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|Nystatin Ointment Nystatin Oral Suspension

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Nystatin

Dosage Form: Ointment

Rx only

Nystatin Description

Nystatin Ointment USP, for topical use only, contains 100,000 USP Nystatin Units per gram, in a polyethylene and mineral oil base. The structural formula is as follows:

Nystatin - Clinical Pharmacology

Nystatin is an antifungal antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. It probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components. Nystatin is a polyene antibiotic that is obtained from Streptomyces noursei, and is the first well tolerated antifungal antibiotic of dependable efficacy for the treatment of cutaneous, oral and intestinal infections caused by Candida [Monilia]albicans and other Candida species. It exhibits no appreciable activity against bacteria.

Nystatin provides specific therapy for all localized forms of candidiasis. Symptomatic relief is rapid, often occurring within 24 to 72 hours after the initiation of treatment. Cure is effected both clinically and mycologically in most cases of localized candidiasis.

Indications and Usage for Nystatin

Nystatin Ointment is indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida [Monilia]albicans and other Candida species.

Contraindications

Nystatin Ointment is contraindicated in patients with a history of hypersensitivity to any of its components.

Precautions

Should a reaction of hypersensitivity occur the drug should be immediately withdrawn and appropriate measures taken.

This preparation is not for ophthalmic use.

Adverse Reactions

Nystatin is virtually non-toxic and nonsensitizing and is well tolerated by all age groups including debilitated infants, even on prolonged administration. If irritation on topical application should occur, discontinue medication.

Nystatin Dosage and Administration

Nystatin Ointment should be applied liberally to affected areas twice a day or as indicated until healing is complete. Nystatin cream is usually preferred to Nystatin ointment in candidiasis involving intertriginous areas; very moist lesions, however, are best treated with Nystatin topical powder.

This preparation does not stain skin or mucous membranes and provides a simple, convenient means of treatment.

How is Nystatin Supplied

Nystatin Ointment (100,000 USP Nystatin Units per gram) is a yellow ointment available as follows:

NDC 0168-0007-15 15 gram tube

NDC 0168-0007-30 30 gram tube

Store at controlled room temperature 15°- 30°C (59°-86°F).

E. FOUGERA & CO.
a division of Altana Inc.
MELVILLE, NEW YORK 11747
I20715F
R12/98
#21

Nystatin (Nystatin)

PRODUCT INFO
Product Code	0168-0007	Dosage Form	OINTMENT
Route Of Administration	TOPICAL	DEA Schedule

INGREDIENTS
Name (Active Moiety)	Type	Strength
Nystatin (Nystatin)	Active	100000 UNITS In 1 GRAM
mineral oil	Inactive
polyethylene	Inactive

IMPRINT INFORMATION
Characteristic	Appearance	Characteristic	Appearance
Color		Score
Shape		Symbol
Imprint Code		Coating
Size

PACKAGING
#	NDC	Package Description	Multilevel Packaging
1	0168-0007-15	15 GRAM In 1 TUBE	None
2	0168-0007-30	30 GRAM In 1 TUBE	None

Revised: 11/2006

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