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|Metformin hydrochloride Metformin Hydrochloride

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Metformin hydrochloride

Generic name: Metformin hydrochloride
Brand names: Glucophage

Why is Metformin hydrochloride prescribed?

Metformin hydrochloride is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. Diabetes develops when the body proves unable to burn sugar and the unused sugar builds up in the bloodstream. Metformin hydrochloride lowers the amount of sugar in your blood by decreasing sugar production and absorption and helping your body respond better to its own insulin, which promotes the burning of sugar. It does not, however, increase the body"s production of insulin.

Metformin hydrochloride is sometimes prescribed along with insulin or certain other oral antidiabetic drugs such as Micronase or Glucotrol. It is also used alone.

Standard Metformin hydrochloride tablets are taken two or three times daily. An extended-release form (Metformin hydrochloride XR) is available for once-daily dosing.

Always remember that Metformin hydrochloride is an aid to, not a substitute for, good diet and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications such as dangerously high or low blood sugar levels. Remember, too, that Metformin hydrochloride is not an oral form of insulin and cannot be used in place of insulin.

Most important fact about Metformin hydrochloride

Metformin hydrochloride could cause a very rare--but potentially fatal--side effect known as lactic acidosis. It is caused by a buildup of lactic acid in the blood. The problem is most likely to occur in people whose liver or kidneys are not working well, and in those who have multiple medical problems, take several medications, or have congestive heart failure. The risk also is higher if you are an older adult or drink alcohol. Lactic acidosis is a medical emergency that must be treated in a hospital. Notify your doctor immediately if you experience any of the following:

Symptoms of lactic acidosis may include:
Dizziness, extreme weakness or tiredness, light-headedness, low body temperature, rapid breathing or trouble breathing, sleepiness, slow or irregular heartbeat, unexpected or unusual stomach discomfort, unusual muscle pain

How should you take Metformin hydrochloride?

Do not take more or less of Metformin hydrochloride than directed by your doctor. The drug should be taken with food to reduce the possibility of nausea or diarrhea, especially during the first few weeks of therapy.

If taking Metformin hydrochloride XR, be sure to swallow the tablet whole; do not crush it or chew it. The inactive ingredients in the tablet may occasionally appear in the stool. This is not a cause for concern.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store it at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Metformin hydrochloride.

If side effects from Metformin hydrochloride occur, they usually happen during the first few weeks of therapy. Most side effects are minor and will go away after you"ve taken Metformin hydrochloride for a while.

More common side effects may include:
Abdominal discomfort, diarrhea, gas, headache, indigestion, nausea, vomiting, weakness

Why should Metformin hydrochloride not be prescribed?

Metformin hydrochloride is processed primarily by the kidneys, and can build up to excessive levels in the body if the kidneys aren"t working properly. It should be avoided if you have kidney disease or your kidney function has been impaired by a condition such as shock, blood poisoning, or a heart attack.

You should not use Metformin hydrochloride if you need to take medicine for congestive heart failure.

Do not take Metformin hydrochloride if you have ever had an allergic reaction to metformin.

Do not take Metformin hydrochloride if you have metabolic or diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity breath). Diabetic ketoacidosis should be treated with insulin.

Special warnings about Metformin hydrochloride

Before you start therapy with Metformin hydrochloride, and at least once a year thereafter, your doctor will do a complete assessment of your kidney function. If you develop kidney problems while on Metformin hydrochloride, your doctor will discontinue Metformin hydrochloride. If you are an older person, you will need to have your kidney function monitored more frequently, and your doctor may want to start you at a lower dosage.

You should not take Metformin hydrochloride for 2 days before and after having an X-ray procedure (such as an angiogram) that uses an injectable dye. Also, if you are going to have surgery, except minor surgery, you should stop taking Metformin hydrochloride. Once you have resumed normal food and fluid intake, your doctor will tell you when you can start drug therapy again.

Avoid drinking too much alcohol while taking Metformin hydrochloride. Heavy drinking increases the danger of lactic acidosis and can also trigger an attack of low blood sugar.

Because poor liver function could increase the risk of lactic acidosis, your doctor may decide to check your liver function before prescribing Metformin hydrochloride and periodically thereafter. If you develop liver problems, your doctor may stop treatment with Metformin hydrochloride.

If you are taking Metformin hydrochloride, you should check your blood or urine periodically for abnormal sugar (glucose) levels. Your doctor will do annual blood checks to see if Metformin hydrochloride is causing a vitamin B₁₂ deficiency or any other blood problem.

