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|Polymyxin B and Trimethoprim Polymyxin B and Trimethoprim Ophthalmic Solution |
| Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Polymyxin B and TrimethoprimGeneric Name: polymyxin B sulfate and trimethoprim Dosage Form: Ophthalmic solution DESCRIPTIONPolymyxin B Sulfate and Trimethoprim Ophthalmic Solution is a sterile antimicrobial solution for topical ophthalmic use. It has a pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg. Chemical Names: Trimethoprim sulfate, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine sulfate (2:1), is a white, odorless, crystalline powder with a molecular weight of 678.72 and the following structural formula:
Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2 which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formula are:
Contains: Actives: polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equivalent to trimethoprim 1mg/mL. Preservative: benzalkonium chloride 0.04 mg/mL. Inactives: sodium chloride; sulfuric acid and purified water. May also contain sodium hydroxide for pH adjustment. CLINICAL PHARMACOLOGYTrimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is very much stronger for the bacterial enzyme than for the corresponding mammalian enzyme and therefore selectively interferes with bacterial biosynthesis of nucleic acids and proteins. Polymyxin B, a cyclic lipopeptide antibiotic, is rapidly bactericidal for a variety of gram-negative organisms, especially Pseudomonas aeruginosa. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03 mcg/mL trimethoprim and 1 unit/mL polymyxin B. Microbiology: In vitro studies have demonstrated that the anti-infective components of Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution are active against the following bacterial pathogens that are capable of causing external infections of the eye: Trimethoprim: Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis (indole-negative), Proteus vulgaris (indolepositive), Enterobacter aerogenes, and Serratia marcescens. Polymyxin B: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and Haemophilus influenzae. INDICATIONS AND USAGEPolymyxin B Sulfate and Trimethoprim Ophthalmic Solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonas aeruginosa.* *Efficacy for this organism in this organ system was studied in fewer than 10 infections. CONTRAINDICATIONSPolymyxin B Sulfate and Trimethoprim Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components. WARNINGSNOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution occurs, discontinue use. Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum. PRECAUTIONSGeneralAs with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated. Information for PatientsAvoid contaminating the applicator tip with material from the eye, fingers, or other source. This precaution is necessary if the sterility of the drops is to be maintained. If redness, irritation, swelling or pain persists or increases, discontinue use immediately and contact your physician. Patients should be advised not to wear contact lenses if they have signs and symptoms of ocular bacterial infections. Carcinogenesis, Mutagenesis, Impairment of FertilityCarcinogenesisLong-term studies in animals to evaluate carcinogenic potential have not been conducted with polymyxin B sulfate or trimethoprim. MutagenesisTrimethoprim was demonstrated to be nonmutagenic in the Ames assay. In studies at two laboratories no chromosomal damage was detected in cultured Chinese hamster ovary cells at concentrations approximately 500 times human plasma levels after oral administration; at concentrations approximately 1000 times human plasma levels after oral administration in these same cells, a low level of chromosomal damage was induced at one of the laboratories. Studies to evaluate mutagenic potential have not been conducted with polymyxin B sulfate. Impairment of FertilityPolymyxin B sulfate has been reported to impair the motility of equine sperm, but its effects on male or female fertility are unknown. No adverse effects on fertility or general reproductive performance were observed in rats given trimethoprim in oral dosages as high as 70 mg/kg/day for males and 14 mg/kg/day for females. PregnancyTeratogenic EffectsPregnancy Category CAnimal reproduction studies have not been conducted with polymyxin B sulfate. It is not known whether polymyxin B sulfate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Trimethoprim has been shown to be teratogenic in the rat when given in oral doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with oral doses 6 times the human therapeutic dose. While there are no large well-controlled studies on the use of trimethoprim in pregnant women, Brumfitt and Pursell, in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or oral trimethoprim in combination with sulfamethoxazole. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter. Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nonteratogenic EffectsThe oral administration of trimethoprim to rats at a dose of 70 mg/kg/day commencing with the last third of gestation and continuing through parturition and lactation caused no deleterious effects on gestation or pup growth and survival. Nursing MothersIt is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution is administered to a nursing woman. Pediatric UseSafety and effectiveness in pediatric patients below the age of 2 months have not been established (see WARNINGS). Geriatric UseNo overall differences in safety or effectiveness have been observed between elderly and other adult patients. ADVERSE REACTIONSThe most frequent adverse reaction to Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim. DOSAGE AND ADMINISTRATIONIn mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days. HOW SUPPLIEDPolymyxin B Sulfate and Trimethoprim Ophthalmic Solution, USP is a sterile solution. Each mL contains trimethoprim sulfate equivalent to 1 mg trimethoprim and polymyxin B sulfate 10,000 units in a plastic dropper bottle of 10 mL (NDC 61314-628-10). Storage: Store at 15° - 25°C (59° - 77°F) and protect from light. Rx Only Dist. by: FALCON Pharmaceuticals, Ltd. Fort Worth, Texas 76134 Mfd. by: ALCON LABORATORIES, INC. Fort Worth, Texas 76134 USA Rev: January 2003 Printed in USA 340176-0103
Revised: 12/2006 Where can I get more information about Polymyxin B and Trimethoprim Polymyxin B and Trimethoprim Ophthalmic Solution ? 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and trimethlprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethpprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimeth0prim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimeth9prim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoorim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetholrim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetho-rim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetho0rim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopeim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopdim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopfim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoptim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethop5im ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethop4im ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprum ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprjm ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprkm ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprom ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopr9m ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopr8m ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprin ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprik ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprij ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim iphthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim kphthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim lphthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim pphthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim 0phthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim 9phthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim oohthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim olhthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim o-hthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim o0hthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opgthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opbthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opnthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opjthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim oputhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opythalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophrhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophfhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophghalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophyhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim oph6halmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim oph5halmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtgalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtbalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtnalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtjalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtualmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtyalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthzlmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthslmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthwlmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthqlmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthakmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthapmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthaomic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalnic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalkic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthaljic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmuc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmjc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmkc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmoc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalm9c solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalm8c solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmix solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmiv solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmif solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmid solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic aolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic zolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic xolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic dolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic eolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic wolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic silution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sklution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sllution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic splution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic s0lution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic