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Marplan, |isocarboxazid Isocarboxazid

isocarboxazid

Generic Name: isocarboxazid (eye so kar BOX a zid)
Brand Names: Marplan

What is isocarboxazid?

Isocarboxazid is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain.

Isocarboxazid is used to treat symptoms of depression that may include anxiety, panic, or phobias. This medication is usually given after other antidepressants have been tried without successful treatment of symptoms.

Isocarboxazid may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about isocarboxazid?

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with isocarboxazid. Do not take isocarboxazid before telling your doctor about all other prescription and over-the-counter medications you use, including vitamins, minerals, and herbal products. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking this medication you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

You should become very familiar with the list of foods and medicines you must avoid while you are taking isocarboxazid.

What should I discuss with my doctor before taking isocarboxazid?

• pheochromocytoma (tumor of the adrenal gland);

• a history of stroke or blood clots;

• liver disease;

• kidney disease;

• heart disease;

• high blood pressure; or

• a history of severe or frequent headaches.

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with isocarboxazid. The following drugs should not be used while you are taking isocarboxazid:

• diet pills, caffeine, stimulants, ADHD medication, asthma medication, over-the-counter cough and cold or allergy medicines;

• blood pressure medication;

• diuretics (water pills);

• bupropion (Wellbutrin, Zyban);

• buspirone (BuSpar); or

• carbamazepine (Carbatrol, Tegretol);

• furazolidone (Furoxone);

• meperidine (Demerol, Mepergan);

• pargyline (Eutonyl);

• procarbazine (Matulane);

• alcohol or medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety).

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adepin, Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil); or

• antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

Before taking isocarboxazid, tell your doctor if you have:

• high blood pressure, heart disease;

• diabetes;

• liver or kidney disease;

• a thyroid disorder;

• schizophrenia;

• epilepsy or other seizure disorder;

• if you have taken another antidepressant within the past 5 weeks; or

• if you are also taking tryptophan (also called L-tryptophan), guanethidine (Ismelin), levodopa (Larodopa, Parcopa, Sinemet), or methyldopa (Aldomet).

If you have any of these conditions, you may not be able to use isocarboxazid, or you may need a dosage adjustment or special tests during treatment.

You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking isocarboxazid you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. In addition to you watching for changes in your own symptoms, your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

How should I take isocarboxazid?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure this medication is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while taking isocarboxazid?

• cheese (especially strong or aged cheeses);

• sour cream;

• beer (including non-alcoholic beer), sherry, Chianti wine, liquers;

• dry sausage (such as hard salami, pepperoni, anchovies, caviar, liver, pickled herring;

• canned figs, raisins, bananas;

• avocados;

• chocolate or caffeine;

• soy sauce;

• sauerkraut;

• fava beans;

• yeast extracts;

• yogurt;

• meat extracts;

• meat prepared with tenderizer; or

• over-the-counter supplements or cough and cold medicines that contain dextromethorphan or tyramine.

You should become very familiar with the list of foods and medicines you must avoid while you are taking isocarboxazid. Eating tyramine while you are taking isocarboxazid can raise your blood pressure to dangerous levels which could cause life-threatening side effects.

Isocarboxazid side effects

• sudden and severe headache, rapid heartbeat, stiffness in your neck, nausea, vomiting, cold sweat, sweating, vision problems, sensitivity to light;

• chest pain, fast or slow heart rate;

• swelling, rapid weight gain;

• jaundice (yellowing of the skin or eyes);

• agitation, unusual thoughts or behavior; or

• feeling light-headed, fainting.

Continue taking this medication and talk to your doctor if you have any of these less serious side effects:

• dizziness, headache;

• tremors or shaking;

• sleep problems (insomnia);

• constipation,nausea; or

• dry mouth.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect isocarboxazid?

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with isocarboxazid. Do not take isocarboxazid before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

Where can I get more information?

• Your pharmacist has more information about isocarboxazid written for health professionals that you may read.

What does my medication look like?

Isocarboxazid is available with a prescription under the brand name Marplan. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Marplan 10 mg--peach colored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.