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|Methyprylon

METHYPRYLON (Systemic)*†

*† Not commercially available in the U.S. and Canada.

Category

• Sedative-hypnotic

Description

Methyprylon (meth-i-PRYE-lon) is used to treat insomnia (trouble in sleeping). However, it has generally been replaced by other medicines for the treatment of insomnia. If methyprylon is used regularly (for example, every day) to help produce sleep, it may not be effective for more than 1 week.

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For methyprylon, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to methyprylon. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Methyprylon has not been studied in pregnant women. However, it has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding—It is not known whether methyprylon passes into the breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children—Studies on this medicine have been done only in adult patients and there is no specific information about its use in children.

Older adults—Elderly people may be especially sensitive to the effects of methyprylon. This may increase the chance of side effects during treatment.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking methyprylon, it is especially important that your health care professional know if you are taking any of the following:

• Central nervous system (CNS) depressants, other—Using these medicines with methyprylon may increase the CNS and other depressant effects

Other medical problems—The presence of other medical problems may affect the use of methyprylon. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease or
• Liver disease—Higher blood levels of methyprylon may occur, increasing the chance of side effects

• Porphyria—Methyprylon may make the condition worse

Proper Use of This Medicine

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming.

Storage—To store this medicine:

• Keep out of the reach of children. Overdose of methyprylon is especially dangerous in children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If you will be taking this medicine regularly for a long time:

• Your doctor should check your progress at regular visits.
• Do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine .

If you think you or someone else may have taken an overdose of this medicine, get emergency help at once . Taking an overdose of methyprylon or taking alcohol or other CNS depressants with methyprylon may lead to unconsciousness and possibly death. Some signs of an overdose are confusion, fast heartbeat, severe weakness, shortness of breath or slow or troubled breathing, and staggering.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert .

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:

Confusion; convulsions (seizures); hallucinations (seeing, hearing, or feeling things that are not there); increased dreaming; increased sweating; nausea or vomiting; nightmares; restlessness or nervousness; stomach cramps; trembling; trouble in sleeping; unusual weakness

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 10/13/2000

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