 |
drug-information.ru |
|Lidex Gel Lidex Ointment |
| Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home LidexGeneric Name: fluocinonide Dosage Form: Gel Rx Only Lidex DescriptionLidex® (fluocinonide) Gel 0.05% is intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide and has the chemical name pregna - 1,4 - diene - 3,20 - dione,21 - (acetyloxy) - 6,9 - difluoro - 11 - hydroxy - 16,17 - [(1 - methylethylidene)bis(oxy)] - ,(6α,11β,16α) - . It has the following chemical structure:  Lidex Gel contains fluocinonide 0.5 mg/g in a specially formulated gel base consisting of carbomer 940, edetate disodium, popyl gallate, propylene glycol, sodium hydroxide and/or hydrochloric acid (to adjust the pH), and water (purified). This clear, colorless, thixotropic vehicle is greaseless, non-staining and completely water miscible. In this formulation, the active ingredient is totally in solution. Lidex - Clinical PharmacologyTopical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. PharmacokineticsThe extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION). Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Indications and Usage for LidexLidex Gel is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. ContraindicationsTopical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. PrecautionsGeneralSystemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing"s syndrome, hyperglycemia, and glucosuria in some patients. Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (see PRECAUTIONS—Pediatric Use). If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. As with any topical corticosteroid product, prolonged use may produce atrophy of the skin and subcutaneous tissues. When used on intertriginous or flexor areas, or on the face, this may occur even with short-term use. In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled. Information for the PatientPatients using topical corticosteroids should receive the following information and instructions:
Laboratory TestsThe following tests may be helpful in evaluating the HPA axis suppression: Urinary free cortisol test ACTH stimulation test Carcinogenesis, Mutagenesis, and Impairment of FertilityLong-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids. Studies to determine mutagenicity with prednisolone and hydrocortisone have revealed negative results. Pregnancy Category CCorticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time. Nursing MothersIt is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman. Pediatric UsePediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing"s syndrome than mature patients because of a larger skin surface area to body weight ratio. Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing"s syndrome, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema. Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children. Adverse ReactionsThe following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
OverdosageTopically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS). Lidex Dosage and AdministrationLidex Gel is generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. Occlusive dressing may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted. How is Lidex SuppliedLidex® (fluocinonide) Gel 0.05% is supplied in 15 g Tube - NDC 99207-507-13 30 g Tube - NDC 99207-507-14 60 g Tube - NDC 99207-507-17 Store at room temperature 15°–30°C (59°–86°F). Manufactured for: MEDICIS, The Dermatology Company® Scottsdale, AZ 85258 April 2001 IN-5071/S
Revised: 07/2006 Where can I get more information about Lidex Gel Lidex Ointment ? We recommend to use www.Drugs.com Typical mistypes for Lidex Gel Lidex Ointment kidex gel lidex ointment, pidex gel lidex ointment, oidex gel lidex ointment, ludex gel lidex ointment, ljdex gel lidex ointment, lkdex gel lidex ointment, lodex gel lidex ointment, l9dex gel lidex ointment, l8dex gel lidex ointment, lisex gel lidex ointment, lixex gel lidex ointment, licex gel lidex ointment, lifex gel lidex ointment, lirex gel lidex ointment, lieex gel lidex ointment, lidwx gel lidex ointment, lidsx gel lidex ointment, liddx gel lidex ointment, lidrx gel lidex ointment, lid4x gel lidex ointment, lid3x gel