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|Indinavir

Indinavir

Indinavir is used for:

Treating HIV along with other medicines. Indinavir is not a cure for HIV.

Indinavir is an HIV protease inhibitor. It works by slowing the growth of HIV in the body.

Do NOT use Indinavir if:

• you are allergic to any ingredient in Indinavir
• you are taking alfuzosin, amiodarone, astemizole, atazanavir, certain benzodiazepines (eg, midazolam, triazolam), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, an ergot derivative (eg, ergonovine, ergotamine), erythromycin, pimozide, a proton pump inhibitor (eg, omeprazole), rifampin, a serotonin 5-HT₁ receptor antagonist (eg, eletriptan, sumatriptan), St. John"s wort, or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Indinavir :

Some medical conditions may interact with Indinavir . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver or kidney problems, diabetes, high blood sugar, high cholesterol, kidney stones, urinary problems (eg, white blood cells in the urine), or blood problems (eg, hemophilia)

Some MEDICINES MAY INTERACT with Indinavir . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturates (eg, phenobarbital), carbamazepine, didanosine, efavirenz, hydantoins (eg, phenytoin), nevirapine, proton pump inhibitors (eg, omeprazole), rifabutin, rifampin, or St. John"s wort because they may decrease the effectiveness of Indinavir
• Delavirdine, imidazole antifungals (eg, ketoconazole), or nelfinavir because the risk of side effects of Indinavir may be increased
• Antiarrhythmics (eg, amiodarone, bepridil, lidocaine, quinidine), astemizole, cisapride, macrolide antibiotics (eg, clarithromycin, erythromycin), pimozide, or terfenadine because side effects such as heart problems may be increased
• Aldosterone blockers (eg, spironolactone), atazanavir, certain benzodiazepines (eg, alprazolam, midazolam, triazolam), calcium channel blockers (eg, nifedipine), certain HMG-CoA reductase inhibitors (eg, atorvastatin, lovastatin, simvastatin), cyclosporine, ergot derivatives (eg, ergonovine, ergotamine), erlotinib, fluoxetine, macrolide immunosuppressants (eg, tacrolimus), muscarinic receptor antagonists (eg, darifenacin), narcotic analgesics (eg, fentanyl), phosphodiesterase type 5 inhibitors (eg, sildenafil), quinazolines (eg, alfuzosin), rifampin, saquinavir, serotonin 5-HTsub 1 receptor antagonists (eg, eletriptan, sumatriptan), or trazodone because the actions and side effects of these medicines may be increased
• Hormonal contraceptives (eg, birth control pills) or methadone because their effectiveness may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Indinavir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Indinavir :

Use Indinavir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Indinavir at least 1 hour before or 2 hours after eating.
• Indinavir comes with an additional patient leaflet. Read it carefully. Ask your doctor or pharmacist any questions that you may have about this medicine.
• Take Indinavir with water. Indinavir may be taken with other liquids such as skim milk, juice, coffee, or tea, or a light meal that is low in calories, fat, and protein.
• Drinking extra fluids while you are taking Indinavir is recommended. You should drink at least 48 ounces (1.5 L) of water a day unless otherwise directed by your doctor.
• Take Indinavir at least 1 hour before didanosine.
• Large amounts of garlic may decrease the effectiveness of Indinavir . Talk with your doctor before including garlic in your diet.
• Eating grapefruit or drinking grapefruit juice while you are taking Indinavir may increase the amount of Indinavir in your blood, which may increase your risk for serious side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
• Take Indinavir on a regular schedule every 8 hours around the clock, unless otherwise directed by your doctor.
• Take Indinavir regularly to receive the most benefit from it. Taking Indinavir at the same time each day will help you remember to take it.
• Continue to take Indinavir even if you feel well. Do not miss any doses.
• If you miss a dose of Indinavir by more than 2 hours, do not take that dose. Take your next dose as scheduled. If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of Indinavir . Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Indinavir .

Important safety information:

• Indinavir may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Indinavir . Using this medicine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Indinavir is not a cure for HIV infection and patients may continue to acquire illnesses and infections associated with HIV. Remain under the care of your doctor.
• When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. The virus may develop resistance to Indinavir and become more difficult to treat if you stop taking it, even for a short period of time.
• Indinavir offers no protection from the transmission of HIV to others through sexual contact or blood contamination. Use barrier forms of contraception (eg, condoms) if you are infected with HIV.
• Indinavir may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.
• Changes in body fat may occur while you are taking Indinavir (eg, increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss any new questions or concerns with your doctor.
• Indinavir may decrease the effectiveness of hormonal contraceptives (eg, birth control pills). To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Indinavir .
• Diabetes patients - Indinavir may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• LAB TESTS, including liver function tests, cholesterol tests, blood counts, and CD4 counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Indinavir with extreme caution in CHILDREN younger than 3 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Indinavir if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. HIV-infected mothers should not breastfeed their infants because of the risk of transmitting the HIV infection or Indinavir . It is unknown if Indinavir is excreted in breast milk. Do not breast-feed while taking Indinavir .

Possible side effects of Indinavir :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; nausea; tiredness; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back, flank, or side pain; bloody or cloudy urine; change in the amount of urine; changes in appetite; chest pain; chills; confusion; dark urine; fast or irregular heartbeat; fever; flushed face; heartburn; ingrown toenails; joint or muscle aches; mental or mood changes; numbness of the mouth; one-sided weakness; pain while urinating; pale stools; severe dizziness or fainting; speech problems; stomach pain or upset; swelling of the feet, hands, lower legs, or stomach; unusual hair loss; unusual paleness; unusual tiredness; unusually dry skin; vision changes; weight changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blood in urine; diarrhea; lower back pain; nausea; vomiting.

Store Indinavir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Leave the dessicant in the bottle. Do not eat the dessicant. Keep Indinavir out of the reach of children and away from pets.

General information:

• If you have any questions about Indinavir , please talk with your doctor, pharmacist, or other health care provider.
• Indinavir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Indinavir . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.