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Oncaspar, |Oncaspar

Oncaspar

Generic Name: pegaspargase (peg ah SPAR jase)
Brand Names: Oncaspar

What is pegaspargase?

Pegaspargase is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Pegaspargase is used to treat acute lymphoblastic leukemia.

Pegaspargase may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pegaspargase?

Before receiving pegaspargase, tell your doctor if you are allergic to any drugs, or if you have diabetes or a bleeding disorder such as hemophilia.

While receiving pegaspargase, avoid being near with people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Call your doctor at once if you have any of the following side effects during your treatment with pegaspargase:

• severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• pain or swelling in one or both legs;

• fever, chills, body aches, flu symptoms;

• easy bruising or bleeding, unusual weakness;

• increased thirst or urination; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

What should I discuss with my health care provider before receiving pegaspargase?

• a serious allergic reaction;

• a stroke or blood clot; or

• problems with your pancreas.

Before receiving pegaspargase, tell your doctor if you are allergic to any drugs, or if you have:

• diabetes (pegaspargase can raise blood sugar); or

• a bleeding or blood clotting disorder such as hemophilia.

If you have any of these conditions, you may not be able to receive pegaspargase, or you may need a dosage adjustment or special tests during treatment.

How is pegaspargase given?

Pegaspargase is given as an injection through an IV needle placed into a vein, or as a shot into a muscle. You will receive this injection in a clinic or hospital setting. The IV medicine must be given slowly, and it can take up to 2 hours to complete.

After receiving this medication, your doctor may want to observe you for at least 1 hour to make sure the medication does not cause harmful side effects.

Before you receive your first treatment with this medication, you may need a skin test to make sure you are not allergic to pegaspargase.

This medication can cause you to have unusual results with certain thyroid tests. Tell any doctor who treats you that you are receiving pegaspargase.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your pegaspargase injection.

What happens if I overdose?

What should I avoid while receiving pegaspargase?

Avoid being near with people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Pegaspargase side effects

• severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• pain or swelling in one or both legs;

• fever, chills, body aches, flu symptoms;

• easy bruising or bleeding, unusual weakness;

• increased thirst or urination; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may be more likely to occur, such as:

• mild skin rash or itching;

• depression, drowsiness;

• swelling in your hands, ankles, or feet;

• nausea, vomiting, loss of appetite, weight loss;

• stomach cramps; or

• headache, feeling tired or irritable.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pegaspargase?

Before receiving asparaginse, tell your doctor if you are using any of the following drugs:

• vincristine (Oncovin, Vincasar);

• prednisone (Deltasone, Meticorten, Orasone, and others); or

• methotrexate (Folex, Rheumatrex, Trexall).

If you are using any of these drugs, you may not be able to receive pegaspargase, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect pegaspargase. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about pegaspargase written for health professionals that you may read.

What does my medication look like?

Pegaspargase is available with a prescription under the brand name Oncaspar. Other brand or generic formulations may also be available. Ask your healthcare provider or pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.