lidex ointment, lidez gel lidex ointment, lidec gel lidex ointment, lided gel lidex ointment, lides gel lidex ointment, lidex fel lidex ointment, lidex vel lidex ointment, lidex bel lidex ointment, lidex hel lidex ointment, lidex yel lidex ointment, lidex tel lidex ointment, lidex gwl lidex ointment, lidex gsl lidex ointment, lidex gdl lidex ointment, lidex grl lidex ointment, lidex g4l lidex ointment, lidex g3l lidex ointment, lidex gek lidex ointment, lidex gep lidex ointment, lidex geo lidex ointment, lidex gel kidex ointment, lidex gel pidex ointment, lidex gel oidex ointment, lidex gel ludex ointment, lidex gel ljdex ointment, lidex gel lkdex ointment, lidex gel lodex ointment, lidex gel l9dex ointment, lidex gel l8dex ointment, lidex gel lisex ointment, lidex gel lixex ointment, lidex gel licex ointment, lidex gel lifex ointment, lidex gel lirex ointment, lidex gel lieex ointment, lidex gel lidwx ointment, lidex gel lidsx ointment, lidex gel liddx ointment, lidex gel lidrx ointment, lidex gel lid4x ointment, lidex gel lid3x ointment, lidex gel lidez ointment, lidex gel lidec ointment, lidex gel lided ointment, lidex gel lides ointment, lidex gel lidex iintment, lidex gel lidex kintment, lidex gel lidex lintment, lidex gel lidex pintment, lidex gel lidex 0intment, lidex gel lidex 9intment, lidex gel lidex ountment, lidex gel lidex ojntment, lidex gel lidex okntment, lidex gel lidex oontment, lidex gel lidex o9ntment, lidex gel lidex o8ntment, lidex gel lidex oibtment, lidex gel lidex oimtment, lidex gel lidex oijtment, lidex gel lidex oihtment, lidex gel lidex oinrment, lidex gel lidex oinfment, lidex gel lidex oingment, lidex gel lidex oinyment, lidex gel lidex oin6ment, lidex gel lidex oin5ment, lidex gel lidex ointnent, lidex gel lidex ointkent, lidex gel lidex ointjent, lidex gel lidex ointmwnt, lidex gel lidex ointmsnt, lidex gel lidex ointmdnt, lidex gel lidex ointmrnt, lidex gel lidex ointm4nt, lidex gel lidex ointm3nt, lidex gel lidex ointmebt, lidex gel lidex ointmemt, lidex gel lidex ointmejt, lidex gel lidex ointmeht, lidex gel lidex ointmenr, lidex gel lidex ointmenf, lidex gel lidex ointmeng, lidex gel lidex ointmeny, lidex gel lidex ointmen6, lidex gel lidex ointmen5, idex gel lidex ointment, ldex gel lidex ointment, liex gel lidex ointment, lidx gel lidex ointment, lide gel lidex ointment, lidexgel lidex ointment, lidex el lidex ointment, lidex gl lidex ointment, lidex ge lidex ointment, lidex gel lidex ointment, lidex gel lidex ointment, lidex gel idex ointment, lidex gel ldex ointment, lidex gel liex ointment, lidex gel lidx ointment, lidex gel lide ointment, lidex gel lidexointment, lidex gel lidex intment, lidex gel lidex ontment, lidex gel lidex oitment, lidex gel lidex oinment, lidex gel lidex ointent, lidex gel lidex ointmnt, lidex gel lidex ointmet, lidex gel lidex ointmen, ildex gel lidex ointment, ldiex gel lidex ointment, liedx gel lidex ointment, lidxe gel lidex ointment, lide xgel lidex ointment, lidexg el lidex ointment, lidex egl lidex ointment, lidex gle lidex ointment, lidex ge l lidex ointment, lidex gel lidex ointment, lidex gel l idex ointment, lidex gel ildex ointment, lidex gel ldiex ointment, lidex gel liedx ointment, lidex gel lidxe ointment, lidex gel lide xointment, lidex gel lidexo intment, lidex gel lidex iontment, lidex gel lidex onitment, lidex gel lidex oitnment, lidex gel lidex oinmtent, lidex gel lidex ointemnt, lidex gel lidex ointmnet, lidex gel lidex ointmetn, llidex gel lidex ointment, liidex gel lidex ointment, liddex gel lidex ointment, lideex gel lidex ointment, lidexx gel lidex ointment, lidex gel lidex ointment, lidex ggel lidex ointment, lidex geel lidex ointment, lidex gell lidex ointment, lidex gel lidex ointment, lidex gel lidex ointment, lidex gel llidex ointment, lidex gel liidex ointment, lidex gel liddex ointment, lidex gel lideex ointment, lidex gel lidexx ointment, lidex gel lidex ointment, lidex gel lidex oointment, lidex gel lidex oiintment, lidex gel lidex oinntment, lidex gel lidex ointtment, lidex gel lidex ointmment, lidex gel lidex ointmeent, lidex gel lidex ointmennt, lidex gel lidex ointmentt, etc.
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||