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|Hyaluronidase

HYALURONIDASE (Parenteral-Local)†

Some commonly used brand names are:

In the U.S.—

• Amphadase
• Vitrase

† Not commercially available in Canada.

Category

• Enzyme (promotes diffusion of injected substances)

Description

Hyaluronidase (hye-al-ur-ON-i-dase) is a natural substance found in the body. Hyaluronidase is collected from either cows or pigs. It is cleaned up to remove animal substances. Hyaluronidase is a spreading substance. Hyaluronidase is used with other drugs given under the skin to improve their uptake by the body. This method of drug delivery is only used when the drug cannot be given by injection into a vein.

This medicine is available only with your doctor"s prescription, in the following dosage forms:

• Parenteral
• Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hyaluronidase, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to hyaluronidase. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Hyaluronidase has not been studied in pregnant women or animals. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether hyaluronidase passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking hyaluronidase, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Dopamine (e.g., Intropin)—Hyaluronidase should not be used with dopamine.

Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of hyaluronidase. Make sure you tell your doctor if you have any other medical problems.

Proper Use of This Medicine

Dosing—The dose of hyaluronidase will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of hyaluronidase. If your dose is different, do not change it unless your doctor tells you to do so.

• For injection dosage form:
  • For better uptake of other drugs:
    • Adults—Use and dose must be determined by your doctor.
    • Children—Use and dose must be determined by your doctor.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store in the refrigerator. However, keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Some people may be allergic to this medicine. Tell your doctor if you develop red or itching skin or if you have trouble breathing after you receive hyaluronidase.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 02/28/2005

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