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|Periostat

Periostat

Periostat is used for:

Treating periodontitis, a disease that attacks the gum, bone, and around the teeth.

Periostat is a tetracycline antibiotic. It works by suppressing the enzymes that cause periodontal breakdown and prevents the enzymes from further breaking down the gum and bone tissue around the teeth.

Do NOT use Periostat if:

• you are allergic to any ingredient in Periostat or to other tetracycline antibiotics
• you are currently taking acitretin, isotretinoin, methotrexate, a blood thinner (eg, warfarin), or typhoid vaccine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Periostat :

Some medical conditions may interact with Periostat . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diarrhea, a stomach infection, or porphyria
• if you have a history of oral yeast infections

Some MEDICINES MAY INTERACT with Periostat . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturates (eg, phenobarbital), carbamazepine, cimetidine, colestipol, hydantoins (eg, phenytoin), or rifampin because they may decrease Periostat "s effectiveness
• Acitretin, insulin, isotretinoin, methotrexate, methoxyflurane,blood thinners (eg, warfarin), or theophylline because the side effects and toxic effects may be increased by Periostat
• Penicillins (eg, amoxicillin), birth control pills, or typhoid vaccine because their effectiveness may be decreased by Periostat

This may not be a complete list of all interactions that may occur. Ask your health care provider if Periostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Periostat :

Use Periostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Periostat by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
• Do not take an antacid that has aluminum, calcium, or magnesium in it; bismuth subsalicylate; iron; zinc; or multivitamins with minerals within 2 hours before or 2 hours after you take Periostat .
• Do not eat or drink dairy products within 1 hour before or 2 hours after you take Periostat .
• To clear up your infection completely, take Periostat for the full course of treatment. Keep taking it even if you feel better in a few days.
• Drink plenty of nondairy fluid with Periostat to wash it down and avoid the risk of sore throat.
• Take Periostat twice daily (every 12 hours), preferably in the morning and evening.
• If you miss a dose of Periostat , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Periostat .

Important safety information:

• Hormonal birth control (eg, birth control pills) may not work as well while you are using Periostat . To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Periostat only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use Periostat for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Periostat may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Periostat may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Periostat . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Lab tests, including liver function, kidney function, and complete blood counts, may be performed while you use Periostat . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Periostat should be used with extreme caution in CHILDREN younger than 8 years old; safety and effectiveness in these children have not been confirmed. Use during tooth development may leave a permanent yellow-gray-brown discoloration.
• PREGNANCY and BREAST-FEEDING: Periostat has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Periostat while you are pregnant. Periostat is found in breast milk. Do not breast-feed while taking Periostat .

Possible side effects of Periostat :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back ache; bronchitis; cold; coughing; diarrhea; flu symptoms; headache; indigestion; infection; joint pain; menstrual cramps; nausea; pain; sinus congestion; sinus inflammation; sore throat; tooth disorder; toothache.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); headache and/or blurred vision; severe skin reaction to the sun; stomach pain; unusual tiredness; vaginal irritation.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Periostat at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Periostat out of the reach of children and away from pets.

General information:

• If you have any questions about Periostat , please talk with your doctor, pharmacist, or other health care provider.
• Periostat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Periostat . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.