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Some commonly used brand names are:
In the U.S.—
Fosamprenavir (fos-am-PREN-a-veer) is a protease inhibitor. It is used in combination with other medicines to treat patients who are infected with the human immunodeficiency virus (HIV).
HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Fosamprenavir may slow down the destruction of the immune system caused by HIV. This may help delay the development of problems usually related to AIDS or HIV disease. However, this medicine will not cure or prevent HIV infection, and it will not keep you from spreading the virus to other people. Patients who are taking this medicine may continue to have the problems usually related to AIDS or HIV disease.
This medicine is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fosamprenavir, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to fosamprenavir, amprenavir (e.g., Agenerase) or sulfa medicines. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Amprenavir has not been studied in pregnant women. However, studies in animals have shown that fosamprenavir causes birth defects and other problems. Fosamprenavir should only be used during pregnancy if the benefit outweighs the potential risk. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether fosamprenavir passes into breast milk. However, breast-feeding is not recommended in patients with HIV infection because of the risk of passing the HIV virus on to the nursing infant. Mothers should not breast-feed while taking amprenavir.
Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of fosamprenavir in children with use in other age groups.
Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is not specific information comparing use of fosamprenavir in the elderly with use in other age groups.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking fosamprenavir, it is especially important that your doctor and pharmacist know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of fosamprenavir. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
Fosamprenavir suspension should be taken without food on an empty stomach.
Fosamprenavir tablets may be taken with or without food. However, it should not be taken with a high-fat meal. Taking fosamprenavir with a high-fat meal may decrease the amount of fosamprenavir that is absorbed by the body and prevent the medicine from working properly.
It is important to take fosamprenavir as part of a combination treatment. Your dose of medicine will be based on what other medicines you are taking, as well as your weight. Be sure to take all the medicines your doctor has prescribed for you, including fosamprenavir.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.
Keep taking fosamprenavir for the full time of treatment, even if you begin to feel better.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If you need help in planning the best times to take your medicine, check with your health care professional.
Only take medicine that your doctor has prescribed especially for you. Do not share your medicine with others.
Dosing—The dose of fosamprenavir will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of fosamprenavir. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage—To store this medicine:
Precautions While Using This Medicine
Do not take any other medicines without checking with your doctor first. This includes prescription and nonprescription medicines. This also includes food supplements, herbs and vitamins. To do so may increase the chance of side effects from fosamprenavir or other medicines.
This medicine may decrease the effects of some oral contraceptives (birth control pills). To avoid unwanted pregnancy, it is a good idea to use some additional contraceptive measures while being treated with fosamprenavir.
For patients with diabetes: Amprenavir may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects, especially increases in blood sugar.
Fosamprenavir does not decrease the risk of transmitting the HIV infection to others through sexual contact or by contamination through blood. HIV may be acquired from or spread to others through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom (“rubber”). Only use condoms made of latex, and use them every time you have vaginal, anal, or oral sex . The use of a spermicide (such as nonoxynol-9) may also help prevent the spread of HIV if it is not irritating to the vagina, rectum, or mouth. Spermicides have been shown to kill HIV in lab tests. Do not use oil-based jelly, cold cream, baby oil, or shortening as a lubricant—these products can cause the condom to break. Lubricants without oil, such as K-Y Jelly , are recommended. Women may wish to carry their own condoms. Birth control pills and diaphragms will help protect against pregnancy, but they will not prevent someone from giving or getting the AIDS virus. If you inject drugs, get help to stop. Do not share needles or equipment with anyone. In some cities, more than half of the drug users are infected, and sharing even 1 needle or syringe can spread the virus. If you have any questions about this, check with your health care professional.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Large amount of triglyceride in the blood; severe skin rash
Abdominal pain; blurred vision; depression mood or mental changes; dry mouth; fatigue; flushed, dry skin; fruit-like breath odor; increased hunger; increased thirst; increased urination; nausea; sweating; troubled breathing; unexplained weight loss; vomiting
Back, leg, or stomach pains; bleeding gums; blistering, peeling, loosening of skin; chills; cough; dark urine; diarrhea; difficulty breathing; fever; general body swelling; itching; joint or muscle pain; loss of appetite; nosebleeds; pale skin; red irritated eyes; red skin lesions often with a purple center; sore throat; sores, ulcers, or white spots in mouth or on lips; unusual tiredness or weakness; yellowing of the eyes or skin
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
Itching skin; mild or moderate rash
Burning or prickling sensation around the mouth; headache
Frequency not known
Breast enlargement; obesity; increased fat deposits on face, neck, and truck; buffalo hump; fat redistribution
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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