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|Metopirone

Metopirone

Metopirone is used for:

Testing pituitary function.

Metopirone is a diagnostic aid. It works by blocking the body"s natural production of cortisol and corticosterone. This causes the pituitary gland to increase production of corticotropin (ACTH), which causes an increase in the body"s production of certain chemicals. These chemicals can be measured in the urine to determine how well the pituitary gland is working.

Do NOT use Metopirone if:

• you are allergic to any ingredient in Metopirone
• you have certain adrenal gland problems (adrenal cortical insufficiency) or are taking a corticosteroid (eg, prednisone)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Metopirone :

Some medical conditions may interact with Metopirone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of adrenal gland or thyroid gland problems

Some MEDICINES MAY INTERACT with Metopirone . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Insulin or oral hypoglycemics (eg, glyburide) because the side effects of Metopirone may be increased
• Corticosteroids (eg, prednisone), estrogen, or hydantoins (eg, phenytoin) because the effectiveness of Metopirone may be decreased
• Acetaminophen because the risk of liver toxicity may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metopirone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metopirone :

Use Metopirone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Metopirone with food or milk.
• Do not miss any doses. If you are using Metopirone for a diagnostic test and miss a dose, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Metopirone .

Important safety information:

• Metopirone may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Metopirone . Using Metopirone alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Use Metopirone with caution in the ELDERLY because they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Metopirone , discuss with your doctor the benefits and risks of using Metopirone during pregnancy. It is unknown if Metopirone is excreted in breast milk. If you are or will be breast-feeding while you are using Metopirone , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Metopirone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; nausea; stomach pain; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; confusion; dehydration; diarrhea; fast or irregular heartbeat; severe dizziness or drowsiness; weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include anxiety; confusion; dehydration; diarrhea; fast or irregular heartbeat; severe dizziness or drowsiness; weakness.

Store Metopirone at room temperature below 86 degrees F (30 degrees C). Keep Metopirone out of the reach of children and away from pets.

General information:

• If you have any questions about Metopirone , please talk with your doctor, pharmacist, or other health care provider.
• Metopirone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Metopirone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.