Metformin hydrochloride does not usually cause hypoglycemia (low blood sugar). However, it remains a possibility, especially in older, weak, and undernourished people and those with kidney, liver, adrenal, or pituitary gland problems. The risk of low blood sugar increases when Metformin hydrochloride is combined with other diabetes medications. The risk is also boosted by missed meals, alcohol, and excessive exercise. To avoid low blood sugar, you should closely follow the diet and exercise plan suggested by your doctor.

If your blood sugar becomes unstable due to the stress of a fever, injury, infection, or surgery, your doctor may temporarily take you off Metformin hydrochloride and ask you to take insulin instead.

You should stop taking Metformin hydrochloride if you become seriously dehydrated, since this increases the likelihood of developing lactic acidosis. Tell your doctor if you lose a significant amount of fluid due to vomiting, diarrhea, fever, or some other condition.

The effectiveness of any oral antidiabetic, including Metformin hydrochloride, may decrease with time. This may occur because of either a diminished responsiveness to the medication or a worsening of the diabetes.

Possible food and drug interactions when taking Metformin hydrochloride

If Metformin hydrochloride is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Metformin hydrochloride with the following:

Amiloride (Moduretic)
Calcium channel blockers (heart medications) such as Calan, Isoptin, and Procardia
Cimetidine (Tagamet)
Decongestant, airway-opening drugs such as Sudafed and Ventolin
Digoxin (Lanoxin)
Estrogens such as Premarin
Furosemide (Lasix)
Glyburide (Micronase)
Isoniazid (Rifamate), a drug used for tuberculosis
Major tranquilizers such as Thorazine
Morphine
Niacin (Niaspan)
Nifedipine (Adalat, Procardia)
Oral contraceptives
Phenytoin (Dilantin)
Procainamide (Procanbid, Pronestyl)
Quinidine (Quinidex)
Quinine
Ranitidine (Zantac)
Steroids such as prednisone (Deltasone)
Thyroid hormones such as Synthroid
Triamterene (Dyazide, Dyrenium)
Trimethoprim (Bactrim, Septra)
Vancomycin (Vancocin)
Water pills (diuretics) such as HydroDIURIL, Dyazide, and Moduretic

Do not drink too much alcohol, since excessive alcohol consumption can cause low blood sugar and alcohol enhances some effects of Metformin hydrochloride.

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, tell your doctor immediately. Metformin hydrochloride should not be taken during pregnancy. Since studies suggest the importance of maintaining normal blood sugar (glucose) levels during pregnancy, your doctor may prescribe insulin injections instead.

It is not known whether Metformin hydrochloride appears in human breast milk. Therefore, women should discuss with their doctors whether to discontinue the medication or to stop breastfeeding. If the medication is discontinued and if diet alone does not control glucose levels, then your doctor may consider insulin injections.

Recommended dosage

Your doctor will tailor your dosage to your individual needs.

ADULTS

Metformin hydrochloride

The usual starting dose is one 500-milligram tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily dose by 500 milligrams at weekly intervals, based on your response up to a total of 2,000 milligrams.

An alternative starting dose is one 850-milligram tablet a day, taken with the morning meal. Your doctor may increase this by 850 milligrams at 14-day intervals, to a maximum of 2,550 milligrams a day.

The usual maintenance dose ranges from 1,500 to 2,550 milligrams daily. If you take more than 2,000 milligrams a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.

Metformin hydrochloride XR

The usual starting dose is one 500-milligram tablet once daily with the evening meal. Your doctor may increase your dose by 500 milligrams at weekly intervals, up to a maximum dosage of 2,000 milligrams a day. If a single 2,000-milligram dose fails to control your blood sugar, you may be asked to take 1,000-milligram doses twice a day. If you need more than 2,000 milligrams a day, the doctor will switch you to regular Metformin hydrochloride.

CHILDREN

Metformin hydrochloride

For children 10 to 16 years old, the usual starting dose is one 500-milligram tablet twice a day with meals. The dosage may be increased by 500 milligrams at weekly intervals up to a maximum of 2,000 milligrams daily. Metformin hydrochloride has not been tested in children younger than 10.

Metformin hydrochloride XR

This form of the drug has not been tested in children younger than 17.

OLDER ADULTS

Older people and those who are malnourished or in a weakened state are generally given lower doses of Metformin hydrochloride because their kidneys may be weaker, making side effects more likely.

Overdosage

An overdose of Metformin hydrochloride can cause lactic acidosis (see "Most important fact about Metformin hydrochloride"). If you suspect a Metformin hydrochloride overdose, seek emergency treatment immediately.

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