drug-information.ru

|Nafcillin Sodium

Drugs search, click the first letter of a drug name:

| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home

Nafcillin Sodium

Pronouncation: (naff-SILL-in SO-dee-uhm)
Class: Penicillinase-resistant penicillin

Trade Names:
Nafcillin Sodium
- Injection 1 g (as base)
- Injection 2 g (as base)

Mechanism of Action

Pharmacology

Inhibits bacterial cell wall mucopeptide synthesis.

Pharmacokinetics

Absorption

T _max is 0.5 to 1 hr.

Distribution

Nafcillin is widely distributed in various body fluids (eg, bile, pleural, amniotic, synovial) and has high CSF penetration in presence of inflamed meninges. Protein binding is 89.9%, mainly albumin.

Metabolism

Nafcillin is metabolized mainly in the liver.

Elimination

Nafcillin is excreted in urine (30% as unchanged), and primarily eliminated in bile. Serum t _{1/ 2} is 33 to 61 min (IV).

Special Populations

Biliary obstruction and cirrhosis

Plasma clearance is significantly decreased and excretion in urine was significantly increased from approximately 30% to 50%.

Indications and Usage

Treatment of infections caused by penicillinase-producing staphylococci.

Contraindications

Standard considerations.

Dosage and Administration

Adults

IV Usual, 500 mg q 4 hr. Severe infections, 1 g q 4 hr. Infuse over at least 30 to 60 min.

General Advice

For IV administration only. Do not administer intradermal, SC, or IM.
Thaw frozen container at room temperature (77°F) or under refrigeration (41°F). Do not force thawing by immersion in water or by microwave irradiation.
Check thawed IV container for minute leaks by squeezing bag firmly. If leaks are detected discard solution because sterility may be impaired.
Agitate thawed IV container and inspect visually. Do not administer if thawed solution is cloudy, discolored, or contains particulate matter or if any seal or outlet port is not intact.
Do not add other medications to IV container.

Storage/Stability

Store IV bag in freezer at -4°F. Thawed solutions are stable for 21 days under refrigeration (41°F) or for 72 hr at room temperature (77°F). Do not refreeze thawed solutions.

Drug Interactions

Cyclosporine

May reduce blood levels of cyclosporine.

Disulfiram

May increase nafcillin levels.

Probenecid

May increase nafcillin levels.

Tetracycline

May reduce effectiveness of nafcillin.

Warfarin

May increase warfarin effects.

Laboratory Test Interactions

May cause false-positive urine reaction for protein when the sulfosalicylic acid test is used.

Adverse Reactions

GI

Pseudomembranous colitis.

Genitourinary

Renal tubular damage; interstitial nephritis.

Hypersensitivity

Immediate hypersensitivity reactions including urticaria; pruritus; angioneurotic edema; laryngospasm; bronchospasm; hypotension; vascular collapse. Delayed reactions including fever, malaise, urticaria, myalgia, arthralgia, abdominal pain, and rashes.

Metabolic

Agranulocytosis; neutropenia; bone marrow depression.

Miscellaneous

Local reactions include pain, swelling, phlebitis, thrombophlebitis, inflammation at the injection site.

Precautions

Pregnancy

Category B .

Lactation

Secreted into breast milk.

Children

Excretion may be impaired in newborns. Not approved for IV use in neonates or children.

Hypersensitivity

Use with caution in patients with histories of significant allergies to penicillins or asthma.

Renal Function

May reduce nafcillin elimination.

Hepatic Function

May reduce nafcillin elimination.

Superinfection

May result in overgrowth of nonsusceptible organisms.

Patient Information

Explain name, dose, action, and potential side effects of drug.
Explain to patient or caregiver that medication is usually prepared and administered by a health care provider in a health care setting but may be used at home in some situations if ordered by the patient"s health care provider.
If patient or caregiver is administering at home ensure that the patient or caregiver understands how to store, prepare and administer the dose, and dispose of used equipment and supplies. The first injection should be performed under the supervision of a qualified health professional.
Review dosing schedule and prescribed length of therapy with patient. Advise patient that dose and duration of therapy are dependent on site and cause of infection and response to therapy.
Instruct patient to report the following to health care provider: itching; rash; hives; difficulty breathing; diarrhea; loose, foul-smelling stools; injection site reaction.
Advise patient that follow-up visits and lab tests may be needed to monitor therapy and to keep appointments.

Where can I get more information about Nafcillin Sodium ? We recommend to use www.Drugs.com

Typical mistypes for Nafcillin Sodium
bafcillin sodium, mafcillin sodium, jafcillin sodium, hafcillin sodium, nzfcillin sodium, nsfcillin sodium, nwfcillin sodium, nqfcillin sodium, nadcillin sodium, naccillin sodium, navcillin sodium, nagcillin sodium, natcillin sodium, narcillin sodium, nafxillin sodium, nafvillin sodium, naffillin sodium, nafdillin sodium, nafcullin sodium, nafcjllin sodium, nafckllin sodium, nafcollin sodium, nafc9llin sodium, nafc8llin sodium, nafciklin sodium, nafciplin sodium, nafciolin sodium, nafcilkin sodium, nafcilpin sodium, nafciloin sodium, nafcillun sodium, nafcilljn sodium, nafcillkn sodium, nafcillon sodium, nafcill9n sodium, nafcill8n sodium, nafcillib sodium, nafcillim sodium, nafcillij sodium, nafcillih sodium, nafcillin aodium, nafcillin zodium, nafcillin xodium, nafcillin dodium, nafcillin eodium, nafcillin wodium, nafcillin sidium, nafcillin skdium, nafcillin sldium, nafcillin spdium, nafcillin s0dium, nafcillin s9dium, nafcillin sosium, nafcillin soxium, nafcillin socium, nafcillin sofium, nafcillin sorium, nafcillin soeium, nafcillin soduum, nafcillin sodjum, nafcillin sodkum, nafcillin sodoum, nafcillin sod9um, nafcillin sod8um, nafcillin sodiym, nafcillin sodihm, nafcillin sodijm, nafcillin sodiim, nafcillin sodi8m, nafcillin sodi7m, nafcillin sodiun, nafcillin sodiuk, nafcillin sodiuj, afcillin sodium, nfcillin sodium, nacillin sodium, nafillin sodium, nafcllin sodium, nafcilin sodium, nafcilin sodium, nafcilln sodium, nafcilli sodium, nafcillinsodium, nafcillin odium, nafcillin sdium, nafcillin soium, nafcillin sodum, nafcillin sodim, nafcillin sodiu, anfcillin sodium, nfacillin sodium, nacfillin sodium, naficllin sodium, nafclilin sodium, nafcililn sodium, nafcillni sodium, nafcilli nsodium, nafcillins odium, nafcillin osdium, nafcillin sdoium, nafcillin soidum, nafcillin soduim, nafcillin sodimu, nnafcillin sodium, naafcillin sodium, naffcillin sodium, nafccillin sodium, nafciillin sodium, nafcilllin sodium, nafcilllin sodium, nafcilliin sodium, nafcillinn sodium, nafcillin sodium, nafcillin ssodium, nafcillin soodium, nafcillin soddium, nafcillin sodiium, nafcillin sodiuum, nafcillin sodiumm, etc.