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|Panretin

Panretin

Panretin is used for:

Treating skin sores/lesions in patients with AIDS-related Kaposi sarcoma. It may also be used to treat other conditions as determined by your doctor.

Panretin is a retinoid. It slows the growth of abnormal and normal skin cells. This slows or stops the growth of Kaposi sarcoma.

Do NOT use Panretin if:

• you are allergic to any ingredient in Panretin or to other retinoid medicines

Contact your doctor or health care provider right away if any of this applies to you.

Before using Panretin :

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have increased white blood cell counts, eczema, or lymphoma

Some MEDICINES MAY INTERACT with Panretin . Tell your health care provider if you are taking any of the following medicines.

• Tranexamic acid because side effects may be increased by Panretin .

This may not be a complete list of all interactions that may occur. Ask your health care provider if Panretin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Panretin :

Use Panretin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Panretin . Talk to your pharmacist if you have questions about this information.
• Wash and completely dry the affected area.
• Apply medicine generously to cover the lesion. Allow 3 to 5 minutes to dry before covering with clothing. Do not get Panretin on healthy skin surrounding the lesion.
• Wash your hands immediately after using Panretin , unless your hands are part of the treated area.
• Do not bandage or wrap the affected area.
• If you miss a dose of Panretin , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Panretin .

Important safety information:

• Panretin is for external use only. Do not get it in your eyes, on the inside of your nose or mouth, or near the vagina, tip of the penis, or rectum. If you get it in your eyes, rinse right away with cool water.
• Do not apply Panretin to normal skin surrounding the lesions as it may cause serious irritation to this skin.
• It may take 4 to 8 weeks or longer for Panretin to work. Do not stop using Panretin without checking with your doctor.
• Talk with your doctor before you use any other medicines or cleansers on your skin. Do NOT use insect repellants containing DEET.
• Do not shower, swim, or bathe for at least 3 hours after applying Panretin .
• You may use mineral oil between applications to help prevent dryness or itching. Do not apply mineral oil within 2 hours before or after applying Panretin .
• If severe irritation occurs, contact your doctor. You may need to temporarily stop using Panretin for a few days until the irritation stops.
• Panretin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Panretin . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Panretin contains alcohol. Do not store or use near open flames.
• Panretin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Panretin has been shown to cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Panretin while you are pregnant. It is not known if Panretin is found in breast milk. Do not breast-feed while using Panretin .

Possible side effects of Panretin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning; flaking; itching; pain; peeling; rash; redness; scaling; skin inflammation; skin irritation; stinging; tingling.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; cracking; crusting; draining; excessive pain; oozing; scabbing of the skin; swelling.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Panretin may be harmful if swallowed.

Store Panretin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Panretin out of the reach of children and away from pets.

General information:

• If you have any questions about Panretin , please talk with your doctor, pharmacist, or other health care provider.
• Panretin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Panretin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.