s9lution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sokution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sopution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sooution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solytion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solhtion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soljtion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solition, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sol8tion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sol7tion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solurion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solufion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solugion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluyion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solu6ion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solu5ion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutuon, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutjon, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutkon, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutoon, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solut9on, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solut8on, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutiin, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutikn, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutiln, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutipn, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluti0n, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluti9n, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutiob, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutiom, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutioj, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutioh, olymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, plymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, poymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polmyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polyyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxn b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxi b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxinb and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin band trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b nd trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b ad trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b an trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b andtrimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and rimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and timethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trmethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and triethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimthoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimehoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimetoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethorim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprm polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopri polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim olymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim plymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim poymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polmyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polyyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxn b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxi b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxinb and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin band trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b nd trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b ad trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b an trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b andtrimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and rimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and timethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trmethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and triethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimthoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimehoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethorim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprm ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopri ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprimophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim phthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ohthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthlmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthamic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmi solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmicsolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic olution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic slution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soltion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluton, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutin, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutio, oplymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, ploymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, poylmyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polmyyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polyymxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymxyin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyixn b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxni b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxi nb and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxinb and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin band trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin ba nd trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b nad trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b adn trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b an dtrimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b andt rimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and rtimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and tirmethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trmiethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and triemthoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimtehoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimehtoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimetohprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethporim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethorpim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopirm polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprmi polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopri m polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim p olymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim oplymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim ploymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim poylmyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polmyyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polyymxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymxyin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyixn b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxni b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxi nb and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxinb and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin band trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin ba nd trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b nad trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b adn trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b an dtrimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b andt rimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and rtimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and tirmethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trmiethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and triemthoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimtehoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimehtoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetohprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethporim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethorpim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopirm ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprmi ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopri mophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprimo phthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim pohthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ohpthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opthhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophhtalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtahlmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthlamic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthamlic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalimc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmci solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmi csolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmics olution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic oslution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sloution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soultion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soltuion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluiton, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutoin, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutino, ppolymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, poolymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, pollymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polyymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymmyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxiin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxinn b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin bb and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b aand trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b annd trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b andd trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and ttrimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trrimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and triimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimmethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimeethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimetthoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethhoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethooprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprrim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethopriim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprimm polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim ppolymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim poolymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim pollymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polyymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymmyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxiin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxinn b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin bb and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b aand trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b annd trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b andd trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and ttrimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trrimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and triimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimmethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimeethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimetthoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethhoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethooprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprrim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethopriim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprimm ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim oophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim opphthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophhthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophtthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthhalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthaalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthallmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmiic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmicc solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic ssolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soolution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic sollution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluution, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic soluttion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutiion, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutioon, polymyxin b and trimethoprim polymyxin b and trimethoprim ophthalmic solutionn, etc.
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