Memantine
 Memantine Hydrochloride

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|Memantine Memantine Hydrochloride

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Memantine

Generic name: Memantine
Brand names: Namenda

Why is Memantine prescribed?

Memantine is a new kind of medication used for treating moderate to severe Alzheimer"s disease. While other Alzheimer"s drugs work to prevent the breakdown of the brain chemical acetylcholine, Memantine works by targeting glutamate. Both chemicals are associated with memory and learning. Studies show that Memantine can help improve the mental state and daily functioning of some people with Alzheimer"s disease.

Most important fact about Memantine

Remember that Memantine does not cure or slow the progression of Alzheimer"s disease; it merely treats the symptoms.

How should you take Memantine?

Memantine should be taken exactly as prescribed. The dose of Memantine is increased gradually at 1-week intervals. Be sure to wait at least 1 week before increasing the dose. Using doses that are higher than recommended provides no additional benefit. Memantine may be taken with or without food.

--If you miss a dose...

Give the forgotten dose as soon as you remember. However, if it is almost time for the next dose, skip the one you missed and return to your regular schedule. Do not give two doses at once.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Memantine.

  • More common side effects may include:
    Confusion, constipation, coughing, dizziness, hallucinations, headache, high blood pressure, pain, sleepiness, vomiting

Why should Memantine not be prescribed?

People who have ever had an allergic reaction to Memantine should not take Memantine.

Special warnings about Memantine

Memantine is not recommended for use in patients who have severe kidney impairment.

Certain conditions can alter the alkaline balance of the urine, which may cause a buildup of Memantine in the body. Be sure to tell the doctor about any major dietary changes, kidney problems such as renal acidosis, or urinary tract infections.

Make sure the doctor knows about any history of seizures. Memantine has not been formally studied in people with seizure disorders.

Possible food and drug interactions when taking Memantine

If Memantine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with the doctor before combining Memantine with the following:

Amantadine (Symmetrel)
Cimetadine (Tagamet, Tagamet HB)
Cough suppressants that contain dextromethorphan (usually denoted as "DM")
Glaucoma drugs such as Diamox and Neptazane
Hydrochlorothiazide (HydroDIURIL)
Ketamine (Ketalar)
Nicotine (Nicoderm patch, Nicorette gum)
Quinidine (Quinidex)
Ranitidine (Zantac)
Sodium bicarbonate (baking soda, Alka-Seltzer)
Triamterene (Dyrenium)

Special information if you are pregnant or breastfeeding

Memantine is not usually prescribed for women of childbearing age. There are no adequate and well-controlled studies in pregnant women. It should be used in pregnant women only if the potential benefit to the mother outweighs the risk to the fetus.

It is not known whether Memantine appears in human breast milk. If Memantine is essential to your health, the doctor may advise you to stop nursing until your treatment is finished.

Recommended dosage

ADULTS

The recommended dosage is 10 milligrams twice a day. The doctor will start treatment at 5 milligrams once a day for 7 days, and gradually increase the dose by 5 milligrams every 7 days, up to a maximum total daily dose of 20 milligrams.

If Memantine causes side effects, the doctor may wait more than 1 week to increase the dose. People who have impaired kidney function may require lower doses.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately.

  • Symptoms of overdose may include:
    Loss of consciousness, hallucinations, psychosis, restlessness, sleepiness, stupor




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