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|Hepatitis A Vaccine, Inactivated |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Hepatitis A Vaccine, InactivatedPronouncation: (Hep-ah-TY-tiss)Class: Vaccine, viral Trade Names: Trade Names: Avaxim Pediatric (Canada) Epaxal Berna (Canada) Mechanism of ActionPharmacologyProvides active immunization. Indications and UsageActive immunization of patients 12 mo of age and older against disease caused by hepatitis A virus. ContraindicationsPrevious hypersensitivity to any hepatitis A–containing vaccine; hypersensitivity to any component of the vaccine, including neomycin. Dosage and AdministrationAdults (19 yr of age and older)IM (in the deltoid region) Havrix 1440 EL.U. (1 mL) followed by a booster dose 6 to 12 mo later or Vaqta 50 units (1 mL) followed by a booster dose 6 to 18 mo later. Children (12 mo through 18 yr of age)IM Havrix 720 EL.U. (0.5 mL) followed by a booster dose of 720 EL.U. 6 to 12 mo later or Vaqta 25 units (0.5 mL) followed by a booster dose of 25 units (0.5 mL) 6 to 18 mo later. General Advice
Products are interchangeable for booster dose (eg, Vaqta can be used for booster dose following primary dose of Havrix ). Booster dose should be same strength as primary dose. Storage/StabilityStore vials and syringes in refrigerator (36° to 46°F). Do not freeze. Discard if vaccine has been frozen because freezing destroys potency. Drug InteractionsAnticoagulantsBecause bleeding may occur following IM administration, use with caution. Immune globulin (IG)Compared with giving hepatitis A vaccine alone, when coadministered with IG, lower antibody titers may be obtained. However, hepatitis A vaccine and IG may be given concurrently using different syringes and different injection sites. ImmunosuppressantsMay result in inadequate response to immunization; therefore, additional administration of vaccine may be required. Other vaccinesUse separate injection sites and syringes when injecting concomitant vaccines. Adverse ReactionsCardiovascularHavrixSyncope (postmarketing). CNSHavrixHeadache (14%); fatigue, malaise (1% to 10%); hypertonic episode, insomnia, photophobia, vertigo (greater than 1%); convulsions, dizziness, encephalopathy, Guillain-Barré syndrome, multiple sclerosis, myelitis, neuropathy, paresthesia, somnolence (postmarketing). VaqtaAdults: headache (16%); asthenia/fatigue (4%). Children (12 through 23 mo of age): irritability (11%); crying (2%). Children (2 through 18 yr of age): headache (2%). Postmarketing: cerebellar ataxia; encephalitis; Guillain-Barré syndrome. DermatologicHavrixAngioedema, erythema multiforme, hyperhidrosis (postmarketing). VaqtaChildren (12 through 23 mo of age): rash (4%); measles-like rash, varicella-like rash, viral erythema (1%). EENTVaqtaAdults: pharyngitis (3%); nasal congestion (1%). Children (12 through 23 mo of age): otitis media (8%); rhinorrhea (6%); otitis (2%); conjunctivitis, nasal congestion (1%). Children (2 through 18 yr of age): pharyngitis (2%). GIHavrixAnorexia, nausea (1% to 10%). VaqtaAdults: diarrhea (3%); nausea (2%). Children (12 through 23 mo of age): diarrhea (6%); vomiting (4%); anorexia (1%). Children (2 through 18 yr of age): abdominal pain (2%); diarrhea, vomiting (1%). GenitourinaryVaqtaAdults: menstrual disorder (1%). Hematologic-LymphaticVaqtaAdults: ecchymosis (2%). Children (12 through 23 mo of age): ecchymosis (1%). Postmarketing: thrombocytopenia. HepaticHavrixPostmarketing: hepatitis; jaundice. LocalHavrixPain (22%); induration, redness, swelling (1% to 10%). VaqtaAdults: tenderness (53%); pain (51%); warmth (17%); swelling (14%); erythema (13%); ecchymosis (2%); pain/soreness (1%). Children (12 through 23 mo of age): pain/soreness/tenderness (4%); erythema, swelling (2%); warmth (1%). Children (2 through 18 yr of age): pain (19%); tenderness (17%); warmth (9%); erythema (8%); swelling (7%); ecchymosis (1%). MusculoskeletalVaqtaAdults: myalgia (2%); arm pain, back pain, stiffness (1%). RespiratoryHavrixDyspnea (postmarketing). VaqtaAdults: upper respiratory tract infection (3%). Children (12 through 23 mo of age): upper respiratory tract infection (10%); cough (5%); respiratory congestion (2%); laryngotracheobronchitis (1%). Children (2 through 18 yr of age): cough, upper respiratory infection (1%). MiscellaneousHavrixFever (1% to 10%); anaphylaxis/anaphylactoid reactions, congenital abnormalities (postmarketing). VaqtaAdults: fever (3%); abdominal pain (1%). Children (12 through 23 mo of age): fever (11%). Children (2 through 18 yr of age): fever (3%). PrecautionsPregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established in children younger than 12 mo of age. AnaphylaxisThere have been rare reports of anaphylaxis and anaphylactoid reactions. Bleeding disordersBecause bleeding may occur with IM injections, do not administer to individuals with bleeding disorders, such as hemophilia or thrombocytopenia, or patients on anticoagulant therapy. Febrile illnessMay need to delay administration. HepatitisHepatitis A vaccine will not prevent hepatitis caused by other agents, such as hepatitis B, C, or E virus or other pathogens that infect the liver. ImmunosuppressionThe expected immune response may not be obtained in immunosuppressed patients. Latex allergyProducts may contain dry natural latex rubber. Preexisting infectionHepatitis A vaccine may not prevent hepatitis A infection in individuals who have an unrecognized hepatitis A infection at the time of vaccination; in addition, it may not prevent infection in individuals who do not achieve protective antibody titers. Patient Information
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