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ProQuad, |ProQuad ProQuin XR

ProQuad

Generic Name: measles, mumps, rubella and varicella virus vaccine (MEE zulls, MUMPS, rue BEH la, and vare ih SELL ah vy rus vack seen)
Brand Names: ProQuad

What are measles, mumps, rubella and varicella virus vaccine?

Measles, mumps, rubella and varicella are serious diseases caused by viruses. They are spread from person to person through the air. Vaccines for these diseases expose the individual to a small amount of the virus (or to a protein from the virus) and cause the body to develop immunity to the disease.

Measles virus causes a rash, cough, runny nose, eye irritation, and fever. It can lead to ear infection, pneumonia, seizures (jerking and staring), brain damage, and death.

Mumps virus causes fever, headche, and swollen glands. It can lead to deafness, meningitis (infection of the brain and spinal cord covering), painful swelling of the testicles or ovaries, and rarely, death.

Rubella (German Measles) virus causes rash, mild fever, and arthritis (mostly in women). If a woman gets rubella while she is pregnant , she could have a miscarriage or her baby could be born with serious birth defects.

Chickenpox is a common childhood disease caused by the varicella virus. It is usually mild, but it can be serious, especially in young infants and adults. Varicella virus can be spread from person to person through the air, or by contact with fluid from chickenpox blisters. The chickenpox vaccine exposes the individual to a small amount of the virus (or to a protein from the virus) and causes the body to develop immunity to the disease. Most people who get chickenpox vaccine will not get chickenpox. But if someone who has been vaccinated does get chickenpox, it is usually very mild. They will have fewer spots, are less likely to have a fever, and will recover faster.

Chickenpox infection can cause rash, itching, fever, and tiredness. It can lead to severe skin infection, scars, pneumonia, brain damage, or death. A person who has had chickenpox can get a painful rash called shingles years later. About 12, 000 people are hospitalized for chickenpox each year in the United States. About 100 people die each year in the United States as a result of chickenpox.

Measles, mumps, rubella, and varicella vaccine can help prevent these diseases. Most people who are vaccinated will not get these diseases. Many more people would get these diseases if vaccination did not occur.

What is the most important information I should know about measles, mumps, rubella and varicella virus vaccine?

If you have a minor illnesses, such as a cold, you can still receive the vaccine. If you are moderately or severely ill, it is generally recommended that you wait until you have recovered before getting the vaccine.

Do not use salicylates (aspirin or aspirin containing products) for at least six weeks after receiving the vaccine. A serious condition called Reye"s Syndrome has been reported in patients with chicken pox taking salicylates.

What should I discuss with my healthcare provider before receiving measles, mumps, rubella and varicella virus vaccine?

• gelatin;

• eggs;

• the antibiotic neomycin; or

• a previous dose of measles, mumps and rubella (MMR) vaccine or varicella (chicken pox) vaccine.

Before receiving the vaccine, talk to your doctor if you

• have HIV or AIDS or another disease that affects the immune system;

• are taking a medication that affects the immune system (e.g. steroids, anti-rejection medications);

• have cancer;

• have a fever;

• have active untreated tuberculosis;

• are receiving cancer treatment with x-rays, radiation, or medication;

• have ever had a low platelet count (a blood disorder); or

• have recently had a blood transfusion or been given other blood products.

You may not be able to receive the vaccine at this time or you may require special monitoring.

Do not use salicylates (aspirin or aspirin containing products) for at least six weeks after receiving the vaccine. A serious condition called Reye"s Syndrome has been reported in patients with chicken pox taking salicylates.

If you have a minor illnesses, such as a cold, you can still receive the vaccine. If you are moderately or severely ill, it is generally recommended that you wait until you have recovered before getting a vaccine.

How are measles, mumps, rubella and varicella virus vaccine administered?

Your doctor, nurse, or other healthcare provider will administer measles, mumps, rubella, and varicella vaccine as an injection.

What happens if I miss a dose?

Contact your doctor if you think you have missed a dose of measles, mumps, rubella, and varicella vaccine.

What happens if I overdose?

An overdose of measles, mumps, rubella, and varicella vaccine is unlikely to occur. Talk to your doctor if an overdose is suspected.

What should I avoid before or after getting measles, mumps, rubella and varicella virus vaccine?

Do not use salicylates (aspirin or aspirin containing products) for at least six weeks after receiving the vaccine. A serious condition called Reye"s Syndrome has been reported in patients with chicken pox taking salicylates.

There are no restrictions on food, beverages, or activity before or after receiving the vaccine.

What are the possible side effects of measles, mumps, rubella and varicella virus vaccine?

Getting measles, mumps, rubella, or varicella disease is much riskier than getting the vaccine. However, a vaccine, like any medicine, is capable of causing serious problems, such as severe allergic reactions. The risk of the vaccine causing serious harm, or death, is extremely small.

• a serious allergic reaction including swelling of the lips, tongue, or face; difficulty breathing; closing of the throat; hives; paleness; weakness; dizziness; or a fast heart beat;

• deafness;

• long-term seizures, coma, or lowered consciousness;

• permanent brain damage (very rare);

• seizures (jerking or staring) caused by fever; or

• temporary low platelet count, which can cause a bleeding disorder.

Signs of a serious allergic reaction would occur within a few minutes to a few hours after the shot. High fever or seizures related to the vaccine would occur 1 to 2 weeks after the shot.

Other less serious side effects may be more likely to occur. Talk to your doctor if your child experiences:

• fever;

• mild rash;

• swelling of glands in the cheeks or neck;

• pain, tenderness, or soreness.

Side effects other than those listed here may also occur. Contact your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect measles, mumps, rubella and varicella virus vaccine?

Do not use salicylates (aspirin or aspirin containing products) for at least six weeks after receiving the vaccine. A serious condition called Reye"s Syndrome has been reported in patients with chicken pox taking salicylates.

• an oral or injectable steroid medication such as betamethasone (Celestone), cortisone (Cortone), dexamethasone (Decadron, Dexone), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol), prednisolone (Prelone, Pediapred), prednisone (Orasone, Deltasone, others), or triamcinolone (Aristocort);

• an inhaled or nasal steroid such as beclomethasone (Qvar, Beclovent, Beconase, Vanceril, Vancenase), budesonide (Pulmicort, Rhinocort), flunisolide (Aerobid, Nasalide, Nasarel), fluticasone (Flovent, Flonase), mometasone (Nasonex), or triamcinolone (Azmacort, Nasacort);

• treatment for cancer with chemotherapy (medication), radiation, or x-rays;

• azathioprine (Imuran);

• basiliximab (Simulect);

• cyclosporine (Sandimmune, Neoral, Gengraf);

• etanercept (Enbrel);

• leflunomide (Arava);

• muromonab-CD3 (Orthoclone);

• mycophenolate mofetil (CellCept);

• sirolimus (Rapamune); or

• tacrolimus (Prograf).

Where can I get more information?

• Your doctor or pharmacist may have additional information or suggest additional resources regarding the vaccine.

• Remember, keep this and all other medicines out of the reach of children, never share medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.