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|Isoniazid/Pyrazinamide/Rifampin

Isoniazid/Pyrazinamide/Rifampin

Isoniazid/Pyrazinamide/Rifampin is used for:

Treating tuberculosis of the lungs.

Isoniazid/Pyrazinamide/Rifampin is a combination of 3 antibacterial agents. It works by stopping the growth of and killing sensitive bacteria.

Do NOT use Isoniazid/Pyrazinamide/Rifampin if:

• you are allergic to any ingredient in Isoniazid/Pyrazinamide/Rifampin
• you have severe liver damage or active liver disease
• you have active gout
• you have had severe side effects from isoniazid, such as drug fever, chills, or arthritis
• you are taking voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Isoniazid/Pyrazinamide/Rifampin :

Some medical conditions may interact with Isoniazid/Pyrazinamide/Rifampin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diabetes, the blood disease porphyria, liver or kidney problems, abnormal liver function tests, or a history of gout or inflammation of the colon due to antibiotic use (eg, pseudomembranous colitis)
• if you have alcoholism or drink alcohol daily

Some MEDICINES MAY INTERACT with Isoniazid/Pyrazinamide/Rifampin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many prescription and nonprescription medicines (eg, used for alcoholism, allergic reactions, anxiety, arthritis, asthma, birth control, blood pressure, blood thinning, cancer, cholesterol, depression, diabetes, Hansen disease, heart problems, HIV, hormone replacement, immune system suppression, infections, irregular heartbeat, mental or mood problems, nausea and vomiting, pain, seizures, sleep) may interact with Isoniazid/Pyrazinamide/Rifampin by increasing the risk for side effects or decreasing effectiveness
• Voriconazole because it may increase the risk of Isoniazid/Pyrazinamide/Rifampin "s side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Isoniazid/Pyrazinamide/Rifampin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Isoniazid/Pyrazinamide/Rifampin :

Use Isoniazid/Pyrazinamide/Rifampin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Isoniazid/Pyrazinamide/Rifampin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
• Do not take an antacid within 1 hour before or 2 hours after you take Isoniazid/Pyrazinamide/Rifampin .
• If you also take aminosalicyclic acid granules do not take it with in 8 to 12 hours of Isoniazid/Pyrazinamide/Rifampin . Check with your doctor if you have questions.
• Continue to use Isoniazid/Pyrazinamide/Rifampin even if you feel well. Do not miss any doses.
• If you miss a dose of Isoniazid/Pyrazinamide/Rifampin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Isoniazid/Pyrazinamide/Rifampin .

Important safety information:

• Isoniazid/Pyrazinamide/Rifampin may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Isoniazid/Pyrazinamide/Rifampin . Using Isoniazid/Pyrazinamide/Rifampin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Check with your doctor before drinking alcohol while taking Isoniazid/Pyrazinamide/Rifampin . Alcohol may increase the risk of liver problems.
• Take Isoniazid/Pyrazinamide/Rifampin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
• Do not take an antacid within 1 hour before or 2 hours after you take Isoniazid/Pyrazinamide/Rifampin .
• If you also take aminosalicyclic acid granules do not take it with in 8 to 12 hours of Isoniazid/Pyrazinamide/Rifampin . Check with your doctor if you have questions.

Possible side effects of Isoniazid/Pyrazinamide/Rifampin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; gas; headache; heartburn; stomach upset or cramps; trouble sleeping.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; changes in vision; chest pain; chills or fever; confusion; dark urine; decreased urination; general feeling of discomfort; increased thirst or urination; irregular heartbeat; joint pain or swelling; loss of appetite; memory problems; menstrual changes; mental or mood changes; nausea; ringing in the ears; seizures; severe diarrhea; shortness of breath; speech problems; stomach pain; swelling of the legs; tightness in the chest; tingling or numbness in the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; weakness on one side of the body; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; hallucinations; loss of consciousness; seizures; severe dizziness; sluggishness; slurred speech; stomach pain; unusually slow breathing; vomiting.

Store Isoniazid/Pyrazinamide/Rifampin between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Isoniazid/Pyrazinamide/Rifampin out of the reach of children and away from pets.

General information:

• If you have any questions about Isoniazid/Pyrazinamide/Rifampin , please talk with your doctor, pharmacist, or other health care provider.
• Isoniazid/Pyrazinamide/Rifampin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Isoniazid/Pyrazinamide/Rifampin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.