Ortho Evra

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NORELGESTROMIN AND ETHINYL ESTRADIOL (Systemic)

Some commonly used brand names are:

In the U.S.—

  • Ortho Evra

Not commercially available in Canada.

Category

  • Contraceptive, systemic

Description

Norelgestromin/Ethinyl Estradiol (nor-el-JES-tro-min/ ETH-in-il es-tra-DYE-ole ) contraceptive skin patch is used to prevent pregnancy. Hormones from the patch are absorbed through your skin into your body. It works by stopping a woman"s egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented.

This patch allows more estrogen into the blood than oral birth control containing the same amount of estrogen.

No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective. Discuss with your health care professional your options for birth control.

Norelgestromin/Ethinyl Estradiol does not prevent AIDS or other sexually transmitted diseases. It will not prevent, hepatitis B. It will not help as emergency contraception, such as after unprotected sexual contact.

This medicine is available only with your doctor"s prescription, in the following dosage forms:

  • Transdermal
  • Skin patch (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. If you are using the skin patch contraceptive for contraception you should understand how their benefits and risks compare to those of other birth control methods. This is a decision you, your sexual partner, and your doctor will make. For norelgestromin/ethinyl estradiol, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to estrogens or progestins. Tell your doctor if you have ever had any unusual or reaction to any other hormones. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Norelgestromin/ethinyl estradiol is not recommended during pregnancy and should be discontinued if you become pregnant or think you are pregnant. In rare cases when hormonal contraceptives have been taken by mistake early in pregnancy, problems to the fetus have not occurred. Be sure you have discussed this with your doctor.

Breast-feeding— It is not known whether norelgestromin/ethinyl estradiol passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of norelgestromin/ethinyl estradiol in children with use in other age groups. This medicine should not be used before the start of menstruation. It may be used for birth control in teenage females and has not been shown to cause different side effects or problems than it does in adults. Some teenagers may need extra information on the importance of taking norelgestromin/ethinyl estradiol exactly as prescribed.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of norelgestromin/ethinyl estradiol in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking norelgestromin/ethinyl estradiol, it is especially important that your doctor and pharmacist know if you are taking any of the following:

  • Cyclosporine (e.g., Sandimmune) or
  • Prednisolone (e.g., Prelone) or
  • Theophylline (e.g., Slo-Phyllin, Theolair-SR)—The amounts of these medicines in your blood may be too high when taken with norelgestromin/ethinyl estradiol.
  • Ampicillin or
  • Barbiturates (e.g., Amytal, Nembutal) or
  • Carbamazepine (e.g., Tegretol) or
  • Felbamate (e.g., Felbatol) or
  • Griseofulvin (e.g., Fulvicin-P/G) or
  • HIV medicines (e.g., Agnerase, Crixivan, Norvir) or
  • Oxcarbazepine (e.g., Trileptal) or
  • Phenylbutazone (e.g., Butazolidin) or
  • Phenytoin (e.g., Dilantin) or
  • Rifampin (Rifadin) or
  • Topiramate (e.g., Topamax)—Use of these medicines with norelgestromin/ethinyl estradiol may cause your contraceptive to be less effective.
  • Hypericum perforatum (e.g., St. John"s Wort)—Use of this herbal medicine with norelgestromin/ethinyl estradiol may cause your contraceptive to be less effective or cause vaginal bleeding during your cycle.
  • Smoking, tobacco—Smoking may increase the chance of causing serious blood clots, vein, or heart problems.

Other medical problems—The presence of other medical problems may affect the use of norelgestromin/ethinyl estradiol. Make sure you tell your doctor if you have any other medical problems, especially:

  • Breast cancer—current or suspected diagnosis or
  • Breast cancer—personal history or
  • Cancer of the uterus or cervix—Use of hormonal contraceptives may make these conditions worse.
  • Jaundice during pregnancy or from using hormonal therapy in the past or
  • Liver cancer, disease or tumors—Use of hormonal contraceptives may increase the chance of liver problems or make liver conditions worse.
  • Diabetes mellitus (sugar diabetes)—Use of hormonal contraceptives may cause an increase, usually only a small increase, in your blood sugar and usually does not affect the amount of diabetes medicine that you take. You or your doctor will want to test for any changes in your blood sugar.
  • Depression or
  • Gallbladder disease or
  • Heart attack or
  • Heart disease, now or in the past or
  • High blood pressure or
  • Stroke, now or in the past—Use of hormonal contraceptives may cause or worsen these conditions.
  • Abnormal or unusual vaginal bleeding—This condition may sometimes be treated with hormone contraceptives, but may make this condition worse.
  • Migraine headache, new or worse or a new kind of headache—Use of hormonal contraceptives may cause headaches to be worse.
  • Obesity—Use of the transdermal patch may be less effective in women with body weight greater than or equal to 198 pounds (90 kilograms).
  • Problems with circulation or blood clots, now or in the past or
  • Problems with heart valves or
  • Surgery with a long period of inactivity—Use of hormonal contraceptives may increase the chance of blood clots and worsen these conditions.

