drug-information.ru

Prandin, |Prandin

Prandin

Generic Name: repaglinide (oral) (reh PAG lih nide)
Brand Names: Prandin

What is repaglinide?

Repaglinide stimulates the pancreas to release insulin. The body needs insulin to break down sugars in food.

Repaglinide is used to treat diabetes, along with diet, exercise, and other medications in some cases.

Repaglinide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about repaglinide?

Know the signs and symptoms of low blood sugar (hypoglycemia), which include hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of sugary hard candy or glucose tablets with you to treat episodes of low blood sugar.

Follow diet, medication, and exercise routines very closely. Changing any of these routines can affect blood sugar levels.

What should I discuss with my healthcare provider before taking repaglinide?

Before taking repaglinide, tell your doctor if you

• have kidney disease;
• have liver disease;

• have Type 1 diabetes mellitus (insulin-dependent diabetes);

• have diabetic ketoacidosis;

• have a serious infection, illness, or injury; or

• need surgery.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take repaglinide?

Take repaglinide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take repaglinide before meals. It is usually taken 15 minutes before each meal. However, it can be taken immediately before a meal or up to 30 minutes before a meal. Repaglinide may be taken two, three, or four times a day. Follow your doctor"s instructions.

If you skip a meal, skip the repaglinide dose for that meal, unless otherwise directed by your doctor. If you add a meal or significantly more food to your diet than is usual, ask your doctor if you may need an additional dose of repaglinide.

What happens if I miss a dose?

If you forget to take a dose until after eating, skip that dose and take only the next regularly scheduled dose, before a meal.

What happens if I overdose?

Symptoms of a repaglinide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.

What should I avoid while taking repaglinide?

Follow diet, medication, and exercise routines very closely. Changing any of these routines can affect blood sugar levels.

Tell your doctor and dentist that you are taking this medication before having surgery.

Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor. These medications may contain sugar or alcohol or affect blood sugar levels.

Repaglinide side effects

The side effects of treatment with repaglinide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency.

Low blood sugar may occur if meals are missed or delayed after taking a dose of repaglinide; if you exercise more than usual; during illness, especially with vomiting or diarrhea; if you take other medications; after drinking alcohol; and in other situations.

Hypoglycemia, or low blood sugar, has the following symptoms: hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea.

Keep sugary hard candy; chocolate; fruit juice; or glucose tablets on hand to treat episodes of low blood sugar.

Increased blood sugar may occur if you eat significantly more food than usual; if you exercise less than usual; if you take other medications; if you have a fever or other illness; and in other situations.

Hyperglycemia, or high blood sugar, has the following symptoms: increased thirst, increased hunger, and increased urination.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect repaglinide?

Before taking repaglinide, tell your doctor if you are taking any of the following medicines:

• aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid, others), diflunisal (Dolobid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), or magnesium salicylate (Magan, Mobidin, Doan"s, others);

• a beta-blocker such as atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), propranolol (Inderal), and others;

• a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril) and others;

• a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate);

• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Aleve, Anaprox, Naprosyn, others), ketoprofen (Orudis KT, Orudis, Oruvail), and others;

• a phenothiazine such as chlorpromazine (Thorazine), perphenazine (Trilafon), and thioridazine (Mellaril);

• a steroid medication such as prednisone (Deltasone, others), methylprednisolone (Medrol, others), dexamethasone (Decadron, others), and prednisolone (Prelone, others);

• a sulfa-based drug such as sulfamethoxazole (Bactrim, Septra, others);

• a thyroid medication;

• birth control pills or estrogen replacement therapy;

• erythromycin (E-Mycin, Ery-Tab, E.E.S., others);

• ketoconazole (Nizoral) or itraconazole (Sporanox);

• phenobarbital (Luminal) or mephobarbital (Mebaral);

• phenytoin (Dilantin, Phenytek);

• probenecid;

• rifampin (Rifadin, Rimactane); or

• warfarin (Coumadin).

The medicines listed above may interact with repaglinide or affect blood sugar control. You may require a dosage adjustment or special monitoring during treatment.

Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor. These medications may contain sugar or alcohol or affect blood sugar levels.

Drugs other than those listed here may also interact with repaglinide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has additional information about repaglinide written for health professionals that you may read.

What does my medication look like?

Repaglinide is available with a prescription under the brand name Prandin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Prandin 0.5 mg--white tablets

• Prandin 1 mg--yellow tablets

• Prandin 2 mg--red tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.