Lovastatin 24-Hour Sustained-Release Tablets

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Lovastatin 24-Hour Sustained-Release Tablets


Generic Name: Lovastatin 24-Hour Sustained-Release Tablets (LOW-vuh-STAT-in)
Brand Name: Altoprev

Lovastatin 24-Hour Sustained-Release Tablets is used for:

Lowering cholesterol and triglyceride levels in the blood and for reducing the risk of heart attack, blood vessel blockage, or chest pain in certain patients. It is also used in patients 10 to 17 years of age who have a genetic cholesterol problem. Lovastatin 24-Hour Sustained-Release Tablets is used in combination with a low-cholesterol and low-fat diet. It may also be used for other conditions as determined by your doctor.

Lovastatin 24-Hour Sustained-Release Tablets is a HMG-CoA reductase inhibitor (also known as a "statin"). It works by reducing the production of triglycerides and LDL ("bad") cholesterol in the liver, which helps to lower their blood levels. It also increases the blood levels of HDL ("good") cholesterol.

Do NOT use Lovastatin 24-Hour Sustained-Release Tablets if:

  • you are allergic to any ingredient in Lovastatin 24-Hour Sustained-Release Tablets
  • you are pregnant or are breast-feeding
  • you have active liver disease or abnormal liver function tests (persistent high levels of serum transaminases)
  • you are taking an azole antifungal (eg, itraconazole, ketoconazole), gemfibrozil, an HIV protease inhibitor (eg, ritonavir), a ketolide antibiotic (eg, telithromycin), a macrolide antibiotic (eg, clarithromycin, erythromycin), or nefazodone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lovastatin 24-Hour Sustained-Release Tablets:

Some medical conditions may interact with Lovastatin 24-Hour Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of diabetes, low blood pressure, severe muscle weakness, liver or kidney problems, severe electrolyte problems, severe endocrine or metabolic disease, severe infection, trauma, or uncontrolled seizures
  • if you are scheduled to have major surgery (eg, organ transplantation)
  • if you consume more than 3 alcohol-containing drinks a day or have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Lovastatin 24-Hour Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine, spironolactone, or streptogramins (eg, dalfopristin) because the side effects of Lovastatin 24-Hour Sustained-Release Tablets may be increased
  • Amiodarone, azole antifungals (eg, itraconazole, ketoconazole), cyclosporin, danazol, diltiazem, fibric acid derivatives (eg, clofibrate), gemfibrozil, HIV protease inhibitors (eg, ritonavir), imatinib, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil, nefazodone, niacin, verapamil, or voriconazole because the risk of severe muscle problems, severe kidney problems (eg, rhabdomyolysis), and kidney failure may be increased
  • Bosentan, carbamazepine, rifampin, or St. John"s wort because the effectiveness of Lovastatin 24-Hour Sustained-Release Tablets may be decreased
  • Anticoagulants (eg, warfarin) because side effects may be increased by Lovastatin 24-Hour Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lovastatin 24-Hour Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lovastatin 24-Hour Sustained-Release Tablets:

Use Lovastatin 24-Hour Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Lovastatin 24-Hour Sustained-Release Tablets may be taken with or without food. Take Lovastatin 24-Hour Sustained-Release Tablets at bedtime unless otherwise instructed by your doctor.
  • Swallow Lovastatin 24-Hour Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing.
  • Eating grapefruit or drinking grapefruit juice may affect the amount of Lovastatin 24-Hour Sustained-Release Tablets in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
  • If you miss a dose of Lovastatin 24-Hour Sustained-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lovastatin 24-Hour Sustained-Release Tablets.

Important safety information:

  • Lovastatin 24-Hour Sustained-Release Tablets may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Lovastatin 24-Hour Sustained-Release Tablets. Using Lovastatin 24-Hour Sustained-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Lovastatin 24-Hour Sustained-Release Tablets may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor if you should take Lovastatin 24-Hour Sustained-Release Tablets or other pain relievers/fever reducers. Alcohol use combined with Lovastatin 24-Hour Sustained-Release Tablets may increase your risk for liver damage.
  • Lovastatin 24-Hour Sustained-Release Tablets may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Lovastatin 24-Hour Sustained-Release Tablets. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Lovastatin 24-Hour Sustained-Release Tablets.
  • For best results, Lovastatin 24-Hour Sustained-Release Tablets should be used along with exercise, a low-cholesterol/low-fat diet, and a weight loss program if you are overweight. Follow the dietary plan provided by your doctor.
  • LAB TESTS, including liver function and blood cholesterol tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Lovastatin 24-Hour Sustained-Release Tablets is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Lovastatin 24-Hour Sustained-Release Tablets if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is recommended that women of childbearing age use effective birth control measures while taking Lovastatin 24-Hour Sustained-Release Tablets since lovastatin may cause fetal harm. It is unknown if Lovastatin 24-Hour Sustained-Release Tablets is excreted in breast milk. Do not breast-feed while taking Lovastatin 24-Hour Sustained-Release Tablets.

Possible side effects of Lovastatin 24-Hour Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; dizziness; fever; muscle pain, tenderness, or weakness; severe or persistent vomiting; sore throat; swelling; trouble urinating; unusual bleeding or bruising; unusual tiredness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Lovastatin 24-Hour Sustained-Release Tablets:

Store Lovastatin 24-Hour Sustained-Release Tablets in the refrigerator, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lovastatin 24-Hour Sustained-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Lovastatin 24-Hour Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • This medicine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lovastatin 24-Hour Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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