Proper Use of This Medicine

To make using hormonal contraceptives as safe and reliable as possible, you should understand how and when to use them and what effects may be expected.

A paper with information for the patient will be given to you with your filled prescription, and will provide many details concerning the use of hormonal contraceptives. Read this paper carefully and ask your health care professional if you need additional information or explanation.

When you begin using norelgestromin and ethinyl estradiol, your body will require at least 7 days to adjust before a pregnancy will be prevented. Use a second form of contraception, such as a condom, spermicide, or diaphragm, for the first 7 days of your first cycle.

Keep each patch in the package until you are ready to use it. Apply the patch to clean, dry skin on the abdomen, upper body, the upper outside part of the arm, or the buttocks. Avoid touching the sticky surface of the patch. Make sure there is no lotion, powder, cream, or make-up on the skin. Apply the patch and then press it with the palm of your hand for 10 seconds to make sure it sticks. Change the location of the patch each time you apply a new one. Do not apply a patch to skin that is injured, broken, or cut. Do not apply a patch to your breasts. Check the patch every day to make sure it is in place.

If the patch comes off partly or all the way, try to apply it again or apply a new patch. If it was loose less than 24 hours, no other form of birth control is needed. If the patch has peeled away for more than 24 hours, apply a new patch and start a new cycle. A second form of birth control should be used.

If the patch is not sticky or has stuck to material or itself, remove it and apply a new patch. Do not hold the patch in place with tape or wraps.

If you are switching from a contraceptive pill to using the patch, start the patch on the first day of your period. If you do not start your period after 5 days, you see your health care professional for a pregnancy test. If you start the patch later than the first day of your period, use a second method of birth control with the patch for the first 7 days.

If you have had a baby and are not breast-feeding, you should wait 4 weeks before you start this medicine. If you have not had a period after having your baby, you should make sure you are not pregnant before starting this medicine.

If you have a miscarriage or an abortion in the first trimester of your pregnancy, you may start norelgestromin/ethinyl estradiol right away. You do not need a second form of birth control. If you start this medicine 5 days or more after the miscarriage or abortion, you should use a second form of birth control with the patch for the first 7 days. If you have a miscarriage or abortion after the first trimester, you should wait 4 weeks before starting this medicine

If you have bleeding with the patch in place, continue to use the patches as usual. If the bleeding continues for 2-3 cycles, call your health care professional. If you do not have your period during the time the patch is off stay on your regular schedule and call your health care professional.

If the patch is uncomfortable or causing irritation, change to a new patch in a new location. Change the patch again on your regular schedule. Do not use more than one patch at a time.

When you remove a patch, carefully fold it in half so that it sticks to itself and throw it away. There will still be some hormones on the patch. Do not touch the inside of the patch.

Dosing—Your health care professional may begin your patch on the first day of your menstrual period (called Day-1 start) or on Sunday (called Sunday start). When you begin on a certain day it is important that you follow that schedule, even if you forget to change a patch . Do not change your schedule on your own . If the schedule that you have been put on is not convenient, check with your health care professional about changing schedules.

  • For transdermal dosage form (skin patch):
    • For contraception (to prevent pregnancy):
      • Adults—Apply 1 patch to the skin and keep it in place for 1 week. Apply a new patch at the beginning of week 2 and again at week 3. Always change the patch on the same day of the week. Do not use a patch during week 4. This is when you will have your period. Start a new patch 7 days after the last patch was removed.
      • Children—Use and dose must be determined by your doctor.

Missed dose—Follow your doctor"s orders or the directions on the label if you forget to change your patch. The following information includes only some of the ways to handle this. Your health care professional may want you to stop taking the medicine and use other birth control methods for the rest of the month until you have your menstrual period. Then your health care professional can tell you how to begin taking your medicine again.

