teas, dietary supplements (eg, garlic, St. John"s wort), and voriconazole may interact with Rifampin and may increase the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rifampin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rifampin :

Use Rifampin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Rifampin is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Rifampin at home, carefully follow the injection procedures taught to you by your health care provider.
• If Rifampin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• To clear up your infection completely, continue using Rifampin for the full course of treatment even if you feel better in a few days
• Rifampin works best if it is taken at the same time every day.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Rifampin , take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rifampin .

Important safety information:

• Rifampin may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Rifampin .
• Using Rifampin alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Rifampin is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
• It is important to use Rifampin for the full course of treatment. Failure to do so may decrease the effectiveness of Rifampin and increase the risk that the bacteria will no longer be sensitive to Rifampin and will not be able to be treated by this or certain other antibiotics in the future.
• Rifampin may produce a reddish coloration of your urine, sweat, saliva, and tears. Rifampin may also permanently stain soft contact lenses.
• Additional monitoring of your dose or condition might be necessary if you are taking isoniazid or itraconazole.
• Rifampin may interfere with certain lab tests. make sure your doctor and laboratory personnel know you are using Rifampin .
• Rifampin may decrease the effectiveness of hormonal contraceptives. If you are using birth control pills, it is recommended that you use an additional form of birth control while taking Rifampin .
• LAB TESTS, such as complete blood counts and liver function tests, may be needed to monitor your condition.
• Use Rifampin with caution in the ELDERLY because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Rifampin during pregnancy. Rifampin is excreted in breast milk. Do not breast-feed while taking Rifampin .

Possible side effects of Rifampin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cramps; diarrhea; dizziness; drowsiness; gas; headache; heartburn; menstrual changes; stomach pain or bloating.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fever, chills, or persistent sore throat; general feeling of discomfort; joint pain or swelling; loss of appetite; mental or mood changes; nausea or vomiting; pain, swelling, or redness at the injection site; red, swollen, or blistered skin; severe stomach pain; unusual bruising or bleeding; vision changes; wheezing; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include abdominal pain; increasing lethargy; itching; nausea; severe headache; swelling of the face; vomiting. Unconsciousness may occur in severe liver disease. Liver enlargement and yellowing of eyes and skin may develop rapidly. Lowered blood pressure, heart abnormalities, and seizures may develop.

Rifampin is usually handled and stored by a health care provider. If you are using Rifampin at home, store Rifampin as directed by your pharmacist or health care provider. Keep Rifampin out of the reach of children and away from pets.

General information:

• If you have any questions about Rifampin , please talk with your doctor, pharmacist, or other health care provider.
• Rifampin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.
• If using Rifampin for an extended period of time, obtain refills before your supply runs out.

This information is a summary only. It does not contain all information about Rifampin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.