  • If you forget to apply your patch during the 1st week, apply it as soon as possible and start a new cycle. Use a second form of birth control for the first week of the new cycle. You will now have a new patch start day.
  • If you forget to change your patch in the 2nd or 3rd week for one or two days, change it as soon as you remember. No other form of birth control is needed.
  • If you forget to change your patch in the 2nd or 3rd week for more than two days, change to a new patch and start a new cycle. Use a second form of birth control for the first week of the new cycle
  • If you forget to remove your patch at the end of the 3rd week, remove it as soon as possible and then start a new patch on your regular start day. You should never have the patch off for more than 7 days in a row.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store patches in their protective pouches.
  • Do not refrigerate.
  • Do not freeze.
  • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects. These visits will usually be every 6 to 12 months, but some doctors require them more often.

Tell the medical doctor or dentist in charge that you are taking this medicine before any kind of surgery (including dental surgery) or emergency treatment . Your doctor will decide whether you should continue taking this medicine.

Norelgestromin/ethinyl estradiol may not work as well for you if you weigh more than 198 pounds. Talk to your health care professional about the kind of birth control that is best for you.

Vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is sometimes called spotting when slight, or breakthrough bleeding when heavier. If this should occur:

  • Continue on your regular dosing schedule.
  • The bleeding usually stops within 1 week.
  • Check with your doctor if the bleeding continues for more than 1 week.
  • After you have been taking hormonal contraceptives on schedule and for more than 3 months and bleeding continues, check with your doctor.

Missed menstrual periods may occur:

  • If you have not used the patch exactly as scheduled. Pregnancy must be considered as a possibility.
  • If the medicine is not the right strength or type for your needs.

Check with your health care professional if you miss any menstrual periods so that the cause may be determined.

If you suspect that you may have become pregnant, stop taking this medicine immediately and check with your doctor .

Check with your doctor before refilling an old prescription, especially after a pregnancy. You will need another physical examination and your doctor may change your prescription.

Side Effects of This Medicine

Healthy women who do not smoke cigarettes have almost no chance of having a severe side effect from using hormonal contraceptives. For most women, more problems occur because of pregnancy than will occur from using hormonal contraceptives. But for some women who have special health problems, hormonal contraceptives can cause some unwanted effects. Some of these unwanted effects include heart disease, heart attack, benign (not cancerous) liver tumors, liver cancer, or blood clots or related problems, such as a stroke. Although these effects are very rare, they can be serious enough to cause death. You may want to discuss these effects with your doctor.

Other health problems that may be affected by using hormonal contraceptives are high blood pressure, high cholesterol, diabetes and being overweight.

Smoking cigarettes during the use of hormonal contraceptives has been found to greatly increase the chances of these serious side effects occurring. This risk increases with heavy smoking (15 or more cigarettes a day) or if you are over 35 years old. To reduce the risk of serious side effects, do not smoke cigarettes while you are taking hormonal contraceptives .

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Use with caution around small children. The contraceptive patch may be a choking hazard if swallowed by a child.

More common

Body aches or pain

chills; cough; difficulty breathing; ear congestion; fever; headache; loss of voice; nasal congestion; runny nose; sneezing; sore throat; unusual tiredness or weakness

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur

Nausea; vomiting; unusual vaginal bleeding in women

Frequency unknown

Anxiety; changes in skin color; chest pain or discomfort; confusion; dark urine; diarrhea; eye pain; dizziness; fainting; inability to speak; itching; lack or loss of appetite; light-colored stools; lightheadedness; nausea; nervousness; numbness in hands; pain in abdomen; pain in chest, groin, or legs, especially the calves; pain, tenderness, or swelling of foot or leg; pain or discomfort in arms, jaw, back or neck; pounding in the ears; rash; seizures; slow or fast heartbeat; slurred speech; sudden headache; sudden loss of coordination; sudden, severe weakness or numbness in arm or leg on one side of the body; sudden, unexplained shortness of breath; sweating; swelling, pain, or tenderness in upper abdominal area; temporary blindness; unpleasant breath odor; vision changes; vomiting of blood; yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More Common

Burning, itching, or redness of skin; menstrual cramps; pain, soreness, swelling, or discharge from the breast or breasts; swelling or soreness at patch site

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Frequency unknown

Abdominal cramps or bloating; absent, missed, or irregular menstrual periods; bloody vaginal discharge; brown, blotchy spots on exposed skin; change in amount of vaginal discharge; change in menstrual flow; decreased amount of breast milk; discouragement; dry mouth; feeling sad or empty; increased hunger or thirst; increase or decrease in weight; increased urination; irritability; itching of the vagina or outside genitals; light vaginal bleeding between periods and after sexual intercourse; loss of interest or pleasure; pain during sexual intercourse; stopping of menstrual bleeding; swelling; thick, white curd-like vaginal discharge without odor or with mild odor; trouble concentrating; trouble sleeping; unusual vaginal bleeding; vomiting

Developed: 04/15/2002
Revised: 11/29/2005

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